Chemotherapy-evoked Painful Peripheral Neuropathy
Abstract
Vincristine and paclitaxel, two of the most effective drugs in the battle against cancer, produce a dose-limiting neurotoxicity that sometimes presents as a painful peripheral neuropathy. For the first time, investigators have been able to produce these chemotherapy-evoked painful peripheral neuropathies in the laboratory rat. These new models have already begun to elucidate the causes of the neuropathic pain associated with these antineoplastic drugs, which will now make it possible to search for effective ways to prevent and treat it.
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Lower doses of paclitaxel (eg, 0.5, 1, or 2 mg/kg, intraperitoneal) administered on alternate days for four injections elicit thermal and mechanical hyperalgesia as well as allodynia to light touch and cold stimuli.
“On the other hand, lower doses of paclitaxel (eg, 0.5, 1, or 2 mg/kg, intraperitoneal) administered on alternate days for four injections elicit thermal and mechanical hyperalgesia as well as allodynia to light touch and cold stimuli (Polomano and Bennett, 2001).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Polomano and Bennett, 2001
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References 51 · Cited by 100
- Authors
- Polomano, R. C., & Bennett, G. J.
- Affiliations
- Penn State Milton S. Hershey Medical Center (US)
- Hahnemann University Hospital (US)
- Corresponding author
- Polomano, Rosemary C.
- Venue
- Pain Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-03
- Volume
- 2
- Issue
- 1
- Pages
- 8-14
- ISSN
- 1526-2375 (ISSN-L)
- 1526-4637
- OpenAlex
- W2131762605
- Cited by
- 100
- References
- 51
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 7 · 2018: 1 · 2017: 7 · 2016: 3 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 8
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
- Keywords
- chemotherapy-induced peripheral neuropathy, peripheral neuropathic pain, vincristine, paclitaxel, neuropathic pain, rat model, neuropathic pain mechanisms
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