The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Progesterone Stimulates the Activity of the Promoters of Peripheral Myelin Protein‐22 and Protein Zero Genes in Schwann Cells
Abstract
Abstract: To understand better the mechanisms by which progesterone (PROG) promotes myelination in the PNS, cultured rat Schwann cells were transiently transfected with reporter constructs in which luciferase expression was controlled by the promoter region of either the peripheral myelin protein‐22 (PMP22) or the protein zero (P 0) genes. PROG stimulated the P 0 promoter and promoter 1, but not promoter 2, of PMP22. The effect of PROG was specific, as estradiol and testosterone only weakly activated promoters. Dose‐response curves for stimulation of both promoter constructs by PROG were biphasic. RU486, a PROG antagonist, did not abolish the effect of PROG, but stimulated promoter activities by itself. In the human carcinoma cell line T47D expressing high levels of PROG receptor, PROG did not stimulate the P 0 and PMP22 promoters, whereas the promoter region of the mouse mammary tumor virus was fully activated. Thus, the activation by PROG of promoter activity of two peripheral myelin protein genes is Schwann‐cell specific.
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Citations
Cites
Progesterone synthesis and myelin formation by Schwann cells
Koenig, H. L., Schumacher, M., Ferzaz, B., Thi, A. N. D., Ressouches, A., Guennoun, R., Jung-Testas, I., Robel, P., Akwa, Y., & Baulieu, E.-E. (1995) · Science · doi:10.1126/science.7770777 · Cited by 480
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Cited by
Neurosteroids: biosynthesis and function of these novel neuromodulators
Compagnone, N. A., & Mellon, S. H. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0188 · Cited by 820
Neurosteroids: biochemistry and clinical significance
Mellon, S. H., & Griffin, L. D. (2002) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(01)00503-3 · Cited by 538
Neurosteroids: Beginning of the story
Baulieu, E. E., Robel, P., & Schumacher, M. (2001) · International Review of Neurobiology · doi:10.1016/s0074-7742(01)46057-0 · Cited by 352
Self-citationMyelin synthesis in the peripheral nervous system
Garbay, B. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00049-0 · Cited by 314
Sereda, M. W., Meyer zu Hörste, G., Suter, U., Uzma, N., & Nave, K.-A. (2003) · Nature Medicine · doi:10.1038/nm957 · Cited by 310
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Metadata
- Authors
- Désarnaud, F., Do Thi, A. N., Brown, A. M., Lemke, G., Suter, U., Baulieu, E., & Schumacher, M.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1998-10
- Volume
- 71
- Issue
- 4
- Pages
- 1765-1768
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2038205842
- Cited by
- 179
- References
- 1
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Désarnaud, F., Do Thi, A. N., Brown, A. M., Lemke, G., Suter, U., Baulieu, E., & Schumacher, M. (1998). Progesterone Stimulates the Activity of the Promoters of Peripheral Myelin Protein‐22 and Protein Zero Genes in Schwann Cells. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.1998.71041765.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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