Apolipoprotein E in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis
Open accessAbstract
Background Hyperlipemia characterizes nephrotic syndrome (NS) and contributes to the progression of the underlying nephropathy. The data in the literature support an implication of apolipoprotein E (apoE) in both hyperlipemia and focal segmental glomerulosclerosis (FSGS), a malignant condition associated with NS. Methods The apoE genotype was determined in 209 nephrotic patients, who were classified according to age and their response to steroids as resistant children (N = 96) and adults (43), and steroid dependent (33) and steroid responder (37) children. A total of 123 presented the histological features of FSGS. In a subgroup of 28 patients, serum and urinary levels of apoE and renal deposits were evaluated by immunofluorescence. Results The allelic frequencies of the three major haplotypes epsilon2, epsilon3, and epsilon4 were the same in nephrotic patients versus controls, and homozygosity for epsilon3epsilon3 was comparably the most frequent genotype (70 vs. 71%) followed by epsilon3epsilon4, epsilon2epsilon3, epsilon2epsilon4, epsilon4epsilon4. Serum levels of apoE were fivefold higher in NS and in FSGS patients than in controls, with a direct correlation with hypercholesterolemia and proteinuria. ApoE genotypes did not influence serum levels. Urinary levels were 1/10,000 of serum with an increment in nephrotic urines. Finally, immunofluorescence demonstrated the absence of apoE in sclerotic glomeruli, while comparably nephrotic patients with membranous nephropathy had…
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Serum apoE concentration can be markedly elevated in nephrotic syndrome.
“Meanwhile, the serum concentration of apoE can be markedly elevated in nephrotic syndrome [12].”
Dyslipidemia and apoE abnormalities influence the foamy change of macrophages and mesangial cells.
“With respect to the onset of FSGS, dyslipidemia [7] and apoE abnormalities [8] also influence the foamy change of macrophages and mesangial cells”
From Focal segmental glomerulosclerosis with heterozygous apolipoprotein E5 (Glu3Lys) (2018) · cites this paper as [8]
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Weisgraber, K. H. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42621-5 · Cited by 304 · see citing works
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Dyslipidemia and nephrotic syndrome: recent advances.
Kronenberg, F. (2005) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2004.10.003 · Cited by 85 · see citing works
Focal segmental glomerulosclerosis with heterozygous apolipoprotein E5 (Glu3Lys)
Sasaki, M., Yasuno, T., Ito, K., Matsunaga, A., Hisano, S., Abe, Y., Miyake, K., Masutani, K., Nakashima, H., & Saito, T. (2018) · CEN Case Reports · doi:10.1007/s13730-018-0331-4 · Cited by 9 · see citing works
Koshino, A., Takaeda, C., Matsuno, T., Kitajima, S., Iwata, Y., Sakai, N., Nagahama, K., Niida, Y., Saito, T., Yokoyama, H., et al. (2022) · Case Reports in Nephrology and Dialysis · doi:10.1159/000525086 · Cited by 2 · see citing works
- Authors
- Bruschi, M., Catarsi, P., Candiano, G., Rastaldi, M. P., Musante, L., Scolari, F., Artero, M., Carraro, M., Carrea, A., Caridi, G., Zennaro, C., Sanna-Cherchi, S., Viola, F. B., Ferrario, F., Perfumo, F., & Ghiggeri, G. M.
- Affiliations
- Istituto Giannina Gaslini (IT)
- Corresponding author
- Ghiggeri, Gian Marco
- ORCID
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 63
- Issue
- 2
- Pages
- 686-695
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W1991473040
- Cited by
- 25
- References
- 1
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (other-oa)
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Keywords
- apolipoprotein E, idiopathic nephrotic syndrome, focal segmental glomerulosclerosis, hyperlipidemia, hypercholesterolemia, proteinuria, APOE genotype, membranous nephropathy, steroid resistance, lipid metabolism
- MeSH terms
- Adolescent, Adult, Apolipoproteins E, Child, Child, Preschool, Female, Genotype, Glomerulosclerosis, Focal Segmental, Humans, Kidney, Male, Nephrotic Syndrome, Cohort Studies
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