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Evidence of Specialized Conduction Cells in Human Pulmonary Veins of Patients with Atrial Fibrillation
Open accessAbstract
Introduction: Depolarizations similar to those from the sinus node have been documented from the pulmonary veins after isolation procedures. We assessed the hypothesis that sinus node‐like tissue is present in the pulmonary veins of humans. Methods and Results: Pulmonary vein tissue was obtained from five autopsies (four individuals with a history of atrial fibrillation and one without a history of atrial arrhythmias) and five transplant heart donors. Autopsy veins were fixed in formaldehyde and processed for light microscopy to identify areas having possible conductive‐like tissue. Areas requiring additional study were extracted from paraffin blocks and reprocessed for electron microscopy. Donor specimens were fixed in formaldehyde for histologic sections and glutaraldehyde for electron microscopy. Myocardial cells with pale cytoplasm were identified by light microscopy in 4 of the 5 autopsy subjects. Electron microscopy confirmed the presence of P cells, transitional cells, and Purkinje cells in the pulmonary veins of these cases. Conclusion: Our report is the first to show the presence of P cells, transitional cells, and Purkinje cells in human pulmonary veins. Whether these cells are relevant in the genesis of atrial fibrillation requires further study. (J Cardiovasc Electrophysiol, Vol. 14, pp. 803‐809, August 2003)
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Cited by
Calkins, H., Hindricks, G., Cappato, R., Kim, Y.-H., Saad, E. B., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, J., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.05.012 · Cited by 2,755
Self-citationCalkins, H., Kuck, K. H., Cappato, R., Brugada, J., Camm, A. J., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., DiMarco, J., et al. (2012) · Europace · doi:10.1093/europace/eus027 · Cited by 2,722
Self-citationCalkins, H., Kuck, K. H., Cappato, R., Brugada, J., Camm, A. J., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., DiMarco, J., et al. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2011.12.016 · Cited by 1,456
Self-citationPathophysiological mechanisms of atrial fibrillation: a translational appraisal
Schotten, U., Verheule, S., Kirchhof, P., & Goette, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2009 · Cited by 1,273
Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics
Shivkumar, K., Ajijola, O. A., Anand, I., Armour, J. A., Chen, P., Esler, M., De Ferrari, G. M., Fishbein, M. C., Goldberger, J. J., Harper, R. M., et al. (2016) · The Journal of Physiology · doi:10.1113/jp271870 · Cited by 308
Metadata
- Authors
- Perez‐Lugones, A., McMahon, J. T., Ratliff, N. B., Saliba, W. I., Schweikert, R. A., Marrouche, N. F., Saad, E. B., Navia, J. L., McCarthy, P. M., Tchou, P., Gillinov, A. M., & Natale, A.
- Venue
- Journal of Cardiovascular Electrophysiology
- Publisher
- Wiley
- Published
- 2003-07-22
- Volume
- 14
- Issue
- 8
- Pages
- 803-809
- ISSN
- 1045-3873 (ISSN-L)
- 1540-8167
- OpenAlex
- W2103064390
- Cited by
- 200
- References
- 0
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Perez‐Lugones, A., McMahon, J. T., Ratliff, N. B., Saliba, W. I., Schweikert, R. A., Marrouche, N. F., Saad, E. B., Navia, J. L., McCarthy, P. M., Tchou, P., Gillinov, A. M., & Natale, A. (2003). Evidence of Specialized Conduction Cells in Human Pulmonary Veins of Patients with Atrial Fibrillation. Journal of Cardiovascular Electrophysiology. https://doi.org/10.1046/j.1540-8167.2003.03075.x
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