Mitochondria and aging: A role for the permeability transition?
Open accessAbstract
When mitochondria are subjected to oxidative stress and relatively high [Ca2+], they undergo a "permeability transition" in which the inner membrane becomes freely permeable to low-molecular-weight solutes. This phenomenon reflects reversible deformation of the adenine nucleotide translocase, the loss of its native gating properties and the stabilization of the deformed state by cyclophilin-D. The permeability transition may be a factor in cell dysfunction associated with aging. This can manifest in a number of ways ranging, in the most severe, from impaired energy transduction and compromised viability to more subtle influences on the propagation of Ca2+ signals. This article critically examines data relevant to this issue.
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Direct evidence for enhanced mPTP activation in aging and neurodegenerative disease is extensive.
“Indeed, direct evidence for enhanced mPTP activation in aging and neurodegenerative disease is extensive.”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [41]
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References 36 · Cited by 101
- Authors
- Crompton, M.
- Affiliations
- University College London (GB)
- Corresponding author
- Crompton, M.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2003-12-15
- Volume
- 3
- Issue
- 1
- Pages
- 3-6
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W1982577723
- Cited by
- 101
- References
- 36
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 6 · 2012: 7
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- mitochondrial permeability transition, aging, adenine nucleotide translocase, cyclophilin D, oxidative stress, calcium signaling, mitochondrial energy transduction, mitochondrial dysfunction, inner mitochondrial membrane permeability
- MeSH terms
- Mitochondrial Permeability Transition Pore, Mitochondrial ADP, ATP Translocases, Aging, Animals, Calcium, Humans, Intracellular Membranes, Ion Channels, Mitochondria, Calcium Signaling, Mitochondrial Membrane Transport Proteins
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