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Correcting for multiple analyses in genomewide linkage studies
Abstract
The dissection of complex traits frequently calls for multiple analyses to be performed, including the use of both multiple phenotypes and genetic models. These multiple phenotypes and models are often not independent, and hence the necessary correction for the multiple testing is not straightforward. In this paper we offer a new approach to address the problem of how to correct for non‐independent multiple analyses in genomewide linkage studies. We describe one method of how to determine the number of ‘effectively independent’ tests performed in a linkage study using simple linear regression techniques. Further we describe how to use such information to establish genomewide significance thresholds for infinitely dense genomewide maps.
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“we considered different modes of inheritance and corrected for multiple tests [28].”
From Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience (2017) · cites this paper as [28]
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- Lathrop, G. M., Lalouel, J.-M., Julier, C. & Ott, J. (1984). Strategies for multilocus linkage analysis in humans. Proc. Natl. Acad. Sci. USA. 81, 3443-6.
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Levinson, D. F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.024 · Cited by 855
Initiative, F. T. A. D. N., Ridge, P. G., Karch, C. M., Hsu, S., Arano, I., Teerlink, C. C., Ebbert, M. T. W., Gonzalez Murcia, J. D., Farnham, J. M., Damato, A. R., et al. (2017) · Genome Medicine · doi:10.1186/s13073-017-0486-1 · Cited by 83
Self-citationKunkle, B. W., Jaworski, J., Barral, S., Vardarajan, B., Beecham, G. W., Martin, E. R., Cantwell, L. S., Partch, A., Bird, T. D., Raskind, W. H., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.05.020 · Cited by 32
“9! 10(25)) in LOD score analyses of densemarker genome-wide linkage scans and approximates a level suggested by Camp and Farnham [24] for testing of two independent two-point models.”
Background
Metadata
- Authors
- CAMP, N. J., & FARNHAM, J. M.
- Venue
- Annals of Human Genetics
- Publisher
- Wiley
- Published
- 2001-11
- Volume
- 65
- Issue
- 6
- Pages
- 577-582
- ISSN
- 0003-4800
- 1469-1809
- Cited by
- 50
- References
- 0
- Language
- en
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- CAMP, N. J., & FARNHAM, J. M. (2001). Correcting for multiple analyses in genomewide linkage studies. Annals of Human Genetics. https://doi.org/10.1046/j.1469-1809.2001.6560577.x
