Biochemical analysis of acute and chronic wound environments
Abstract
The process of wound healing involves a complex interaction between numerous cell types, extracellular matrix molecules, and soluble mediators including growth factors and cytokines. This complex milieu is under active investigation for the purposes of beginning to understand how this environment regulates tissue repair. Quantitation of growth factors, cytokines, and matrix metalloproteinases within surgical wound fluids may help to elucidate this regulatory network, not only in noncomplicated wound healing but also in pathologic lesions such as chronic ulcers.
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IL-1β and TNFα are increased in chronic wounds, and this increase leads to elevated metalloproteinases that excessively degrade the local extracellular matrix and impair cell migration.
“IL-1β and TNFα are increased in chronic wounds, and this increase has been shown to lead to elevated metalloproteinases that excessively degrade the local ECM and thus impair cell migration (30).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [30]
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Cited by 372
- Authors
- Tarnuzzer, R. W., & Schultz, G. S.
- Affiliations
- University of Florida (US)
- Corresponding author
- Schultz, Gregory S.
- ORCID
- Tarnuzzer, Roy W.
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 1996-07
- Volume
- 4
- Issue
- 3
- Pages
- 321-325
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W2056706192
- Cited by
- 372
- References
- 0
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 15 · 2023: 9 · 2022: 26 · 2021: 14 · 2020: 10 · 2019: 19 · 2018: 21 · 2017: 17 · 2016: 20 · 2015: 16 · 2014: 17 · 2013: 17 · 2012: 15
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Wound Repair and Regeneration (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- wound healing, chronic wounds, chronic ulcers, growth factors, cytokines, matrix metalloproteinases, extracellular matrix, tissue repair
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