The Melanocortin 5 Receptor is Expressed in Human Sebaceous Glands and Rat Preputial Cells
Open accessAbstract
Melanocortins regulate pigmentation, adrenal hormone secretion, immune functions, lipid metabolism, and feeding behaviors in rodents. These peptides include adrenocorticotrophic hormone, melanocyte stimulating hormone, beta-lipotrophin, and the endorphins. Lipid metabolism in sebaceous glands and preputial glands of rodents is regulated by alpha-melanocyte stimulating hormone, the major agonist for melanocortin receptors. Five melanocortin receptor subtypes have been identified that differ in their tissue localization and affinities for melanocortin ligands. Targeted disruption of the melanocortin 5 receptor in transgenic mice results in widespread dysfunction of exocrine glands, including a marked decrease in sebum production. A role for melanocortins in the modulation of human sebum production has not been established. The goal of this study is to determine which melanocortin receptors are expressed in human sebaceous glands. Messenger RNA was isolated from human sebaceous glands and the reverse transcriptase polymerase chain reaction was performed using primers specific for each of the melanocortin receptor subtypes. Transcripts were detected for the melanocortin 5 receptor. A polyclonal chicken antihuman antibody to the melanocortin 5 receptor localized to sebaceous glands, eccrine glands, hair follicles, and epidermis in human skin, rat skin, cultured human sebocytes, and rat preputial cells. Presence of the melanocortin 5 receptor protein in human sebaceous glands and rat preputial glands was further verified by Western blotting. These data support further investigation of the role of melanocortins in the regulation of human sebum production and support the use of the rat preputial system as an experimental model in sebaceous gland physiology.
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Human sebocytes express melanocortin 5 receptor (MC5R), which is involved in sebocyte differentiation and lipogenesis.
“Human sebocytes also express melanocortin 5 receptor (MC5R), which is involved in sebocyte differentiation and lipogenesis.87,88”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [87]
The Discussion reports MC5R expression in human sebaceous glands and cultured human sebocytes. It discusses differentiation as a subject for further study, but explicitly says that MC5R’s role in regulating human sebum production has not been established. It therefore does not establish that MC5R is involved in human sebocyte differentiation or lipogenesis. (LLM, conf=0.91)
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References 36 · Cited by 90
Research works printed but not linked: 1
- Cooper MF, Bowden PW, Meddis D, Thody AJ, Shuster S: Effects of testosterone and alpha-melanocyte-stimulating hormone on preputial-gland (sebaceous) activity. Biochem Soc Transactions 4:798±800, 1976
- Authors
- Thiboutot, D., Sivarajah, A., Gilliland, K., Cong, Z., & Clawson, G.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Thiboutot, Diane
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 115
- Issue
- 4
- Pages
- 614-619
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1992581317
- Cited by
- 90
- References
- 36
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 1 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k08ar002018-03)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (K08AR02018)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- MC5R, sebaceous glands, preputial gland, sebum production, melanocortin peptides, alpha-melanocyte-stimulating hormone, sebocytes, receptor expression, human skin, eccrine sweat glands, hair follicle, epidermis, lipid metabolism
- MeSH terms
- Animals, Antibody Specificity, Humans, Immunohistochemistry, Male, Penis, Sebaceous Glands, Sebum, Transcription, Genetic, Blotting, Western, Receptors, Corticotropin, Reverse Transcriptase Polymerase Chain Reaction, Receptors, Melanocortin, Rats
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