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Protein Phosphatase 2A Is the Major Enzyme in Brain that Dephosphorylates τ Protein Phosphorylated by Proline‐Directed Protein Kinases or Cyclic AMP‐Dependent Protein Kinase
Abstract
Abstract: The paired helical filament (PHF), which makes up the major fibrous component of the neurofibrillary lesions of Alzheimer's disease, is composed of hyperphosphorylated and abnormally phosphorylated microtubule‐associated protein τ. Previous studies have identified serine and threonine residues phosphorylated in PHF‐τ and have shown that τ can be phosphorylated at several of these sites by proline‐directed protein kinases and cyclic AMP‐dependent protein kinase. Here we have investigated which protein phosphatase activities can dephosphorylate recombinant τ phosphorylated with mitogen‐activated protein kinase, glycogen synthase kinase‐3β, neuronal cdc2‐like kinase, or cyclic AMP‐dependent protein kinase. We show that protein phosphatase 2A is by far the major protein phosphatase activity in brain that dephosphorylates τ phosphorylated in this manner.
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Cited by
Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480
Self-citationRole of tau protein in both physiological and pathological conditions
AVILA, J., LUCAS, J. J., PÉREZ, M., & HERNÁNDEZ, F. (2004) · Physiological Reviews · doi:10.1152/physrev.00024.2003 · Cited by 1,005
Augustinack, J. C., Schneider, A., Mandelkow, E.-M., & Hyman, B. T. (2002) · Acta Neuropathologica · doi:10.1007/s004010100423 · Cited by 998
Liu, F., Grundke‐Iqbal, I., Iqbal, K., & Gong, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04391.x · Cited by 759
Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease
Barage, S. H., & Sonawane, K. D. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.06.008 · Cited by 579
Metadata
- Authors
- Goedert, M., Jakes, R., Qi, Z., Wang, J. H., & Cohen, P.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1995-12
- Volume
- 65
- Issue
- 6
- Pages
- 2804-2807
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2148613196
- Cited by
- 171
- References
- 0
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Protein Phosphatase 2A Is the Major Enzyme in Brain that Dephosphorylates τ Protein Phosphorylated by Proline‐Directed Protein Kinases or Cyclic AMP‐Dependent Protein Kinase. https://app.cochat.ai/papers/10.1046/j.1471-4159.1995.65062804.x
- The paper
- Goedert, M., Jakes, R., Qi, Z., Wang, J. H., & Cohen, P. (1995). Protein Phosphatase 2A Is the Major Enzyme in Brain that Dephosphorylates τ Protein Phosphorylated by Proline‐Directed Protein Kinases or Cyclic AMP‐Dependent Protein Kinase. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.1995.65062804.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
