The DOI matches its Crossref record.
Interactions of cytokines, growth factors, and proteases in acute and chronic wounds
Abstract
A healing wound represents a complex series of interactions between cells, soluble mediators, and extracellular matrix. Within this multifaceted environment, there are multiple regulatory points which control the ordered series of events that lead to normal tissue repair. An alteration in this physiologic network can lead to the development of a chronic wound. This article presents an update on the numerous mediators that exist within the wound environment in both acute normal healing and chronic nonhealing wounds. We also present a hypothesis which may provide a conceptual pathophysiologic mechanism with which to understand all chronic wounds.
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In the citing paper
“Elevated levels of IL-1β have been found in wounds of diabetic humans and mice (12,15,19,20)”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [19]
In the citing paper
“Chronic wounds are typically associated with a persistent inflammatory response that involves accumulation of Mp (19,26–28)”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [19]
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PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing
Barrientos, S., Stojadinovic, O., Golinko, M. S., Brem, H., & Tomic‐Canic, M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00410.x · Cited by 3,583
“It has been shown that PDGF is susceptible to the proteolytic environment found in the chronic wound and its degradation can be reversed with the addition of MMP inhibitors.(51) It is the increased MMP activity that degrades the ECM inhibiting cell migration and collagen deposition.”
BackgroundInfluentialWound bed preparation: a systematic approach to wound management
Schultz, G. S., Sibbald, R. G., Falanga, V., Ayello, E. A., Dowsett, C., Harding, K. G., Romanelli, M., Stacey, M. C., Téot, L., & Vanscheidt, W. (2003) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.11.s2.1.x · Cited by 1,440
“There is often a pro-inflammatory stimulus due to necrotic tissue, a heavy bacterial burden, and tissue breakdown that causes cellular and biochemical changes in the wound bed such as increased levels of MMPs, which degrade the ECM and result in impaired cell migration and deposition of connective tissue.(29) MMPs als…”
BackgroundSelf-citationInflammation in Chronic Wounds
Zhao, R., Liang, H. H., Clarke, E., Jackson, C., & Xue, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122085 · Cited by 1,250
“Both neutrophils and activated macrophages also produce pro-inflammatory cytokines such as IL-1β and TNF-α that not only increase MMP production but also reduce tissue inhibitors of MMPs (TIMPs); this imbalance augments degradation of the ECM, impairs cell migration, and reduces fibroblast proliferation and collagen s…”
BackgroundDiabetic Wound-Healing Science
Burgess, J. L., Wyant, W. A., Abujamra, B. A., Kirsner, R. S., & Jozic, I. (2021) · Medicina · doi:10.3390/medicina57101072 · Cited by 1,024
“Moreover, DFUs often exhibit deregulation and mislocalization of GF receptors [227–229], as well compartmentalization within microdomains (i.e., cave-olae), which prevent activation of downstream signaling events [230–232].”
BackgroundOxygen in acute and chronic wound healing
Schreml, S., Szeimies, R., Prantl, L., Karrer, S., Landthaler, M., & Babilas, P. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09804.x · Cited by 817
Metadata
- Authors
- Mast, B. A., & Schultz, G. S.
- Affiliations
- University of Florida Health (US)
- University of Florida (US)
- Corresponding author
- Mast, Bruce A.
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 1996-10
- Volume
- 4
- Issue
- 4
- Pages
- 411-420
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W1970955409
- Cited by
- 598
- References
- 0
- Citations by year
- 2026: 14 · 2025: 25 · 2024: 26 · 2023: 23 · 2022: 23 · 2021: 37 · 2020: 32 · 2019: 31 · 2018: 39 · 2017: 24 · 2016: 25 · 2015: 24 · 2014: 24 · 2013: 33 · 2012: 30
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Wound Repair and Regeneration (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- chronic wounds, acute wound healing, cytokines, growth factors, proteolytic enzymes, extracellular matrix, tissue repair
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