The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Long-term Risk of Mortality and Other Adverse Outcomes After Acute Kidney Injury: A Systematic Review and Meta-analysis
Open accessAbstract
Background Acute kidney injury (AKI) is common in hospitalized patients. The impact of AKI on long-term outcomes is controversial. Study Design Systematic review and meta-analysis. Setting & Participants Persons with AKI. Selection Criteria for Studies MEDLINE and EMBASE databases were searched from 1985 through October 2007. Original studies describing outcomes of AKI for patients who survived hospital discharge were included. Studies were excluded from review when participants were followed for < 6 months. Predictor AKI, as defined by acute changes in serum creatinine or acute need for renal replacement therapy. Outcomes CKD, cardiovascular disease, mortality. Results Forty nine studies that contained a total of 47,017 participants were reviewed. Fifteen of these studies reported long-term data for patients without AKI. The incidence rate of mortality was 8.9 per 100 person-years in survivors of AKI and was 4.3 per 100 patient-years in survivors without AKI (RR 2.59, 95% CI 1.97-3.42). AKI was associated independently with mortality risk in 6 of 6 studies that performed multivariate adjustment (adjusted RR 1.6-3.9) and it was associated with myocardial infarction in 2 of 2 studies (RR 2.05, 95% CI 1.61-2.61). The incidence rate of CKD after an episode of AKI was 7.8 per 100 patient years and the rate of ESRD was 4.9 per 100 patient-years. Limitations The relative risk for CKD and ESRD after AKI was unattainable due to lack of follow-up of appropriate non-AKI controls. Conclusions The development of AKI, as defined by acute changes in serum creatinine characterizes hospitalized patients at elevated risk of long-term adverse outcomes.
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Ronco, C., Bellomo, R., & Kellum, J. A. (2019) · The Lancet · doi:10.1016/s0140-6736(19)32563-2 · Cited by 1,910
Acute Kidney Injury Associates with Increased Long-Term Mortality
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Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease
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Metadata
- Authors
- Coca, S. G., Yusuf, B., Shlipak, M. G., Garg, A. X., & Parikh, C. R.
- Venue
- American Journal of Kidney Diseases
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 53
- Issue
- 6
- Pages
- 961-973
- ISSN
- 0272-6386 (ISSN-L)
- OpenAlex
- W2028701043
- Cited by
- 1,161
- References
- 55
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- green
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