Efficacy of Olyset ® Duo, a permethrin and pyriproxyfen mixture net against wild pyrethroid-resistant Anopheles gambiae s.s. from Côte d’Ivoire: an experimental hut trial
Open accessAbstract
Pyrethroid resistance in malaria vectors has spread across sub-Saharan Africa. Alternative tools and molecules are urgently needed for effective vector control. One of the most promising strategies to prevent or delay the development of resistance is to use at least two molecules having unrelated modes of action in combination in the same bed net. We evaluated in experimental huts in Côte d'Ivoire, a new polyethylene long-lasting insecticidal net (LN) product, Olyset® Duo, incorporating permethrin (PER) and pyriproxyfen (PPF), an insect growth regulator (IGR). PPF alone or in combination with permethrin had a significant impact on fertility (7-12% reduction relative to control) and no effect on fecundity of wild multi-resistant An. gambiae s.s. These results triggered crucial research questions on the behaviour of targeted mosquitoes around the LN. To maximize the sterilizing effect of PPF in the combination, there would be a need for a trade-off between the necessary contact time of the insect with PPF and the surface content of the pyrethroid insecticide that is bioavailable and induces excito-repellency.
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The experimental period from 20.00 to 05.00 is representative of the period when household members are likely to be indoors and is typical for experimental hut studies.
“(the experimental period from 20.00 to 05.00 is representative of the period when household members are likely to be indoors and is typical for experimental hut studies [9, 10])”
From Semi-field studies to better understand the impact of eave tubes on mosquito mortality and behaviour (2018) · cites this paper as [10]
The Materials and methods section (Experimental hut trial; page unavailable) says volunteers entered the huts at dusk and slept until dawn, supporting an overnight experimental-hut period. It does not specify 20.00–05.00, establish when household members are likely to be indoors, or say those hours are typical of experimental hut studies. (LLM, conf=0.82)
Experimental — accuracy not yet measuredThe Anopheles gambiae species complex is the dominant species, with A funestus and A nili also present.
“The Anopheles gambiae species complex is the dominant species, with A funestus and A nili also present.26”
From Impact and cost-effectiveness of a lethal house lure against malaria transmission in central Côte d'Ivoire: a two-arm, cluster-randomised controlled trial (2021) · cites this paper as [26]
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References 24 · Cited by 45
Research works printed but not linked: 1
- [25]WHO. 2001 Report of the fifth WHOPES working group meeting. Review of Olyset Net, Bifenthrin 10% WP. World Health Organization: Geneva.
- Authors
- Koffi, A. A., Ahoua Alou, L. P., Djenontin, A., Kabran, J.-P. K., Dosso, Y., Kone, A., Moiroux, N., & Pennetier, C.
- Affiliations
- Institut National de Santé Publique (CI)
- Centre National de la Recherche Scientifique (FR)
- Venue
- Parasite
- Publisher
- EDP Sciences
- Published
- 2015
- Volume
- 22
- Pages
- 28
- ISSN
- 1252-607X (ISSN-L)
- 1776-1042
- PMC
- PMC4613874
- OpenAlex
- W2148318054
- Cited by
- 45
- References
- 24
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 14 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 2
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Parasite (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, public-domain)
- Greater South Information System
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
- Keywords
- permethrin, pyriproxyfen, insect growth regulators, long-lasting insecticidal nets, Anopheles gambiae s.s., pyrethroid resistance, malaria vector control, insect fertility, fecundity, experimental hut trials, excito-repellency, Côte d'Ivoire
- MeSH terms
- Animals, Anopheles, Drug Synergism, Equipment Failure, Feeding Behavior, Female, Fertility, Housing, Insect Vectors, Insecticide Resistance, Cote d'Ivoire, Malaria, Mosquito Control, Pyridines, Insect Proteins, Permethrin, Clutch Size, Insecticide-Treated Bednets, Voltage-Gated Sodium Channels
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