Cited by 175Alzheimer's disease research and treatmentsTelomeres, Telomerase, and SenescenceNeuroinflammation and Neurodegeneration Mechanisms

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The Catalytic Subunit of Telomerase Protects Neurons Against Amyloid β‐Peptide‐Induced Apoptosis

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Zhu, Haiyan, Fu, Weiming, Mattson, Mark P.·2000·Journal of Neurochemistry

DOI 10.1046/j.1471-4159.2000.0750117.x

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Abstract

Abstract : The catalytic subunit of telomerase (TERT) is a specialized reverse transcriptase that has been associated with cell immortalization and cancer. It was reported recently that TERT is expressed in neurons throughout the brain in embryonic and early postnatal development, but is absent from neurons in the adult brain. We now report that suppression of TERT levels and function in embryonic mouse hippocampal neurons in culture using antisense technology and the telomerase inhibitor 3' ‐azido‐2' 3' ‐dideoxythymidine significantly increases their vulnerability to cell death induced by amyloid β‐peptide, a neurotoxic protein believed to promote neuronal degeneration in Alzheimer's disease. Neurons in which TERT levels were reduced exhibited increased levels of oxidative stress and mitochondrial dysfunction following exposure to amyloid β‐peptide. Overexpression of TERT in pheochromocytoma cells resulted in decreased vulnerability to amyloid β‐peptide‐induced apoptosis. Our findings demonstrate a neuroprotective function of TERT in an experimental model relevant to Alzheimer's disease, and suggest the possibility that restoration of TERT expression in neurons in the adult brain may protect against age‐related neurodegeneration.

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
The RNA Component of Human Telomerase
Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227
Hydrogen peroxide mediates amyloid β protein toxicity
Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
Greider, C. W., & Blackburn, E. H. (1989) · Nature · doi:10.1038/337331a0 · Cited by 1,643
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
Mattson, M. P., Cheng, B., Davis, D. G., Bryant, K., Lieberburg, I. M., & Rydel, R. E. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00376.1992 · Cited by 1,633
Self-citation
Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase
Lingner, J., Hughes, T. R., Shevchenko, A., Mann, M., Lundblad, V., & Cech, T. R. (1997) · Science · doi:10.1126/science.276.5312.561 · Cited by 1,269
Control of telomere length by the human telomeric protein TRF1
van Steensel, B., & de Lange, T. (1997) · Nature · doi:10.1038/385740a0 · Cited by 1,219
Telomere loss: mitotic clock or genetic time bomb?
Harley, C. B. (1991) · Mutation Research/DNAging · doi:10.1016/0921-8734(91)90018-7 · Cited by 1,139
p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., & de Lange, T. (1999) · Science · doi:10.1126/science.283.5406.1321 · Cited by 1,086

Show all 64 references

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Pericuesta, E., Ramírez, M. Á., Villa, A., Relaño-Ginés, A., Torres, J. M., Nieto, M., Pintado, B., & Gutiérrez‐Adán, A. (2006) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-4-5 · Cited by 24
Telomerase down‐regulation does not mediate PC12 pheochromocytoma cell differentiation induced by NGF, but requires MAP kinase signalling
Li, H., Pinto, A. R., Duan, W., Li, J., Toh, B., & Liu, J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03439.x · Cited by 24
“(2005) 95, 891–901 exposure to amyloid b-peptide, whereas TERT overexpression in PC12 cells results in decreased vulnerability to stressand amyloid b-peptide-induced apoptosis (Fu et al. 1999, 2000; Zhu et al. 2000; Zhang et al. 2003).”
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Hehar, H., Ma, I. W. Y., & Mychasiuk, R. (2017) · Scientific Reports · doi:10.1038/s41598-017-07784-7 · Cited by 22
The tamoxifen-induced suppression of telomerase activity in the human hepatoblastoma cell line HepG2: a result of post-translational regulation
Brandt, S., Heller, H., Schuster, K., & Grote, J. (2004) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-004-0589-0 · Cited by 21
Regulation and Effects of Modulation of Telomerase Reverse Transcriptase Expression in Primordial Germ Cells During Development1
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Manipulating cognitive reserve: Pre-injury environmental conditions influence the severity of concussion symptomology, gene expression, and response to melatonin treatment in rats
Yamakawa, G. R., Salberg, S., Barlow, K. M., Brooks, B. L., Esser, M. J., Yeates, K. O., & Mychasiuk, R. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.06.001 · Cited by 20
“Increases in BDNF, Oxy-R and TERT support this theory, as they are involved in neuroprotection, neuroplasticity and cellular homeostasis (Mattson, 2000; Zhu et al., 2001; Horch and Katz, 2002; Kang et al., 2004; Griesbach et al., 2009; Ceanga et al., 2010).”
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Tissue formation and tissue engineering through host cell recruitment or a potential injectable cell‐based biocomposite with replicative potential: Molecular mechanisms controlling cellular senescence and the involvement of controlled transient telomerase activation therapies
Babizhayev, M. A., & Yegorov, Y. E. (2015) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35515 · Cited by 20
A human TERT C-terminal polypeptide sensitizes HeLa cells to H2O2-induced senescence without affecting telomerase enzymatic activity
Huang, J., Bai, Y. X., Han, S. W., Ng, S. S., Jing, D. D., Yu, W. B. C., Huang, C., Kung, H., & Lin, M. C. M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)03049-8 · Cited by 19
Telomerase and neuronal marker status of differentiated NT2 and SK‐N‐SH human neuronal cells and primary human neurons
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“For example, expression of telomerase in rodent cell lines and mouse hippocampal neurons increases resistance to DNA-damaging agents and amyloid b-peptide, a neurotoxic protein linked to Alzheimer’s disease (Zhu et al., 2000; Lu et al., 2001).”
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Telomeres, Telomerase, Stress, and Aging
Lin, J., Epel, E. S., & Blackburn, E. H. (2009) · Wiley eBooks · doi:10.1002/9780470478509.neubb002065 · Cited by 19
Inhibition of Proliferation and Induction of Apoptosis in Human Renal Carcinoma Cells by Anti-telomerase Small Interfering RNAs
Zheng, J., Sun, Y., Pei, D., Liu, J.-J., Chen, J., Li, W., Sun, X., Shi, Q.-D., Han, R., & Teng-xiang, M. (2006) · Acta Biochimica et Biophysica Sinica · doi:10.1111/j.1745-7270.2006.00182.x · Cited by 17
Distinct roles of telomerase activity in age-related chronic diseases: An update literature review
Wang, X., Deng, H., Lin, J., Zhang, K., Ni, J., Li, L., & Fan, G. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115553 · Cited by 19
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Antitumor mechanism of antisense cantide targeting human telomerase reverse transcriptase
Du, Q. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i9.2030 · Cited by 17
Mechanisms of Neuronal Apoptosis and Excitotoxicity
Mattson, M. P. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-106-0_1 · Cited by 17
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Meessen, S., Najjar, G., Azoitei, A., Iben, S., Bolenz, C., & Güneş, Ç. (2022) · Cancers · doi:10.3390/cancers14092205 · Cited by 9
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Self-citation
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Ishikawa, M., Mizukami, K., Iwakiri, M., Kamma, H., Ikonomović, M. D., DeKosky, S. T., & Asada, T. (2004) · Neuroscience Research · doi:10.1016/j.neures.2004.08.013 · Cited by 6
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(2000) · Ageing International · doi:10.1007/s12126-000-1003-0 · Cited by 6
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“13 In AD, abnormal proteolytic processing of the amyloid precursor protein results in the production and deposition of neurotoxic forms of ABP.”
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“Up regulation of the enzyme telomerase, to add telomeres, is proposed as a potential strategy for aging and AD because overexpression of TERT can protect neurons from amyloid induced apoptosis [42-49].”
Background
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Wang, J., Shi, P., Dong, K., Yan, Z., Ren, J., & Qu, X. (2017) · Materials Today · doi:10.1016/j.mattod.2017.07.004 · Cited by 4
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“Ex vivo studies have suggested that while telomere damage induces neuronal cell death [108], the activation of telomerase can enhance neuronal cell viability [109, 110].”
Background
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Iannilli, F., Zalfa, F., Gärtner, A., Bagni, C., & Dotti, C. G. (2013) · PLoS ONE · doi:10.1371/annotation/e2d5d0e4-fb3a-4d53-a2de-99cd8d045d1c · Cited by 3
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Iben, S., & Güneş, Ç. (2015) · Telomere and Telomerase · doi:10.14800/tt.433 · Cited by 2
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Background
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Saretzki, G. C. (2011) · InTech eBooks · doi:10.5772/15307 · Cited by 2
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Fu, Y., Bu, G., Kanekiyo, T., & Zhao, J. (2021) · Nature Aging · doi:10.1038/s43587-021-00145-0 · Cited by 2
Cellular and Molecular Mechanisms Underlying Synaptic Degeneration and Neuronal Death in Alzheimer's Disease
Mattson, M. P., Pedersen, W. A., & Culmsee, C. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-106-0_6 · Cited by 2
Self-citation
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Mattson, M. P., Fu, W., & Zhang, P. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)08007-5 · Cited by 2
Self-citation
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Bellot, G. L., & Wang, Y. (2013) · InTech eBooks · doi:10.5772/48583 · Cited by 2
“(BDNF) (Fu et al., 2002; Kang et al., 2004; Zhu et al., 2000).”
New Discoveries Alter the Landscape Potential of Anti-Aging Therapy
Sonneborn, J. S. (2015) · Journal of Aging Science · doi:10.4172/2329-8847.1000143
“The absence of TERT increases ROS generation and oxidative damage in neurons induced by pathological amyloid β peptide induced apoptosis [96,97], ischemic brain injury, neurotoxicity [98].”
Background
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Yoshida, K., Yoshizato, A., Kakuo, S., Tahara, H., & Ide, T. (2004) · Tissue culture research communications : the journal of experimental & applied cell culture research · doi:10.11418/jtca1981.23.2_59 · Cited by 1
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Allen, H. K., & Klingelhutz, A. J. (2003) · Papillomavirus Report · doi:10.1179/095741903225001598 · Cited by 1
Review Article Free Radical Theory of Aging: Implications in Male Infertility
Desai, N. R., Sabanegh, E., Kim, T. S., & Agarwal, A. K. (2009) · Cited by 1
Telomerase in brain development and neurodegenerative disorders
Mattson, M. P., Rao, M. S., Fu, W., & Klapper, W. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)08009-9
Self-citation
Common Male Infertility Disorders: Aging
Pasqualotto, F. F., Borges, E., & Pasqualotto, E. B. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3335-4_30
“[ 66 ] suggested that decreased activity of catalytic subunits of telomerase (mTERT) increases neuronal cell susceptibility to oxidative stress.”
Background
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Diehl, M. C., Elmore, L. W., & Holt, S. E. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-879-9_4
Telomere analysis of normal and neoplastic hematopoietic cells : studies focusing on fluorescence in situ hybridization and flow cytometry.
Hultdin, M. (2003) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Telomery i telomeraza w komórkach roślinnych
Boczkowska, M., & Puchalski, J. (2012)
Estudo dos telômeros em tecido hipocampal de camundongos submetidos a um estresse psicossocial prolongado
Paulo, S. (2008)
Funktionen der alternsrelevanten Proteine Thioredoxin-1 und Telomerase Reverse Transkriptase in umweltinduzierten Prozessen
Büchner, N. (2010) · Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver
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Lysko, M. D. (2016) · TSpace (University of Toronto)
Investigating the Protective Effects of Telomerase Reverse Transcriptase on Neuronal Metabolism and Resistance to Amyloid-beta
Singh, O. (2017) · Scholarship@Western (Western University)
In vivo and in vitro analysis on the effect of LRP/LR on alzheimer's disease related proteins, TERT expression and telomerase activity in alzheimer's disease models
Bignoux, M. J. (2018)
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Soares, J. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/fgzz-7e09
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Cuttler, K., Bignoux, M. J., Otgaar, T. C., Chigumba, S., Ferreira, E., & Weiss, S. F. T. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.14.905661
Common Male Infertility Disorders: Aging
Pasqualotto, F. F., Borges, E., & Pasqualotto, E. B. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9158-3_11
Anti-Aging Medicine Literature Watch
Pawelec, G. (2000) · Rejuvenation Research · doi:10.1089/rej.1.2000.3.453
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(2002) · Rejuvenation Research · doi:10.1089/109454502763485502
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Samy, M. (2010) · theses.fr (ABES) · doi:10.70675/07050b7dz1056z4e65za6f1z34cea95a398b
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Ferrandon, S. (2013) · theses.fr (ABES) · doi:10.70675/1f7a8f9az467az443cz882dz3a373535811d
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Billard, P. (2021) · theses.fr (ABES) · doi:10.70675/7d145f6az2700z4c8bzad56z3286d493fb31
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Czapiewski, R. (2013)
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Authors: Zhu, H., Fu, W., & Mattson, M. P.
Affiliations: University of Kentucky (US)
National Institutes of Health (US)
ORCID: Zhu, Haiyan
Fu, Weiming
Mattson, Mark P.
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2000-07
Volume: 75
Issue: 1
Pages: 117-124
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1046/j.1471-4159.2000.0750117.x
OpenAlex: W2071245320
Cited by: 175
References: 64
Citations by year: 2024: 2 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 7 · 2013: 10 · 2012: 3
FWCI: 7.98
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 542 d)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: telomerase reverse transcriptase, amyloid-beta, neuronal apoptosis, neuroprotection, Alzheimer's disease, oxidative stress, mitochondrial dysfunction, hippocampal neurons, telomerase inhibitors, zidovudine, age-related neurodegeneration
MeSH terms: Alzheimer Disease, Animals, Cells, Cultured, DNA-Binding Proteins, Embryo, Mammalian, Enzyme Inhibitors, Hippocampus, Immunohistochemistry, Mitochondria, Neurons, RNA, Gene Expression, Amyloid beta-Peptides, Oligonucleotides, Antisense, PC12 Cells, Apoptosis, Oxidative Stress, Telomerase, Catalytic Domain, Mice, Rats

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The Catalytic Subunit of Telomerase Protects Neurons Against Amyloid β‐Peptide‐Induced Apoptosis

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