The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Proton Pump Inhibitor Use and Risk of Colorectal Cancer: A Population-Based, Case–Control Study
Abstract
Background & aims Use of proton pump inhibitors (PPIs) has been associated with elevated levels of serum gastrin. Because hypergastrinemia increases colorectal mucosa proliferation and has been associated with risk of colorectal cancer (CRC) in human beings, we conducted a large population-based study in Denmark to assess whether PPI use is associated with CRC risk.Methods We conducted the study in North Jutland County, Denmark. From the County Hospital Discharge Registry we identified incident cases of CRC during the period 1989-2005. Using risk set sampling we selected approximately 10 controls from the Danish Civil Registration System, with matching for sex and birth year. PPI use was ascertained in the Prescription Database of North Jutland (and so recorded before CRC diagnosis) and analyzed with conditional logistic regression adjusted for multiple covariates.Results We identified 5589 cases of CRC which were compared with 55,890 controls. In a comparison of ever to never or rare users (< or =30 pills during observation period), no evidence was observed of increased risk (adjusted odds ratio [OR], 1.11; 95% confidence interval [CI], 0.97-1.27). When we compared the most intense users of PPI (more than every other day) with never or rare users, we found that no increased cancer risk was shown in either short-term users (adjusted OR, 1.07; 95% CI, 0.86-1.34) or long-term users (>7 years; adjusted OR = 1.09; 95% CI, 0.58-2.06).Conclusions The use of PPIs in clinical practice does not measurably increase the risk of CRC.
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“Nevertheless, it is fundamental to highlight that many studies over the years have not found a direct correlation between PPI use in clinical practice and an increased risk of CRC[154-156].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [156]
Citations
Cites
The Danish National Hospital Register. A valuable source of data for modern health sciences.
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Epidemiology: Beyond the Basics
Szklo, M. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.8.821 · Cited by 1,320
Long-term Proton Pump Inhibitor Therapy and Risk of Hip Fracture
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A Comparison of Five Maintenance Therapies for Reflux Esophagitis
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Freedberg, D. E., Kim, L. S., & Yang, Y. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.031 · Cited by 933
Control of Gastric Acid Secretion in Health and Disease
Schubert, M. L., & Peura, D. A. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.05.021 · Cited by 493
for the SIF-AIGO-FIMMG Group, Scarpignato, C., on behalf of the Italian Society of Pharmacology, T. I. A. O. H. G., Gatta, L., Zullo, A., & Blandizzi, C. (2016) · BMC Medicine · doi:10.1186/s12916-016-0718-z · Cited by 469
Proton pump inhibitors: an update of their clinical use and pharmacokinetics
Shi, S., & Klotz, U. E. (2008) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-008-0538-y · Cited by 314
Adverse Effects of Long-Term Proton Pump Inhibitor Therapy
Sheen, E., & Triadafilopoulos, G. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1560-3 · Cited by 316
“Long-term PPI therapy at a regular dose was not associated with a significantly increased risk of CRC.”
BackgroundInfluential
Metadata
- Authors
- Robertson, D. J., Larsson, H., Friis, S., Pedersen, L., Baron, J. A., & Sørensen, H. T.
- Affiliations
- Dartmouth–Hitchcock Medical Center (US)
- Aarhus University Hospital (DK)
- Danish Cancer Society (DK)
- Corresponding author
- Robertson, Douglas J.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 133
- Issue
- 3
- Pages
- 755-760
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1977659216
- Cited by
- 139
- References
- 51
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 1 · 2021: 9 · 2020: 17 · 2019: 3 · 2018: 7 · 2017: 10 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 7 · 2012: 8
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Keywords
- proton pump inhibitors, colorectal cancer, hypergastrinemia, serum gastrin, cancer risk, drug use, long-term PPI use
- MeSH terms
- Aged, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Denmark, Dose-Response Relationship, Drug, Female, Gastrins, Histamine H2 Antagonists, Humans, Hypoglycemic Agents, Intestinal Mucosa, Male, Risk Factors, Time Factors, Colorectal Neoplasms, Logistic Models, Case-Control Studies, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Cell Proliferation, Proton Pump Inhibitors
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