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Free Radical‐Generated Neurotoxicity of 6‐Hydroxydopamine
Abstract
Abstract: Albino rats were lesioned bilaterally with 6‐hydroxydopamine (6‐OHDA) hydrochloride (4 µg/µl, dissolved in saline with 0.1% ascorbic acid) into the striatum, and 72 h after the injection, levels of lipid peroxidation, GSH, superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), lipid class, membrane fluidity, and intracellular calcium concentrations were studied and the results were compared with those in the sham‐operated controls. The malonaldialdehyde level and the level of conjugated dienes were increased by 43 and 40%, respectively, in corpus striatum, and GSH, SOD, and GSH‐Px levels were decreased (24–30%) following 6‐OHDA treatment. Total phospholipid content was also decreased (18%), whereas cholesterol content remained unaffected. Among the different phospholipids only phosphatidylcholine and phosphatidylinositol were decreased in level. Membrane fluidity was decreased (23%), whereas the intracellular calcium concentration was elevated (100%) in corpus striatum compared with control rats. The results suggest that these alterations in membrane‐related events by 6‐OHDA could be due to free radical generation.
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Cited by
Blum, D., Torch, S., Lambeng, N., Nissou, M.-F., Benabid, A.-L., Sadoul, R., & Verna, J.-M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00003-x · Cited by 1,246
Classic toxin-induced animal models of Parkinson?s disease: 6-OHDA and MPTP
Schober, A. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0938-y · Cited by 803
Animal models of Parkinson's disease
Betarbet, R., Sherer, T. B., & Greenamyre, J. T. (2002) · BioEssays · doi:10.1002/bies.10067 · Cited by 592
Gerlach, M., & Riederer, P. (1996) · Journal of Neural Transmission · doi:10.1007/bf01291788 · Cited by 498
Lu, Z., Nie, G., Belton, P. S., Tang, H., & Zhao, B. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.10.010 · Cited by 485
Metadata
- Authors
- Kumar, R., Agarwal, A. K., & Seth, P. K.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1995-04
- Volume
- 64
- Issue
- 4
- Pages
- 1703-1707
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1972108431
- Cited by
- 202
- References
- 0
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kumar, R., Agarwal, A. K., & Seth, P. K. (1995). Free Radical‐Generated Neurotoxicity of 6‐Hydroxydopamine. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.1995.64041703.x
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