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Presynaptic Nicotinic Modulation of Dopamine Release in the Three Ascending Pathways Studied by In Vivo Microdialysis: Comparison of Naive and Chronic Nicotine‐Treated Rats
Abstract
Abstract: The modulation of dopamine release by presynaptic nicotinic receptors in vitro is well established, but the significance of this effect in vivo is unclear. We have characterised the effect of nicotine, locally applied via a microdialysis probe, on dopamine release from the terminal regions of three ascending dopaminergic pathways in conscious, freely moving rats. Nicotine caused a dose‐dependent increase in dopamine release in the striatum, the nucleus accumbens, and, to a lesser extent, the frontal cortex. Metabolite levels were unaltered by any concentration of nicotine. Prior administration of mecamylamine via the probe abolished the nicotine‐evoked increase in dopamine release, confirming the mediation of nicotinic receptors. The dose dependence of mecamylamine‐sensitive, nicotine‐evoked dopamine release was similar in all three brain regions. However, 10−5M tetrodotoxin totally blocked nicotine‐stimulated dopamine release in the striatum and the accumbens but not the cortex. Daily subcutaneous injections of nicotine (0.4 mg kg−1 for 7 days) increased the response to a subsequent local application of nicotine in the striatum, and a similar trend was found in the other brain areas. The same daily dose of nicotine given as a continuous infusion had no effect, whereas infusion of 4 mg kg−1 day−1 increased the response to a subsequent nicotine challenge. The localisation and regulation of nicotinic receptors in the terminal fields of dopaminergic pathways are discussed.
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“These effects on dopaminergic terminals extend and confirm other reports that chronic nicotine increases nicotine-induced dopamine release (25,26) and upregulates receptors in striatum (5).”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [25]
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Hilmas, C. J., Pereira, E. F. R., Alkondon, M., Rassoulpour, A., Schwarcz, R. M., & Albuquerque, E. X. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07463.2001 · Cited by 875
Neuronal nicotinic receptors in the human brain
Paterson, D., & Nordberg, A. K. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00045-3 · Cited by 792
Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum
Zhou, F.-M., Liang, Y., & Dani, J. A. (2001) · Nature Neuroscience · doi:10.1038/nn769 · Cited by 585
PRESYNAPTIC IONOTROPIC RECEPTORS AND THE CONTROL OF TRANSMITTER RELEASE
MacDermott, A. B., Role, L. W., & Siegelbaum, S. A. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.443 · Cited by 570
Millan, M. J. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.006 · Cited by 569
Metadata
- Authors
- Marshall, D. L., Redfern, P. H., & Wonnacott, S.
- Affiliations
- University of Bath (GB)
- Corresponding author
- Wonnacott, Susan
- ORCID
- Wonnacott, Susan
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1997-04
- Volume
- 68
- Issue
- 4
- Pages
- 1511-1519
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2090796082
- Cited by
- 284
- References
- 0
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 7 · 2018: 8 · 2017: 1 · 2016: 7 · 2015: 9 · 2014: 3 · 2013: 13 · 2012: 10
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- presynaptic nicotinic acetylcholine receptors, dopamine release, nicotine, striatum, nucleus accumbens, frontal cortex, mecamylamine, tetrodotoxin, chronic nicotine treatment, nicotine tolerance, dopamine metabolites, in vivo microdialysis
- MeSH terms
- Animals, Dopamine, Male, Mecamylamine, Neurons, Nicotine, Tetrodotoxin, Time Factors, Rats, Sprague-Dawley, Microdialysis, Presynaptic Terminals, Nicotinic Agonists, Nicotinic Antagonists, Rats
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