Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility?
Abstract
Summary: Levels of iron are increased in the brains of Parkinson's disease (PD) patients compared to age‐matched controls. This has been postulated to contribute to progression of the disease via several mechanisms including exacerbation of oxidative stress, initiation of inflammatory responses and triggering of Lewy body formation. In this minireview, we examine the putative role of iron in PD and its pharmacological chelation as a prospective therapeutic for the disease.
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TfR2 has a lower affinity for Fe-Tf than does TfR1.
“TfR2 has a lower affinity for Fe-Tf than does TfR1 (160, 320).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [160]
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References 31 · Cited by 44
- Authors
- Kaur, D., & Andersen, J. K.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Andersen, Julie K.
- ORCID
- Andersen, Julie K.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2002-09-15
- Volume
- 1
- Issue
- 1
- Pages
- 17-21
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W1991242670
- Cited by
- 44
- References
- 31
- Citations by year
- 2021: 2 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- Parkinson's disease, iron chelators, brain iron accumulation, oxidative stress, neuroinflammation, Lewy bodies, iron chelation therapy, neurodegeneration
- MeSH terms
- Animals, Encephalitis, Humans, Iron, Iron Chelating Agents, Neurons, Parkinson Disease, Substantia Nigra, Chelation Therapy, Lewy Bodies, Oxidative Stress
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