Cited by 218Alcohol Consumption and Health EffectsAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

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Ethanol Increases Cytochrome P4502E1 and Induces Oxidative Stress in Astrocytes

Montoliu, C., Sancho‐Tello, M., Azorin, I., Burgal, M., Vallés, S., Renau‐Piqueras, J., Guerri, C.·1995·Journal of Neurochemistry

DOI 10.1046/j.1471-4159.1995.65062561.x

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Abstract

Abstract: We demonstrate the presence of cytochrome P4502E1 (CYP2E1) in astrocytes in primary culture, its induction by ethanol, and the concomitant generation of free radical species. Double immunofluorescence using anti‐CYP2E1 and anti‐glial fibrillary acidic protein showed that CYP2E1 was distributed over the cytoplasm and processes, although labeling was more pronounced over the nuclear membrane. Immunogold labeling confirmed this pattern of distribution. Addition of 25 m M ethanol to the astrocyte culture medium for 14 days resulted in an increase in the CYP2E1 content, as determined by confocal microscopy and dot blot. In addition, ethanol induced a dose‐dependent increase in the formation of reactive oxygen species that was partially prevented by incubating the astrocytes with anti‐CYP2E1. Alcohol also induced a dose‐dependent increase in malonaldehyde and hydroxynonenal formation and a depletion of the glutathione (GSH) content. These results suggest that ethanol induces oxidative damage in astrocytes, which could explain some of the toxic effects of ethanol on these cells, such as cytoskeletal alterations. This assumption is supported here by the fact that an increase in GSH content prevents the deleterious effects of alcohol on the cytoskeleton of astrocytes. These results suggest that importance of oxidative stress as a mechanism involved in alcohol‐induced neural and brain damage.

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CHRONIC CONSUMPTION OF ETHANOL LEADS TO SUBSTANTIAL CELL DAMAGE IN CULTURED RAT ASTROCYTES IN CONDITIONS PROMOTING ACETALDEHYDE ACCUMULATION
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Authors: Montoliu, C., Sancho‐Tello, M., Azorin, I., Burgal, M., Vallés, S., Renau‐Piqueras, J., & Guerri, C.
Affiliations: Instituto de Investigación Sanitaria La Fe (ES)
Corresponding author: Guerri, C.
ORCID: Sancho‐Tello, M.
Vallés, S.
Guerri, C.
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 1995-12
Volume: 65
Issue: 6
Pages: 2561-2570
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1046/j.1471-4159.1995.65062561.x
OpenAlex: W2017219584
Cited by: 218
References: 27
Citations by year: 2026: 5 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 7 · 2012: 11
FWCI: 5.79
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2549 d)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: ethanol, CYP2E1, astrocytes, oxidative stress, reactive oxygen species, glutathione depletion, malondialdehyde, 4-hydroxynonenal, alcohol neurotoxicity, cytoskeletal alterations, glial fibrillary acidic protein, nuclear membrane localization
MeSH terms: Ethanol, Animals, Astrocytes, Cells, Cultured, Cytochrome P-450 Enzyme System, Glutathione, Lipid Peroxides, Microsomes, Oxidoreductases, N-Demethylating, Reactive Oxygen Species, Oxidative Stress, Cytochrome P-450 CYP2E1, Rats

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Ethanol Increases Cytochrome P4502E1 and Induces Oxidative Stress in Astrocytes

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