The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Role of Benzodiazepines in the Treatment of Insomnia: Meta‐Analysis of Benzodiazepine Use in the Treatment of Insomnia
Abstract
PURPOSE: To obtain a precise estimate of the efficacy and common adverse effects of benzodiazepines for the treatment of insomnia compared with those of placebo and other treatments. BACKGROUND: Insomnia, also referred to as disorder of initiating or maintaining sleep, is a common problem and its prevalence among older people is estimated to be 23% to 34%. The total direct cost in the United States for insomnia in 1995 was estimated to be $13.9 billion. The complaint of insomnia in older people is associated with chronic medical conditions; psychiatric problems, mainly depression, chronic pain, and poor perceived general condition; and use of sleep medications. Thus in most cases, insomnia is due to some other underlying problem and is not just a consequence of aging. Accordingly, the management of insomnia should focus on addressing the primary problem and not just short‐term treatment of the insomnia. Benzodiazepines belong to the drug class of choice for the symptomatic treatment of primary insomnia. This abstract will appraise a meta‐analysis that compared the effect of benzodiazepines for short‐term treatment of primary insomnia with placebo or other treatment. DATA SOURCES: Data sources included articles listed in Medline from 1966 to December 1998 and the Cochrane Controlled Trials Registry. The medical subject heading (MeSH) search terms used were “benzodiazepine” (exploded) or “benzodiazepine tranquillizers” (exploded) or “clonazepam,”“drug therapy,”“randomized contr…
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Each of the short/intermediate-acting BzRAs (zaleplon, zolpidem, eszopiclone, triazolam, temazepam) has been shown to have positive effects on sleep latency, TST, and/or WASO in placebo-controlled trials.
“each has been shown to have posi -tive effects on sleep latency, TST, and/or WASO in placebocontrolled trials. 32-37”
From Clinical Guideline for the Evaluation and Management of Chronic Insomnia in Adults (2008) · cites this paper as [33]
Citations
Cites
Behavioral and Pharmacological Therapies for Late-Life Insomnia: A Randomized Controlled Trial
Morin, C. M., Colecchi, C., Stone, J., Sood, R., & Brink, D. (1999) · JAMA · doi:10.1001/jama.281.11.991 · Cited by 1,095
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Clinical Guideline for the Evaluation and Management of Chronic Insomnia in Adults
Schutte-Rodin, S., Broch, L., Buysse, D., Dorsey, C., & Sateia, M. (2008) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27286 · Cited by 1,943
Sivertsen, B., Omvik, S., Pallesen, S., Bjorvatn, B., Havik, O. E., Kvale, G., Nielsen, G. H., & Nordhus, I. H. (2006) · JAMA · doi:10.1001/jama.295.24.2851 · Cited by 589
On the comparability of pharmacotherapy and behavior therapy for chronic insomnia
Perlis, M. L., Smith, M. T., Cacialli, D. O., Nowakowski, S., & Orff, H. (2003) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00547-0 · Cited by 36
Metadata
- Authors
- Holbrook, A., Crowther, R., Lotter, A., & Endeshaw, Y.
- Affiliations
- Emory University (US)
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2001-06
- Volume
- 49
- Issue
- 6
- Pages
- 824-826
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W1496236398
- Cited by
- 61
- References
- 1
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 3 · 2022: 6 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Keywords
- benzodiazepines, insomnia, primary insomnia, sleep latency, total sleep time, adverse effects, older adults, clonazepam, placebo comparison, drug efficacy, chronic pain, chronic disease, daytime functioning, falls in older adults
- MeSH terms
- Age Factors, Aged, Benzodiazepines, Female, Humans, Sleep Initiation and Maintenance Disorders, Male, Research Design, Sleep Stages, Time Factors, Anti-Anxiety Agents, United States, Prevalence, Randomized Controlled Trials as Topic, Drug Costs, Treatment Outcome, Health Care Costs, Age Distribution, Patient Selection, Evidence-Based Medicine
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