The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Long-term evolution of cardiomyopathy in dialysis patients
Open accessAbstract
Background Left ventricular enlargement is very common at the inception of dialysis therapy, and highly predictive of future cardiac morbidity and mortality. It is not known whether cardiac size increases further while on dialysis therapy and whether potentially reversible risk factors for later progression can be identified. METHODS; Baseline and yearly echocardiograms were performed in a prospective inception cohort of 433 dialysis patients. The mean patient follow-up was 41 months; 29 patients had four consecutive echocardiograms at yearly intervals.Results The patient subset with four echocardiograms was older (58 vs. 51 years, P = 0.02) and had a lower mass ventricular mass index (128 vs. 149 g/m2, P = 0.02) than the parent group. Using repeated measures analysis of variance, applied to those with four echocardiograms, there were progressive increases over time in posterior wall thickness (P = 0.015), left ventricular end-diastolic diameter, left ventricular mass index (P = 0.001), and cavity volume index (P = 0. 001). Mass-to-volume ratios did not change. The biggest changes in mass (18 g/m2 - 14%)and volume index (13 ml/m2 - 18%) occurred between baseline and year 1, although increases in both were seen after year 1. Hemodialysis versus peritoneal dialysis (41 g/m2, P = 0.008) and anemia (10 g/m2 per 1 g/dl drop in hemoglobin, P = 0.02) were associated with progressive left ventricular enlargement, but only within the first year of dialysis therapy. The left ventricular enlargement seen after year 1 was independent of anemia, blood pressure, serum albumin and mode of dialysis.Conclusions Progressive cardiac enlargement, particularly left ventricular dilation with compensatory hypertrophy, continues after starting dialysis therapy. Most of the additional cardiac enlargement seems to occur in the first year of dialysis therapy, suggesting that intervention beyond one year may be relatively ineffective.
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Metadata
- Authors
- Foley, R. N., Parfrey, P. S., Kent, G. M., Harnett, J. D., Murray, D. C., & Barre, P. E.
- Affiliations
- Memorial University of Newfoundland (CA)
- Corresponding author
- Foley, Robert N.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 54
- Issue
- 5
- Pages
- 1720-1725
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2130476101
- Cited by
- 226
- References
- 39
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 9 · 2015: 15 · 2014: 2 · 2013: 3 · 2012: 13
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Memorial University of Newfoundland
- Topics
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- left ventricular hypertrophy, left ventricular dilatation, dialysis patients, hemodialysis, peritoneal dialysis, anemia, left ventricular mass index, left ventricular end-diastolic diameter, cardiac remodeling, echocardiography
- MeSH terms
- Blood Pressure, Echocardiography, Renal Dialysis, Humans, Middle Aged, Prospective Studies, Hypertrophy, Left Ventricular
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