The DOI matches its Crossref record; 45 of the 47 references it cites were found in a registry or an index.
Vitamin A Antagonizes Decreased Cell Growth and Elevated Collagen-Degrading Matrix Metalloproteinases and Stimulates Collagen Accumulation in Naturally Aged Human Skin1
Open accessAbstract
Damage to human skin due to ultraviolet light from the sun (photoaging) and damage occurring as a consequence of the passage of time (chronologic or natural aging) are considered to be distinct entities. Photoaging is caused in part by damage to skin connective tissue by increased elaboration of collagen-degrading matrix metalloproteinases, and by reduced collagen synthesis. As matrix metalloproteinase levels are known to rise in fibroblasts as a function of age, and as oxidant stress is believed to underlie changes associated with both photoaging and natural aging, we determined whether natural skin aging, like photoaging, gives rise to increased matrix metalloproteinases and reduced collagen synthesis. In addition, we determined whether topical vitamin A (retinol) could stimulate new collagen deposition in sun-protected aged skin, as it does in photoaged skin. Sun-protected skin samples were obtained from 72 individuals in four age groups: 18-29 y, 30-59 y, 60-79 y, and 80+ y. Histologic and cellular markers of connective tissue abnormalities were significantly elevated in the 60-79 y and 80+ y groups, compared with the two younger age groups. Increased matrix metalloproteinase levels and decreased collagen synthesis/expression were associated with this connective tissue damage. In a separate group of 53 individuals (80+ y of age), topical application of 1% vitamin A for 7 d increased fibroblast growth and collagen synthesis, and concomitantly reduced the levels of matrix-degrading matrix metalloproteinases. Our findings indicate that naturally aged, sun-protected skin and photoaged skin share important molecular features including connective tissue damage, elevated matrix metalloproteinase levels, and reduced collagen production. In addition, vitamin A treatment reduces matrix metalloproteinase expression and stimulates collagen synthesis in naturally aged, sun-protected skin, as it does in photoaged skin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This process influences the condition of the connective tissue of the dermis, improving its firmness, hydration and elasticity [35,42].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [42]
In the citing paper
“Retinoids and all biologically active forms of vitamin A also promote the remodeling of reticulin fibers and synthesis of a new capillary network in the dermis.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [42]
In the citing paper
“After penetrating the dermis, retinoids increase the synthesis of elastin and collagen by stimulating the fibroblasts [42].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [42]
In the citing paper
“Retinoids protect collagen against the destruction induced by MMPs, as well as enhancing the synthesis of tissue inhibitors of metalloproteinases (TIMPs) [32,42].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [42]
In the citing paper
“Varani et al. observed that topical vitamin A (retinol) reduced MMP expression and increased fibroblast growth and collagen synthesis in naturally aged, as it did in photoaged, skin [42].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [42]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Oxidative Stress, Caloric Restriction, and Aging
Sohal, R. S., & Weindruch, R. H. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,133
Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light
Fisher, G. J., Wang, Z., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711133372003 · Cited by 1,501
Self-citationMolecular basis of sun-induced premature skin ageing and retinoid antagonism
Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z.-Q., Varani, J., Kang, S., & Voorhees, J. J. (1996) · Nature · doi:10.1038/379335a0 · Cited by 1,410
Self-citationPhysiology, Biochemistry, and Molecular Biology of the Skin
Shelley, W. B. (1992) · JAMA · doi:10.1001/jama.1992.03490040129042 · Cited by 791
Topical tretinoin for photoaged skin
Kligman, A. M., Grove, G. L., Hirose, R., & Leyden, J. J. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70242-9 · Cited by 620
Statistical Methods for the Analysis of Biomedical Data
Ziegel, E. R., & Woolson, R. F. (1989) · Technometrics · doi:10.2307/1268847 · Cited by 586
The estimation of two collagens from human dermis by interrupted gel electrophoresis
Sykes, B. C., Puddle, B., Francis, M. J. O., & Smith, R. (1976) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(76)80180-5 · Cited by 560
Topical Tretinoin Improves Photoaged Skin
Weiss, J. (1988) · JAMA · doi:10.1001/jama.1988.03720040019020 · Cited by 490
Restoration of Collagen Formation in Photodamaged Human Skin by Tretinoin (Retinoic Acid)
Griffiths, C. E. M., Russman, A., Majmudar, G., Singer, R. S., Hamilton, T. A., & Voorhees, J. J. (1993) · New England Journal of Medicine · doi:10.1056/nejm199308193290803 · Cited by 471
Structural Alterations in Exposed and Unexposed Aged Skin
Lavker, R. M. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12532763 · Cited by 464
Cited by
Sorted by citations
Items 401–500 of 642
Stability of retinol in liposomes as measured by fluorescence lifetime spectroscopy and FLIM
Sumrall, L., Smith, L., Alhatmi, E., Chmykh, Y. G., Mitchell, D., & Nadeau, J. (2023) · BBA Advances · doi:10.1016/j.bbadva.2023.100088 · Cited by 9
Determinants in the Rate of Skin Aging: Ethnicity, Gender, and Lifestyle Influences
Farage, M. A., Miller, K. W., & Maïbach, H. I. (2009) · Springer eBooks · doi:10.1007/978-3-540-89656-2_92 · Cited by 9
Malcangi, G., Inchingolo, A. M., Inchingolo, A. D., Ferrante, L., Latini, G., Trilli, I., Nardelli, P., Longo, M., Palermo, A., Inchingolo, F., et al. (2025) · Medicina · doi:10.3390/medicina61010084 · Cited by 8
Yoo, M. A., Song, Y. K., Jang, H., Kim, D. M., & Byun, S. Y. (2011) · Korean Journal of Chemical Engineering · doi:10.1007/s11814-010-0430-1 · Cited by 8
Xie, X., Yang, C. H., Ren, M., Hao, S., Zhu, P., & Li, Y. (2012) · Journal of the American Podiatric Medical Association · doi:10.7547/1020299 · Cited by 8
Evaluation and characterization of facial skin aging using optical coherence tomography
Vingan, N. R., Parsa, S., Barillas, J., Culver, A. J., & Kenkel, J. M. (2022) · Lasers in Surgery and Medicine · doi:10.1002/lsm.23611 · Cited by 9
Machinal-Quélin, F., Dieudonné, M., Leneveu, M.-C., Pecquery, R., Castelli, D., Oddos, T., & Giudicelli, Y. (2001) · International Journal of Cosmetic Science · doi:10.1046/j.0412-5463.2001.00097.x · Cited by 8
Recent progress in marine algae research: bridging biodiversity with pharmaceutical potential
Gupta, S., Gaur, P. K., Lal, N., Parveen, R., Kumar, R., & Aashmeen, S. (2025) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-025-01372-w · Cited by 10
Lee, J. W., Peng, L., Jegal, H., Park, N.-J., Bong, S.-K., Lee, J. W., Pyo, J. J., Choi, Y.-S., & Kim, S. (2022) · Applied Biological Chemistry · doi:10.1186/s13765-022-00677-y · Cited by 7
Revitalizing skin, hair, nails, and muscles: Unlocking beauty and wellness with vegan collagen
Warma, S., Warma, H., Merja, A. M., Patel, N., & Patel, M. N. (2024) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16443 · Cited by 7
Piccioni, A., García‐Rodrigo, C. G., Pellegrini, C., Mazzocchetti, G., & Fargnoli, M. C. (2017) · Journal of Cosmetics Dermatological Sciences and Applications · doi:10.4236/jcdsa.2017.71005 · Cited by 8
Indomethacin, a Non-steroidal Anti-inflammatory Drug, Induces Skin Dryness via PPARγ in Mice
Maruyama, K., Goto, K., Hiramoto, K., Tanaka, S., & Ooi, K. (2021) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-00532 · Cited by 7
Ye, Y., Li, Y., Bi, T., & Jiang, L. (2021) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.14621 · Cited by 7
The Extracellular Matrix Protein 1 (ECM1) in Molecular-Based Skin Biology
Oyama, N., & Merregaert, J. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_8 · Cited by 7
N‐Acetylglucosamine modulates function of the skin fibroblasts
Połubińska, A., Cwaliński, J., Baum, E., & Bręborowicz, A. (2013) · International Journal of Cosmetic Science · doi:10.1111/ics.12067 · Cited by 8
Jung, E., Cho, J. Y., Park, D., Kim, M. H., Park, B., Lee, S. Y., & Lee, J. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.10.011 · Cited by 7
Moon, H.-I., Lee, J., Zee, O. P., & Chung, J. H. (2004) · Archives of Pharmacal Research · doi:10.1007/bf02975432 · Cited by 7
The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects
Wang, Y., Wang, M., Xiao, X. S., Pan, P., Li, P., & Huo, J. (2013) · Journal of Cosmetic and Laser Therapy · doi:10.3109/14764172.2012.759234 · Cited by 7
Human skin organ culture for assessment of chemically induced skin damage
Varani, J. (2012) · Expert Review of Dermatology · doi:10.1586/edm.12.24 · Cited by 9
Tretinoin for the treatment of photodamaged skin.
Ting, W. W. (2010) · PubMed · Cited by 7
Topical Delivery Systems Based on Polysaccharide Microspheres
Cattaneo, M. V. (2005) · Elsevier eBooks · doi:10.1016/b978-081551504-3.50017-1 · Cited by 7
Chen, K., Chang, H.-H., Ko, W. S., Wu, C.-L., Chiu, W., Hsieh, C. L., & Peng, R. Y. (2009) · Egyptian Dermatology Online Journal · Cited by 7
The Effect of Rhus verniciflua Stokes Extracts on Photo-Aged Mouse Skin
Hong, H., Jung, M., Choe, S. J., Kim, J.-B., & Choi, E. H. (2017) · Annals of Dermatology · doi:10.5021/ad.2017.29.3.295 · Cited by 7
Does Oral Supplementation With Vitamins A or E Promote Healing of Chronic Wounds?
GRAY, M. L. (2003) · Journal of Wound Ostomy and Continence Nursing · doi:10.1097/00152192-200311000-00003 · Cited by 7
Papazoglou, E. S., Sunkari, C., Neidrauer, M., Klement, J. F., & Uitto, J. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2009.00634.x · Cited by 7
Egg White Lysozyme Promoted Collagen Secreting of Dermal Fibroblasts in Mice
Han, H. B., Li, X., Yu, K., Ma, W., Cao, Z., An, G. F., & Lian, Z. X. (2011) · Asian Journal of Animal and Veterinary Advances · doi:10.3923/ajava.2011.667.677 · Cited by 7
Varani, J., Bhagavathula, N., Nerusu, K. C., Sherzer, H., Fay, K. S., Boitano, A. E., Glick, G. D., Johnson, K. J., Kang, S., & Opipari, A. W. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.075929 · Cited by 7
Proksch, E., Zdzieblik, D., & Oesser, S. (2025) · Cosmetics · doi:10.3390/cosmetics12020079 · Cited by 9
Chang, H., Tao, K., Yang, Y., Wang, Y., Ge, M., Wang, X., Tang, S., & Yu, H. (2025) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.70290 · Cited by 6
Stimulatory effects of collagen production induced by coenzyme Q10 in cultured skin fibroblasts
Mine, Y., Takahashi, T., & Okamoto, T. (2021) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.20-187 · Cited by 7
Rahman, R. T., Koo, B. I., Jang, J., Lee, D. J., Choi, S., Lee, J. B., & Nam, Y. S. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124409 · Cited by 6
Vitamin A and its influence on tumour extracellular matrix
Xie, G., Cao, S., Wang, G., Zhang, X., Zhang, Y., Wu, H., Shen, S., Le, J., Li, K., & Huang, Z. (2025) · Discover Oncology · doi:10.1007/s12672-025-01751-9 · Cited by 6
Ham, S. A., Kang, E. S., Yoo, T., Lim, H. H., Lee, W. J., Hwang, J. S., Paek, K. S., & Seo, H. G. (2015) · Drug Development Research · doi:10.1002/ddr.21240 · Cited by 6
The Extracellular Matrix Protein 1 (ECM1) in Skin Biology: An Update for the Pleiotropic Action
Oyama, N., & Merregaert, J. (2013) · The Open Dermatology Journal · doi:10.2174/1874372201307010029 · Cited by 6
Słoczyńska, K., Gunia‐Krzyżak, A., Żelaszczyk, D., Waszkielewicz, A. M., & Marona, H. (2015) · Acta Biochimica Polonica · doi:10.18388/abp.2014_891 · Cited by 7
Baumann, L., Weisberg, E. M., & Percival, S. L. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-327-1_4 · Cited by 6
Gillbro, J. M., Lundahl, M., Westman, M., Baral, R., Al‐Bader, T., & Mavon, A. (2015) · International Journal of Cosmetic Science · doi:10.1111/ics.12253 · Cited by 6
Formulasi dan Evaluasi Secara Fisikokimia Sedian Krim Anti-Aging
Maya, I., & Mutakin, M. (2017) · Majalah Farmasetika · doi:10.24198/farmasetika.v3i5.23342 · Cited by 6
Sunarwidhi, A. L., Rosyantari, A., Prasedya, E. S., Ardiana, N., Ilhami, B. T. K., Abidin, A. S., Ambana, Y., Kirana, I. P. B. P., Wirasisya, D. G., Anugrah, W., et al. (2021) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/913/1/012103 · Cited by 6
Moon, H.-I., Kwak, J. H., Zee, O. P., & Chung, J. H. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.2173 · Cited by 6
The Baumann Skin Typing System
(2012) · Springer eBooks · doi:10.1007/springerreference_168448 · Cited by 6
Mine, Y., Takahashi, T., & Okamoto, T. (2021) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.20-185 · Cited by 5
Advanced biomaterial strategies for overcoming age-associated wound healing impairments
Dores, R., Rodrigues, T., Carvalho, D. S., Batista, E., Kozak, M., Blanco‐Elices, C., Fernandes, H., & Bimbo, L. M. (2025) · APL Bioengineering · doi:10.1063/5.0251889 · Cited by 5
Chen, W., & Lin, L. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147250 · Cited by 5
D’Ambrosio, L., Greco, M. E., Forte, M., Vecchio, D., Schiavon, S., Nonno, F. D., Tahir, S., Picchio, V., Cozzolino, C., Sarto, G., et al. (2025) · Biology Direct · doi:10.1186/s13062-025-00703-1 · Cited by 6
Kim, S., Kim, Y., Kong, Y., Kim, H.-J., & Kang, J. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.11.028 · Cited by 5
Coherent Raman Scattering Microscopy in Dermatological Imaging
Wang, H., & Evans, C. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802838-4.00011-x · Cited by 5
Unified Approach to the Treatment of Hypertrophic and Atrophic Scars
Chambers, A. (2016) · The American Journal of Cosmetic Surgery · doi:10.1177/0748806816670382 · Cited by 5
Jeon, J., & Lee, S. Y. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08708-7 · Cited by 5
Oh, J. K., Kwon, O., Kim, M. H., Jo, S. J., Han, J. H., Kim, K. H., Eun, H. C., & Chung, J. H. (2012) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2012.09.006 · Cited by 5
Carneiro, S. C. D. S., Cassia, F. D. F., Pascarelli, B. M., Souza, S. O., Ramos‐e‐Silva, M., Filgueira, A. L., Japiassu, M. A., & Takiya, C. M. (2007) · PubMed · Cited by 5
PIE DIABÉTICO: ¿PODEMOS PREVENIRLO?
Oriana Paiva, M., & Nina Rojas, S. (2016) · Revista Médica Clínica Las Condes · doi:10.1016/j.rmclc.2016.04.012 · Cited by 5
Kim, H.-B., Kim, J. Y., An, S., Lee, Y. J., Cho, D., Kim, H.-S., & Bae, S. (2020) · Asian Journal of Beauty and Cosmetology · doi:10.20402/ajbc.2019.0342 · Cited by 5
Rambutan fruits extract in aging skin
Sekar, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818698-5.00031-6 · Cited by 8
Skin Health Improving Effects of Korean Freeze-dried Royal Jelly in Human Keratinocytes
Kim, H. Y., Choi, H. M., Kim, S.-G., Woo, S. O., Moon, H. J., & Han, S. M. (2020) · Asian Journal of Beauty and Cosmetology · doi:10.20402/ajbc.2020.0056 · Cited by 5
The Efficacy of AP Collagen Peptides Intake on Skin Wrinkle, Elasticity, and Hydration Improvement
Jung, K.-M., Yang, M., Kim, S. H., Roh, J., & Kim, W.-G. (2021) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2021.50.5.429 · Cited by 5
Zhou, B., Song, W., Li, C., Deng, Z., Pan, J., Chen, S., Zhong, Q., & Qian, G.-Y. (2022) · Aquaculture Research · doi:10.1111/are.15874 · Cited by 5
The Role of Estrogen Deficiency in Skin Aging and Wound Healing
Saville, C. R., & Hardman, M. J. (2014) · Springer eBooks · doi:10.1007/978-3-662-44080-3_6 · Cited by 5
Skin in Osteogenesis Imperfecta
Chien, A. L.-L., Mu, E. W., & Kang, S. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397165-4.00030-7 · Cited by 5
The role of local retinoids in eliminating signs of skin aging
Albanova, V. I. (2021) · Vestnik dermatologii i venerologii · doi:10.25208/vdv1220 · Cited by 5
Sakura, M., Chiba, Y., Kamiya, E., Furukawa, A., Kawamura, N., Niwa, M., Takeuchi, M., Enokido, Y., & Hosokawa, M. (2014) · Modern Research in Inflammation · doi:10.4236/mri.2014.33010 · Cited by 5
Aslam, M. N., Warner, R. L., Bhagavathula, N., Ginsburg, I., & Varani, J. (2010) · Archives of Dermatological Research · doi:10.1007/s00403-010-1066-z · Cited by 5
Synthesis and Biological Evaluation of Sulfur-Containing Cinnamate and Salicylate Derivatives
Chiang, C., Chang, T., Tsai, H., & Hsu, L. (2008) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.56.369 · Cited by 5
Chowdhury, N. U., Farooq, T., & Abdullah, S. (2016) · Molecular Enzymology and Drug Targets · doi:10.21767/2572-5475.10019 · Cited by 5
Chien, A. L.-L., Qi, J., Grandhi, R., Harris-Tryon, T. A., Kim, N., Jang, M. S., Olowoyeye, O., Kuhn, D. M., Leung, S. G., Rainer, B. M., et al. (2018) · Journal of the National Medical Association · doi:10.1016/j.jnma.2018.01.005 · Cited by 5
Evaluation of Gene Expression and In Vitro Enzyme Study for Antiaging Effect of Crocin and Lutein
Naik, A. A., Gadgoli, C. H., & Naik, A. B. (2019) · The Natural Products Journal · doi:10.2174/2210315509666190801162217 · Cited by 5
Reuther, T., & Kerscher, M. J. (2004) · Der Hautarzt · doi:10.1007/s00105-004-0758-8 · Cited by 5
Maya, I., Sriwidodo, S., Mita, S. R., Kusumawulan, C. K., Putriana, N. A., Amalia, E., Aulia, R. N., Sofyan, H. N., Dzulfannazhir, F., & Nugraha, M. H. (2024) · Cosmetics · doi:10.3390/cosmetics11060226 · Cited by 8
Park, S., Baek, S., Shin, H.-J., Hwang, J. Y., Yoo, D. S., Seo, D. B., & Bae, S. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17121560 · Cited by 5
Vitamins and the skin: Vitamin A and retinoids in dermatology
Dessinioti, C., & Katsambas, A. (2026) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2026.02.005 · Cited by 4
Sołdacka, D., Podgórska, M., & Barańska‐Rybak, W. (2023) · Dermatologic Therapy · doi:10.1155/2023/5588525 · Cited by 5
LincRNA-EPS Promotes Proliferation of Aged Dermal Fibroblast by Inducing CCND1
Zhang, L., Wang, I. C., Meng, S., & Xu, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147677 · Cited by 4
Şahin, O., Kanbolat, Ş., Çolak, N. U., Badem, M., Subaş, T., Şener, S. Ö., Korkmaz, N., Kalaycioglu, A. T., Öztürk, E., Sayım, A. Ü., et al. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202401366 · Cited by 4
The Extracellular Matrix Protein 1 (ECM1) in Molecular-Based Skin Biology
Oyama, N., & Merregaert, J. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_8-2 · Cited by 4
Lim, H. G., Kang, S., & Chien, A. L.-L. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788015981-00031 · Cited by 4
Kumar, A. V., Garg, V. K., Buttar, H. S., Choudhary, S., Sharma, S., & Grover, A. (2024) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-55474-2_6 · Cited by 4
Di, F., Cheng, W., Li, L., Pu, C., Sun, R., Zhang, J., Wang, C., & Li, M. (2024) · Fermentation · doi:10.3390/fermentation10060292 · Cited by 4
Lee, S., Shin, S., Jung, E., & Park, D. (2015) · Cytotechnology · doi:10.1007/s10616-015-9907-4 · Cited by 4
The Baumann Skin-Type Indicator
Baumann, L. (2009) · CRC Press eBooks · doi:10.1201/b15273-5 · Cited by 4
Moon, H., Kim, M.-R., Cho, M. K., Park, S., & Chung, J. (2005) · Phytotherapy Research · doi:10.1002/ptr.1682 · Cited by 4
RetractedThe Interface of Cosmetic Medicine and Surgery: Working from the Inside and the Outside
Markarian, M. K., & Hovsepian, R. V. (2011) · Clinics in Plastic Surgery · doi:10.1016/j.cps.2011.02.001 · Cited by 4
Weedon, D. D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-7020-3485-5.00013-9 · Cited by 4
Zhang, G., Wang, P., & Wang, X. (2017) · InTech eBooks · doi:10.5772/intechopen.70266 · Cited by 4
Lee, M. K., Joo, H., Bae, M., Lee, Y., Noh, J. K., Lee, Y. C., Lee, J. W., Min, S., Kong, M., Ko, S., et al. (2026) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00855-y · Cited by 3
Poly-L-Lactic Acid Filler Increases Adipogenesis and Adiponectin in Aged Subcutaneous Tissue
Oh, S., Shin, N., Lee, S. J., Son, K. H., & Byun, K. (2025) · Polymers · doi:10.3390/polym17131826 · Cited by 4
Jusuf, N. K., Bachtiar, A., Hadisahputra, S., & Soebono, H. (2014) · Journal of Biology Agriculture and Healthcare · Cited by 3
Herbal Detoxifiers: An Eminent Need of Today
Pal, R. S., Pal, Y., Wal, A., & Wal, P. (2019) · Current Nutrition & Food Science · doi:10.2174/1573401315666190311153200 · Cited by 3
Aguirre, A., Gil-Quintana, E., & Nuez, M. L. (2018) · Journal of Clinical Research in Dermatology · doi:10.15226/2378-1726/5/2/00180 · Cited by 3
Jia, Q., & Nash, J. F. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_28 · Cited by 3
The aging epidermal skin niche
Zhuang, L., & Kaur, P. (2020) · Advances in stem cells and their niches · doi:10.1016/bs.asn.2020.06.002 · Cited by 4
The Baumann Skin Typing System
Baumann, L. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_88 · Cited by 4
Skin Aging: A Brief Summary of Characteristic Changes
Wiegand, C., Raschke, C., & Elsner, P. U. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_5-2 · Cited by 3
Cosmeceutical Treatment of the Aging Face
Linder, J. (2011) · Springer eBooks · doi:10.1007/978-3-642-20113-4_8 · Cited by 3
Vieillissement cutané photo-induit
Leccia, M. ‐. (2006) · EMC - Cosmétologie et dermatologie esthétique · doi:10.1016/s1283-0143(06)41913-0 · Cited by 3
Oddos, T., Roure, R., Leyden, J., Bruère, V., & Bertin, C. (2012) · Journal of Cosmetics Dermatological Sciences and Applications · doi:10.4236/jcdsa.2012.22012 · Cited by 3
A Quantitative Approach to Age and Skin Structure and Function
Waller, J. M. (2009) · CRC Press eBooks · doi:10.1201/b15273-24 · Cited by 3
Bakuchiol: A Retinol-Like Functional Compound, Modulating Multiple Retinol and Non-Retinol Targets
Chaudhuri, R. K. (2015) · CRC Press eBooks · doi:10.1201/b18895-4 · Cited by 3
Determinants in the Rate of Skin Aging: Ethnicity, Gender, and Lifestyle Influences
Farage, M. A., Miller, K. W., & Maïbach, H. I. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_92 · Cited by 3
Mengungkap Potensi Kluwak (Pangium edule Reinw) Sebagai Antioksidan Alami dan Penghambat Senescence
Wardani, R. K., Putri, Y. M., Nurjanah, D. A., & Susidarti, R. A. (2021) · JURNAL ILMU KEFARMASIAN INDONESIA · doi:10.35814/jifi.v19i2.958 · Cited by 3
Collagen fiber and cellular dynamics of axolotl skin with aging
Shima, C., Ohashi, A., Furukawa, S., Yamamoto, S., Kashimoto, R., & Satoh, A. (2025) · Development Growth & Differentiation · doi:10.1111/dgd.70005 · Cited by 2
Metadata
- Authors
- Varani, J., Warner, R. L., Gharaee-Kermani, M., Phan, S. H., Kang, S., Chung, J., Wang, Z., Datta, S. C., Fisher, G. J., & Voorhees, J. J.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Varani, James
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 114
- Issue
- 3
- Pages
- 480-486
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2077292033
- Cited by
- 643
- References
- 47
- Citations by year
- 2026: 19 · 2025: 30 · 2024: 25 · 2023: 24 · 2022: 22 · 2021: 27 · 2020: 17 · 2019: 29 · 2018: 18 · 2017: 31 · 2016: 35 · 2015: 34 · 2014: 27 · 2013: 25 · 2012: 22
- FWCI
- 15.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- photoaging, vitamin A, retinol, matrix metalloproteinases, collagen synthesis, collagen deposition, fibroblast proliferation, connective tissue damage, sun-protected skin, oxidative stress
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Cell Division, Collagen, Connective Tissue, Fibroblasts, Humans, Middle Aged, Procollagen, Skin, Stimulation, Chemical, Vitamin A, Skin Aging, Matrix Metalloproteinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
