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Better survival rates in patients with MLH1-associated hereditary colorectal cancer
Open accessAbstract
BACKGROUND & AIMS: Patients with hereditary nonpolyposis colorectal can cer (HNPCC) have been suggested to have a better prognosis than patients with common sporadic colorectal cancer. However, the evidence has not been convincing. The aim of this population-based study was to compare the survival rates of 175 patients with HNPCC with those of 14,000 patients with sporadic colorectal cancer diagnosed at <65 years of age in Finland from 1953 to 1993. METHODS: The recent progress in molecular genetics of hereditary colorectal cancer was utilized for the first time. One hundred twenty of the patients with HNPCC came from families segregating a germline mutation in the MLH1 cancer predisposition gene. RESULTS: The overall 5-year cumulative relative survival rate was 65% for patients with HNPCC and 44% for patients with sporadic colorectal cancer. The relative survival rates of patients with HNPCC were better in every strata analyzed. CONCLUSIONS: MLH1-associated colorectal cancer has a natural history different from that of common sporadic colorectal cancer. The better survival rates may be caused by the heavy mutation burden affecting mismatch repair deficient tumor cells.
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Cited by
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Boland, C. R., & Goel, A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.064 · Cited by 2,456
Cancer risk associated with germline DNA mismatch repair gene mutations
Dunlop, M. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.1.105 · Cited by 688
Lin, S.-M., Lin, C.-J., Lin, C.-C., Hsu, C.-W., & Chen, Y.-C. (2005) · Gut · doi:10.1136/gut.2004.045203 · Cited by 592
Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal carcinoma
Smyrk, T. C., Watson, P., Kaul, K., & Lynch, H. T. (2001) · Cancer · doi:10.1002/1097-0142(20010615)91:12<2417::aid-cncr1276>3.0.co;2-u · Cited by 522
Identification and Survival of Carriers of Mutations in DNA Mismatch-Repair Genes in Colon Cancer
Barnetson, R. A., Tenesa, A., Farrington, S. M., Nicholl, I. D., Cetnarskyj, R., Porteous, M. E., Campbell, H., & Dunlop, M. G. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa053493 · Cited by 477
Metadata
- Authors
- Sankila, R., Aaltonen, L., Jarvinen, H., & Mecklin, J.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1996-03
- Volume
- 110
- Issue
- 3
- Pages
- 682-687
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1986604538
- Cited by
- 354
- References
- 0
- FWCI
- 21.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sankila, R., Aaltonen, L., Jarvinen, H., & Mecklin, J. (1996). Better survival rates in patients with MLH1-associated hereditary colorectal cancer. Gastroenterology. https://doi.org/10.1053/gast.1996.v110.pm8608876
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