Cited by 220Migraine and Headache StudiesTraumatic Brain Injury ResearchTemporomandibular Joint Disorders

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Comorbidity of Headache and Depressive Disorders

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Mitsikostas, DD, Thomas, AM·1999·Cephalalgia

DOI 10.1046/j.1468-2982.1999.019004211.x

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Abstract

The goal of the present study was to investigate the clinical profile of patients with primary headache syndromes who also suffer from mood disorders. Four-hundred-and-seventy headache outpatients (170M, 300F) and 150 age- and sex-matched healthy subjects were screened using a specific questionnaire that included the Hamilton rating scales for anxiety and depression. The average scores of the Hamilton rating scales for anxiety and depression were significantly higher in headache sufferers (17.4 and 14.2, respectively) than in healthy people (6.8 and 5.7, respectively). The frequency of headache attacks, the history of headaches, and gender (women more than men) were correlated with the score of the Hamilton rating scale for both anxiety and depression. Sixteen headache patients (3.4%) achieved the DSM-IV criteria for major depression or dysthymia versus one among headache-free subjects (0.6%; OR 5.2). Patients suffering from drug-overuse and migraine with aura showed the higher odds ratios (35 and 17, respectively). These results suggest that those headache patients with long history and high frequency of headaches, or patients suffering from migraine with aura and drug-overuse might benefit from psychiatric evaluation.

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Fumal, A., de Noordhout, A. M., Schoenen, J. E., O’Reardon, J. P., Fontecha-Hernández, J., & Cristancho, M. A. (2008) · CNS Spectrums · doi:10.1017/s1092852900028418
Céphalées de l’enfant et psychopathologie
Rousseau‐Salvador, C., & Amouroux, R. (2014) · Springer eBooks · doi:10.1007/978-2-8178-0235-0_4
Céphalées de tension
Dousset, V., & Brochet, B. (2005) · Encyclopédie médico-chirurgicale. Neurologie · doi:10.1016/j.emcn.2005.01.005
Tension type headache
Bendtsen, L. (2013) · The Journal of Headache and Pain · doi:10.1186/1129-2377-14-s1-o2
Kopfschmerz zurückzuführen auf psychische Störungen
Göbel, H. (2012) · Springer eBooks · doi:10.1007/978-3-642-20695-5_20
The modulating effect of bruxism as a form of suppressed hostility on depression in a selected population of tension type headache (ttha) and craniomandibular disorders (cmds) individuals. O efeito modulador do bruxismo como uma forma de hostilidade reprimida numa população seleta com dor de cabeça por tensão muscular e distúrbios craniomandibulares (dcms).
Molina, O. F., Peixoto, M. G. S., Aquilino, R. N., & Rank, R. C. I. C. (2017) · Cadernos UniFOA · doi:10.47385/cadunifoa.v6i15.1045
Cefaleias Tipo Tensão ‑ Perspetiva Psiquiátrica Tension ‑Type Headache ‑ Psychiatric Perspective
Mendes, J. C., & Ribeiro, L. (2012)
PRESENTATION, TREATMENT, IMPACT AND OUTCOME
Abbas, M. A., Ismaiel, H., Young, B., & Silberstein, S. D. (2010)
Abstracts and Citations
Landy, S. H., Kaniecki, R. G., & Taylor, F. R. (2011) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2011.01876.x
Trajectories of Headache Disability Treatment Response: Psychosocial and Clinical Correlates
Lewis, K. N. (2009) · OhioLink ETD Center (Ohio Library and Information Network)
Screening Patients With Headaches for Abuse
Schulman, E. A., & Franchek-Roa, K. M. (2015) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000200
Co-Morbidity in an Elderly Inpatient Population: Are the Risks of Co-Existing Conditions Differentially Distributed?
Broyles, R. W., Khaliq, A. A., & Robertson, M. J. (2005) · Journal of Health and Human Services Administration · doi:10.1177/107937390502800301
Epidemiology of the psychiatric comorbidities of headache
Mullin, K., Buse, D. C., Sollars, C. M., & Lipton, R. B. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139206952.002

Authors: Mitsikostas, D., & Thomas, A.
Affiliations: Athens Naval & Veterans Hospital (GR)
Corresponding author: Mitsikostas, DD
Venue: Cephalalgia
Publisher: SAGE Publications
Published: 1999-05
Volume: 19
Issue: 4
Pages: 211-217
ISSN: 0333-1024 (ISSN-L)
1468-2982
DOI: 10.1046/j.1468-2982.1999.019004211.x
OpenAlex: W2124679602
Cited by: 220
References: 37
Citations by year: 2026: 3 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 10 · 2018: 7 · 2017: 4 · 2016: 12 · 2015: 5 · 2014: 11 · 2013: 17 · 2012: 5
FWCI: 4.75
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Cephalalgia (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Health Sciences › Dentistry › Oral Surgery › Temporomandibular Joint Disorders
Keywords: headache, depressive disorders, comorbidities, mood disorders, anxiety, major depressive disorder, dysthymia, migraine with aura, headache frequency, mental health screening, Hamilton Depression Rating Scale
MeSH terms: Adult, Depressive Disorder, Female, Follow-Up Studies, Headache, Humans, Male, Medical Records, Surveys and Questionnaires, Reproducibility of Results, Case-Control Studies

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