Nitric Oxide: Implications for Vascular and Endovascular Surgery
Open accessAbstract
Nitric oxide has a key role in vascular homeostasis. It plays a protective role by suppressing abnormal proliferation of vascular smooth muscle following various pathological situations including atherosclerosis and restenosis after vascular interventions such as balloon angioplasty, stent deployment and bypass grafting. It also has strong antiplatelet and anti-thrombogenic properties. In this review, possible applications to daily vascular and endovascular surgery practice, including systemic use of NO donors, enhancing endogenous production of NO by L-arginine and gene therapy, local delivery strategies and coating stents and grafts with NO-delivering/enhancing chemicals are reviewed.
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The human body synthesizes bio-regulatory NO from L-arginine via three NOS isoforms: eNOS, nNOS, and iNOS.
“The human body synthesizes a large quantity of bio-regulatory NO from the substrate L-arginine via three distinct isoforms of nitric oxide synthase (NOS), including endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS).118–120”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [119]
Surgery or trauma that destroys the endothelial lining and certain vascular diseases increase superoxide anions, which react with NO and reduce its bioavailability.
“Some surgery interventions or trauma that destroys the endothelial lining, as well as certain vascular diseases, will lead to an increased level of superoxide anions and that react with NO and reduce its bioavailablity.119,130”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [119]
iNOS is synthesized in the early phase of wound healing by inflammatory cells such as macrophages, monocytes, and other immune lineage cells.
“The iNOS is synthesized in the early phase of wound healing by inflammatory cells, such as macrophages, monocytes, and other immune lineage cells.119,120,292”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [119]
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References 80 · Cited by 43
- Authors
- Vural, K. M., & Bayazit, M.
- Affiliations
- Türkiye Yüksek İhtisas Hastanesi (TR)
- ORCID
- Vural, K.M.
- Venue
- European Journal of Vascular and Endovascular Surgery
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 22
- Issue
- 4
- Pages
- 285-293
- ISSN
- 1078-5884 (ISSN-L)
- OpenAlex
- W1970333551
- Cited by
- 43
- References
- 80
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 9 · 2015: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- European Journal of Vascular and Endovascular Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- nitric oxide, vascular homeostasis, vascular smooth muscle cell proliferation, atherosclerosis, restenosis, balloon angioplasty, stent deployment, bypass grafting, antiplatelet activity, nitric oxide donors, L-arginine, gene therapy, stent coating
- MeSH terms
- Angioplasty, Balloon, Animals, Blood Vessel Prosthesis, Cell Division, Endothelium, Vascular, Homeostasis, Humans, Nitric Oxide, Recurrence, Thrombosis, Vascular Diseases, Vasomotor System, Stents, Nitric Oxide Donors
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