Gross motor function of children with down syndrome: creation of motor growth curves.
Abstract
Objective To create gross motor function growth curves for children with Down syndrome (DS) and to estimate the probability that motor functions are achieved by different ages. Design Nonlinear growth curve analysis by using a 2-parameter (rate, upper limit) model. Setting Early intervention programs, schools, and children's homes. Participants One hundred twenty-one children with DS, ages 1 month to 6 years. Main outcome measures Gross Motor Function Measure (GMFM) and severity of motor impairment. Results The curves for children with mild (n = 51) and moderate/severe (n = 70) impairment were characterized by a greater increase in GMFM scores during infancy and smaller increases as the children approached the predicted maximum score of 85.9 or 87.9. The estimated probability that a child would roll by 6 months was 51%; sit by 12 months, 78%; crawl by 18 months, 34%; walk by 24 months, 40%; and run, walk up stairs, and jump by 5 years, 45% to 52%. Conclusions Children with DS require more time to learn movements as movement complexity increases. Impairment severity affected the rate but not the upper limit of motor function. The results have implications for counseling parents, making decisions about motor interventions, and anticipating the time frame for achievement of motor functions.
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Motor deficits are present at birth in Down syndrome, indicating that changes in cellular circuitry of the spinal cord likely precede adulthood.
“However, motor deficits are present at birth indicating that changes in cellular circuitry of the spinal cord likely precede adulthood.”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Palisano et al., 2001
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Evidence based medicine: what it is and what it isn't
Sackett, D. L., Rosenberg, W. M. C., Gray, J. A. M., Haynes, R. B., & Richardson, W. S. (1996) · BMJ · doi:10.1136/bmj.312.7023.71 · Cited by 15,769 · see citing works
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Neurodevelopment in Down syndrome: Concordance in humans and models
Klein, J. A., & Haydar, T. F. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.941855 · Cited by 47 · see citing works
“While the majority of studies have focused heavily on identifying perturbations in brain development in DS, there are also alterations in the cellular composition of the spinal cord that are thought to contribute to the motor deficits found in DS (Morris et al., 1982; Palisano et al., 2001).”
Background
- Authors
- Palisano, R. J., Walter, S. D., Russell, D. J., Rosenbaum, P. L., Gémus, M., Galuppi, B. E., & Cunningham, L.
- Affiliations
- CanChild Centre for Childhood-onset Disability Research (CA)
- Venue
- Archives of Physical Medicine and Rehabilitation
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 82
- Issue
- 4
- Pages
- 494-500
- ISSN
- 0003-9993 (ISSN-L)
- OpenAlex
- W2152508103
- Cited by
- 288
- References
- 1
- Citations by year
- 2026: 14 · 2025: 8 · 2024: 22 · 2023: 16 · 2022: 18 · 2021: 26 · 2020: 16 · 2019: 14 · 2018: 13 · 2017: 23 · 2016: 16 · 2015: 14 · 2014: 11 · 2013: 10 · 2012: 10
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Physical Medicine and Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Social Sciences › Psychology › Developmental and Educational Psychology › Children's Physical and Motor Development
- Health Sciences › Medicine › Psychiatry and Mental health › Cerebral Palsy and Movement Disorders
- Keywords
- Down syndrome, gross motor function, motor development, Gross Motor Function Measure, motor impairment severity, motor milestones, early intervention
- MeSH terms
- Child, Child, Preschool, Down Syndrome, Female, Humans, Infant, Male, Motor Skills, Probability, Prospective Studies, Reference Values, Regression Analysis
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