The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Anti-inflammatory and immunomodulatory effects of statins
Open accessAbstract
Anti-inflammatory and immunomodulatory effects of statins. 3-Hydroxy-3-methyl-gutaryl coenzyme A (HMG-CoA) reductase inhibitors or statins constitute the most powerful class of lipid-lowering drugs. Clinical trials have demonstrated a marked reduction in cardiovascular mortality in patients treated with statins. However, the benefits observed with statin therapy appear to be related, at least in part, with their cholesterol-lowering independent effects. Extensive research carried out mainly in the last decade suggests that the clinical benefits of these drugs could be related to an improvement in endothelial dysfunction, a reduction in blood thrombogenicity, anti-inflammatory properties, and, recently, immunomodulatory actions. In this sense, statins decrease T cell activation, the recruitment of monocytes and T cells into the arterial wall, and enhance the stability of atherosclerotic lesions. Many of these effects are related with the inhibition of isoprenoid synthesis, which serve as a lipid attachment for a variety of proteins implicated in intracellular signaling. In fact, small G proteins, whose proper membrane localization and function are dependent on isoprenylation, may play an important role in the lipid-lowering independent effects of HMG-CoA reductase inhibitors. This article summarizes the anti-inflammatory and immunomodulatory effects of statins and their participation in the different steps of atherosclerotic lesion formation.
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Cited by
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INFLAMMATION AND ATHEROSCLEROSIS
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Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
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Metadata
- Authors
- Blanco-Colio, L. M., Tuñón, J., Martín-Ventura, J. L., & Egido, J.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 63
- Issue
- 1
- Pages
- 12-23
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W1989797372
- Cited by
- 347
- References
- 133
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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