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Cited by 166Hearing, Cochlea, Tinnitus, GeneticsNeuroscience and Neuropharmacology ResearchVestibular and auditory disorders

The effect of bilateral deafness on excitatory and inhibitory synaptic strength in the inferior colliculus

Vale, Carmen, Sanes, Dan H.·2002·European Journal of Neuroscience
DOI 10.1046/j.1460-9568.2002.02302.x
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Abstract

The consequences of deafness on the central auditory nervous system have been examined at many levels, from molecular to functional. However, there has never been a direct and selective measurement of excitatory synaptic function following total hearing loss. In the present study, gerbils were deafened at postnatal day 9, an age at which there is no deafferentation-induced cell death of ventral cochlear nucleus neurons. One to five days after bilateral cochlear ablation, the amplitude of evoked excitatory postsynaptic currents (EPSC) was measured with whole-cell voltage-clamp recordings in an inferior colliculus (IC) brain slice preparation in response to electrical stimulation of the ipsilateral lateral lemniscus (LL) or the commissure of the inferior colliculus (CIC). Deafness resulted in larger LL- and CIC-evoked EPSC amplitudes and durations. This result was observed at a depolarized holding potential. In addition, deafness caused a decrease in excitatory neurotransmitter release at the LL pathway, as assessed with a paired-pulse stimulation protocol. In contrast to its effect on excitatory synapses, bilateral cochlear ablation reduced inhibitory synaptic strength in IC neurons. The effects included a postsynaptic decrease in IPSC conductance, a 25-mV depolarization in the IPSC equilibrium potential and a decrease of neurotransmitter release. Thus normal innervation differentially affects excitatory and inhibitory synaptic strength in IC neurons, and these changes may con…

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  • Inhibitory synapses onto pyramidal neurons are regulated in the opposite direction from excitatory synapses in response to a drop in activity or sensory drive, both in vitro and in vivo.

    “Further, it has been shown both in vitro and in vivo that inhibitory synapses onto pyramidal neurons are regulated in the opposite direction from excitatory synapses in response to a drop in activity or sensory drive (Kilman et al. 2002;Vale and Sanes 2002;Maffei et al. 2004;Hartman et al. 2006;Huupponen et al. 2007).”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Vale and Sanes 2002

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Authors
Vale, C., & Sanes, D. H.
Affiliations
New York University (US)
Corresponding author
Sanes, Dan H.
ORCID
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2002-12
Volume
16
Issue
12
Pages
2394-2404
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1046/j.1460-9568.2002.02302.x
OpenAlex
W1996809637
Cited by
166
References
1
Citations by year
2026: 3 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 8 · 2012: 10
FWCI
3.50
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 17 d)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Deafness and Other Communication Disorders (DC-00540)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords
bilateral deafness, inferior colliculus, cochlear ablation, sensory deprivation, excitatory postsynaptic currents, inhibitory postsynaptic currents, neurotransmitter release, lateral lemniscus, auditory brainstem, gerbils
MeSH terms
Animals, Animals, Newborn, Auditory Pathways, Cochlea, Deafness, Electric Stimulation, Gerbillinae, Inferior Colliculi, Functional Laterality, Membrane Potentials, Neural Inhibition, Synaptic Transmission, Neuronal Plasticity, Synapses, Receptors, N-Methyl-D-Aspartate, Excitatory Postsynaptic Potentials

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