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Cited by 271Heart Failure Treatment and ManagementCardiovascular Function and Risk FactorsDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Glucose and insulin abnormalities relate to functional capacity in patients with congestive heart failure

Suskin, N·2000·European Heart Journal
DOI 10.1053/euhj.1999.2043
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Abstract

AIMS: In addition to diabetes mellitus, less severe abnormalities of glucose and insulin metabolism may be related to functional status in patients with heart failure. We examined the relationship of hyperglycaemia (> or =6.1 mmol. l(-1)) and hyperinsulinaemia (> or =11.2 mU. l(-1)) to functional status and cardiac function in patients with heart failure. METHODS AND RESULTS: Fasting plasma glucose and insulin levels were obtained in 663 heart failure patients. The average left ventricular ejection fraction was 0.28+/-0.07, 63% were in New York Heart Association Functional Class (NYHA-FC) I/II and 37% were in NYHA-FC III/IV. Twenty seven percent had diabetes mellitus, but an additional 8% had undiagnosed diabetes mellitus (glucose > or =7 mmol. l(-1)) and 9% had glucose levels between 6.1 and 7 mmol. l(-1), so that a total of 43% (287) of patients had elevated glucose levels (> or =6.1 mmol. l(-1)). In general, more diabetic patients had NYHA-FC III/IV symptoms, shorter 6 min walk distances, but similar left ventricular ejection fractions compared to non-diabetic patients. The non-diabetic patients in NYHA-FC III/IV had higher glucose and insulin levels than patients in NYHA-FC I/II (6.3+/-0.2 vs 5.6+/-0.1 mmol. l(-1), P<0.001 and 19.6+/-2.3 vs 10. 2+/-0.6 mU. l(-1), P<0.001). Non-diabetic patients with elevated glucose levels had shorter 6 min walk distances compared to those with normal glucose levels (368.2+/-8 m vs 389.+/-4 m, P=0.02), however, left ventricular ejection fraction was similar. CONCLUSION: Glucose abnormalities are extremely common in heart failure patients (43% of patients). Diabetes mellitus and hyperglycaemia or hyperlinsulinaemia in non-diabetic patients were related to worse symptomatic status but not worsening left ventricular ejection fraction compared to patients with normal glucose and insulin levels.

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Crossref · 10.1053/euhj.1999.2043

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Metadata

Authors
Suskin, N.
Affiliations
London Health Sciences Centre (CA)
Corresponding author
Suskin, N
ORCID
Suskin, N
Venue
European Heart Journal
Publisher
Oxford University Press (OUP)
Published
2000-08-15
Volume
21
Issue
16
Pages
1368-1375
ISSN
0195-668X (ISSN-L)
DOI
10.1053/euhj.1999.2043
OpenAlex
W2158721215
Cited by
271
References
28
Citations by year
2026: 2 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 6 · 2019: 18 · 2018: 7 · 2017: 7 · 2016: 11 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 18
FWCI
3.46
Type
journal article
Language
en
Open access
closed
Locations
  • European Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
congestive heart failure, hyperglycemia, hyperinsulinemia, glucose metabolism, insulin metabolism, functional capacity, NYHA functional class, 6-minute walk distance, left ventricular ejection fraction, diabetes mellitus, undiagnosed diabetes, cardiac function
MeSH terms
Blood Glucose, Diabetes Mellitus, Exercise Test, Female, Heart Failure, Humans, Hyperglycemia, Hyperinsulinism, Insulin, Insulin Resistance, Male, Middle Aged, Myocardial Contraction, Pilot Projects, Prognosis, Risk Factors, Stroke Volume, Cohort Studies, Biomarkers, Incidence, Ventricular Function, Left

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