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Cited by 580

The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.

Platelet-Rich Plasma and Platelet Gel: A Review

Open access
Everts, Peter A.M., Knape, Johannes T.A., Weibrich, Gernot, Schönberger, Jacques P.A.M., Hoffmann, Johannes, Overdevest, Eddy P., Box, Henk A.M., van Zundert, André·2006·The Journal of ExtraCorporeal Technology

Abstract

Strategies to reduce blood loss and transfusion of allogeneic blood products during surgical procedures are important in modern times. The most important and well-known autologous techniques are preoperative autologous predonation, hemodilution, perioperative red cell salvage, postoperative wound blood autotransfusion, and pharmacologic modulation of the hemostatic process. At present, new developments in the preparation of preoperative autologous blood component therapy by whole blood platelet-rich plasma (PRP) and platelet-poor plasma (PPP) sequestration have evolved. This technique has been proven to reduce the number of allogeneic blood transfusions during open heart surgery and orthopedic operations. Moreover, platelet gel and fibrin sealant derived from PRP and PPP mixed with thrombin, respectively, can be exogenously applied to tissues to promote wound healing, bone growth, and tissue sealing. However, to our disappointment, not many well-designed scientific studies are available, and many anecdotic stories exist, whereas questions remain to be answered. We therefore decided to study perioperative blood management in more detail with emphasis on the application and production of autologous platelet gel and the use of fibrin sealant. This review addresses a large variety of aspects relevant to platelets, platelet-rich plasma, and the application of platelet gel. In addition, an overview of recent animal and human studies is presented.

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Crossref · 10.1051/ject/200638174

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Metadata

Authors
Everts, P. A. M., Knape, J. T. A., Weibrich, G., Schönberger, J. P. A. M., Hoffmann, J., Overdevest, E. P., Box, H. A. M., & van Zundert, A.
Venue
The Journal of ExtraCorporeal Technology
Publisher
EDP Sciences
Published
2006-06
Volume
38
Issue
2
Pages
174-187
ISSN
  • 0022-1058 (ISSN-L)
  • 2969-8960
OpenAlex
W2099229475
Cited by
580
References
88
FWCI
8.86
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Platelet-Rich Plasma and Platelet Gel: A Review. https://app.cochat.ai/papers/10.1051/ject/200638174
The paper
Everts, P. A. M., Knape, J. T. A., Weibrich, G., Schönberger, J. P. A. M., Hoffmann, J., Overdevest, E. P., Box, H. A. M., & van Zundert, A. (2006). Platelet-Rich Plasma and Platelet Gel: A Review. The Journal of ExtraCorporeal Technology. https://doi.org/10.1051/ject/200638174

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.