The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo
Abstract
Lithium has been demonstrated to increase neurogenesis in the dentate gyrus of rodent hippocampus. The present study was undertaken to investigate the effects of lithium on the proliferation and differentiation of rat neural progenitor cells in hippocampus both in vitro and in vivo. Lithium chloride (1–3 m m) produced a significant increase in the number of bromodeoxyuridine (BrdU)‐positive cells in high‐density cultures, but did not increase clonal size in low‐density cultures. Lithium chloride at 1 m m(within the therapeutic range) also increased the number of cells double‐labeled with BrdU antibody and TuJ1 (a class III β‐tubulin antibody) in high‐density cultures and the number of TuJ1‐positive cells in a clone of low‐density cultures, whereas it decreased the number of glial fibrillary acidic protein‐positive cells in both cultures. These results suggest that lithium selectively increased differentiation of neuronal progenitors. These actions of lithium appeared to enhance a neuronal subtype, calbindin D28k‐positive cells, and involved a phosphorylated extracellular signal‐regulated kinase and phosphorylated cyclic AMP response element‐binding protein‐dependent pathway both in vitro and in vivo. These findings suggest that lithium in therapeutic amounts may elicit its beneficial effects via facilitation of neural progenitor differentiation toward a calbindin D28k‐positive neuronal cell type.
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Citations
Cites
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Course of illness, hippocampal function, and hippocampal volume in major depression
MacQueen, G. M., Campbell, S., McEwen, B. S., Macdonald, K., Amano, S., Joffe, R. T., Nahmias, C., & Young, L. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337481100 · Cited by 980
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Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide
Savitz, J., & Drevets, W. C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.004 · Cited by 494
Forlenza, O. V., De-Paula, V. J. R., & Diniz, B. S. O. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn5000309 · Cited by 332
Review of Lithium Effects on Brain and Blood
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The role of hippocampus in the pathophysiology of bipolar disorder
Frey, B. N., Andreazza, A. C., Nery, F. G., Martins, M. R., Quevedo, J., Soares, J. C., & Kapczinski, F. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282df3cde · Cited by 162
Metadata
- Authors
- Kim, J. S., Chang, M., Yu, I. T., Kim, J. H., Lee, S., Lee, Y., & Son, H.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2004-03-22
- Volume
- 89
- Issue
- 2
- Pages
- 324-336
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1530114072
- Cited by
- 180
- References
- 2
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, J. S., Chang, M., Yu, I. T., Kim, J. H., Lee, S., Lee, Y., & Son, H. (2004). Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.2004.02329.x
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