Amyloid β and Amylin Fibrils Induce Increases in Proinflammatory Cytokine and Chemokine Production by THP‐1 Cells and Murine Microglia

Yates, Stephen L.; Burgess, Loyd H.; Kocsis‐Angle, June; Antal, Joyce M.; Dority, Michael D.; Embury, Paula B.; Piotrkowski, Anthony M.; Brunden, Kurt R.

doi:10.1046/j.1471-4159.2000.0741017.x

Amyloid β and Amylin Fibrils Induce Increases in Proinflammatory Cytokine and Chemokine Production by THP‐1 Cells and Murine Microglia

Activated microglia surrounding amyloid β‐containing senile plaques synthesize interleukin‐1, an inflammatory cytokine that has been postulated to contribute to Alzheimer's disease pathology. Studies have demonstrated that amyloid β treatment causes increased cytokine release in microglia and rel…