Cited by 592Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and Disease

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects.

Open access

Korenblat, Kevin M., Fabbrini, Elisa, Mohammed, B. Selma, Klein, Samuel·2008·Gastroenterology

DOI 10.1053/j.gastro.2008.01.075PMC PMC2629391

Open this paper in CoChat — free account Open PDF

Abstract

Background & aims Nonalcoholic fatty liver disease is associated with insulin resistance and diabetes. The purpose of this study was to determine the relationship between intrahepatic triglyceride (IHTG) content and insulin action in liver (suppression of glucose production), skeletal muscle (stimulation of glucose uptake), and adipose tissue (suppression of lipolysis) in nondiabetic obese subjects.Methods A euglycemic-hyperinsulinemic clamp procedure and stable isotopically labeled tracer infusions were used to assess insulin action, and magnetic resonance spectroscopy was used to determine IHTG content, in 42 nondiabetic obese subjects (body mass index, 36 +/- 4 kg/m(2)) who had a wide range of IHTG content (1%-46%).Results Hepatic insulin sensitivity, assessed as a function of glucose production rate and plasma insulin concentration, was inversely correlated with IHTG content (r = -0.599; P < .001). The ability of insulin to suppress fatty acid release from adipose tissue and to stimulate glucose uptake by skeletal muscle were also inversely correlated with IHTG content (adipose tissue: r = -0.590, P < .001; skeletal muscle: r = -0.656, P < .001). Multivariate linear regression analyses found that IHTG content was the best predictor of insulin action in liver, skeletal muscle, and adipose tissue, independent of body mass index and percent body fat, and accounted for 34%, 42%, and 44% of the variability in these tissues, respectively (P < .001 for each model).Conclusions These results show that progressive increases in IHTG content are associated with progressive impairment of insulin action in liver, skeletal muscle, and adipose tissue in nondiabetic obese subjects. Therefore, nonalcoholic fatty liver disease should be considered part of a multiorgan system derangement in insulin sensitivity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1053/j.gastro.2008.01.075

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621
Nonalcoholic Fatty Liver Disease
Angulo, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011775 · Cited by 5,228
The Michigan Alcoholism Screening Test: The Quest for a New Diagnostic Instrument
Selzer, M. L. (1971) · American Journal of Psychiatry · doi:10.1176/ajp.127.12.1653 · Cited by 3,431
The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Adams, L. A., Lymp, J. F., St. Sauver, J., Sanderson, S. O., Lindor, K. D., Feldstein, A., & Angulo, P. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.04.014 · Cited by 2,890
Nonalcoholic Fatty Liver, Steatohepatitis, and the Metabolic Syndrome
Marchesini, G., Bugianesi, E., Forlani, G., Cerrelli, F., Lenzi, M., Manini, R., Natale, S., Vanni, E., Villanova, N., Melchionda, N., et al. (2003) · Hepatology · doi:10.1053/jhep.2003.50161 · Cited by 2,728
Nonalcoholic Fatty Liver Disease
Marchesini, G., Brizi, M., Bianchi, G., Tomassetti, S., Bugianesi, E., Lenzi, M., McCullough, A. J., Natale, S., Forlani, G., & Melchionda, N. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1844 · Cited by 2,581
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
Sanyal, A. J., Campbell–Sargent, C., Mirshahi, F., Rizzo, W. B., Contos, M. J., Sterling, R. K., Luketic, V. A., Shiffman, M. L., & Clore, J. N. (2001) · Gastroenterology · doi:10.1053/gast.2001.23256 · Cited by 2,078
Nonalcoholic fatty liver disease
Adams, L. A. (2005) · Canadian Medical Association Journal · doi:10.1503/cmaj.045232 · Cited by 1,658

Show all 41 references

Sorted by citations

Items 501–592 of 592

Labeled breath tests in patients with NASH: Octanoate oxidation relates best to measures of glucose metabolism
Mucinski, J. M., Perry, A. M., Fordham, T. M., Diaz‐Arias, A. A., Ibdah, J. A., Rector, R. S., & Parks, E. J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1172675 · Cited by 2
Hipertrigliceridemia, esteatosis hepática y riesgo cardiovascular
Brea, Á., Mosquera, D., Mostaza, J. M., Aranda, J. L., Argimón, J., Sanclemente, C., Mateo‐Gállego, R., Almagro, F., Plana, N., & Recarte, C. (2011) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2011.02.003 · Cited by 2
Avances en hígado graso no alcohólico
Sánchez, D. M. (2009) · Medicina Clínica · doi:10.1016/j.medcli.2008.10.015 · Cited by 2
Epidermal Growth Factor Receptor in Hepatic Endothelial Cells Suppresses MCP-1–Dependent Monocyte Recruitment in Diabetes
Zhang, X., Ohayon-Steckel, L., Coppin, E., Johny, E., Dasari, A., Florentin, J., Vasamsetti, S. B., & Dutta, P. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200557 · Cited by 2
Associations of Alanine Aminotransferase/Aspartate Aminotransferase, a Marker of Hepatosteatosis, with Adipose Tissue Insulin Resistance Index and Leptin/Adiponectin Ratio in Japanese Women
Minato-Inokawa, S., Tsuboi-Kaji, A., Honda, M., Takeuchi, M., Kitaoka, K., Kurata, M., Wu, B., Kazumi, T., & Fukuo, K. (2023) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2023.0118 · Cited by 2
Non- Alcoholic Fatty Liver Disease
Bankar, K. D., Kalam, S., & Sanap, G. (2025) · International Journal of Advanced Research in Science Communication and Technology · doi:10.48175/ijarsct-22960 · Cited by 2
The Liver in Metabolic Syndrome
D’Amore, S., Palasciano, G., & Moschetta, A. (2013) · Springer eBooks · doi:10.1007/978-3-319-01008-3_3 · Cited by 2
Tifacogin (Chiron Corp/Pharmacia Corp).
Sne, N., Ondiveeran, H. K., & Fox‐Robichaud, A. (2002) · PubMed · Cited by 2
Down-regulation of hepatic MBOAT7 by hyperinsulinemia favors steatosis development
Meroni, M., Dongiovanni, P., Rametta, R., Bassani, G. A., Badiali, S., Fargion, S. R., Romeo, S., Gatti, S., & Valenti, L. V. C. (2017) · Journal of Hepatology · doi:10.1016/s0168-8278(17)31627-6 · Cited by 2
Evaluation of Hepatic Steatosis with CT and Correlation with Anthropometric Measurements
Taydaş, O., & Koç, U. (2018) · Current Medical Imaging Formerly Current Medical Imaging Reviews · doi:10.2174/1573405614666181029115243 · Cited by 2
The role of Ad-36 and its E4orf-1 protein in modulating glycemic control
Dhurandhar, E. J. (2011) · Louisiana State University · doi:10.31390/gradschool_dissertations.1411 · Cited by 2
Endogenous GDF15 and FGF21 additively alleviate hepatic steatosis and insulin resistance in obese micePreprint
Patel, S., Haider, A., Álvarez-Guaita, A., Bidault, G., Moustafa, J. S. E.-S., Guiu‐Jurado, E., Tadross, J. A., Warner, J., Harrison, J., Virtue, S., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.08.495255 · Cited by 2
Reducing complications of metabolic dysfunction–associated steatotic liver disease
Wada, N., Iwaki, M., Kobayashi, T., Nakajima, A., & Yoneda, M. (2025) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2025.2502549 · Cited by 1
Moderate weight loss decreases lipedema-affected body fat mass in a woman who is lean with lipedema
Girolamo, G. D., Smith, G. I., Stein, R. I., Wright, T. F., & Klein, S. (2026) · JCEM Case Reports · doi:10.1210/jcemcr/luag018 · Cited by 1
Self-citation
Emerging Approaches for the Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease: The Application of Nanomedicines
Shi, T., Yue, H., Wang, W., Gao, Y., Xu, S., Gao, J., & Yin, C. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s603396 · Cited by 1
Hepatic Lipoprotein Production, Cardiometabolic Phenotypes, and Subtypes of Steatotic Liver Disease
Davidson, N. O. (2026) · Circulation Research · doi:10.1161/circresaha.126.327269 · Cited by 2
Precision nutrition in MASLD should incorporate metabolic and inflammatory phenotyping
Ntikoudi, A. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1820240 · Cited by 1
Patatin-like phosphatase domain-containing 3 genotype and quality of dietary fat modify the liver adiposity in men
Tauriainen, M.-M., Lankinen, M. A., Hakumäki, J. M., Lahtinen, O., Husso, M., Ågren, J. J., Laakso, M., & Schwab, U. (2026) · European Journal of Nutrition · doi:10.1007/s00394-026-04031-6 · Cited by 2
Hepatic Steatosis and Low‐Density Lipoprotein Cholesterol Response After Statin Initiation: A Prospective Cohort Analysis
Lau, K. C.-H., Wong, V. W., Kong, A. P. S., Wong, G. L., Lai, J. C., Chu, C. W., & Yip, T. C. (2026) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.70656 · Cited by 1
The effect of 10- versus 30-minutes of acute aerobic exercise on insulin and glucose in obese adults
Mishler, A. E. (2012) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1
Spectroscopie par résonance magnétique : le nouveau standard pour quantifier la stéatose hépatique ?
Guiu, B., Petit, J., Walker, P. M., Loffroy, R., Hillon, P., Brunotte, F., Krause, D., & Cercueil, J. P. (2009) · Gastroentérologie Clinique et Biologique · doi:10.1016/j.gcb.2009.05.011 · Cited by 1
The strange and critical intersection of hepatitis C and lipoprotein metabolism: “C-zing” the oil
Caldwell, S. H., Hoehn, K. L., & Hahn, Y. S. (2012) · Hepatology · doi:10.1002/hep.26091 · Cited by 1
Non-Alcoholic Fatty Liver Disease (NAFLD): A New Cardiovascular Risk Factor
Gavril, R. S. (2015) · Romanian Journal of Diabetes Nutrition and Metabolic Diseases · doi:10.1515/rjdnmd-2015-0026 · Cited by 1
Research advance on mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease
Hailin, L., & Xinhua, X. (2014) · Cited by 1
Manifestations of Liver Impairment and the Effects of MH-76, a Non-Quinazoline α1-Adrenoceptor Antagonist, and Prazosin on Liver Tissue in Fructose-Induced Metabolic Syndrome
Kubacka, M., Nowak, B., Zadrożna, M., Szafarz, M., Latacz, G., Marona, H., Sapa, J., Mogilski, S., Bednarski, M., & Kotańska, M. (2023) · Metabolites · doi:10.3390/metabo13111130 · Cited by 1
Association between Serum Free Fatty Acids and Clinical and Laboratory Parameters in Acute Heart Failure Patients
Klobučar, I., Hinteregger, H., Lechleitner, M., Trbušić, M., Pregartner, G., Berghold, A., Sattler, W., Frank, S., & Degoricija, V. (2023) · Biomedicines · doi:10.3390/biomedicines11123197 · Cited by 1
Insulin resistance and metabolic diseases - a review
Drabczyk, M., Kosyra, K., MAGDA, I., Marczyńska, Z., & Zyśk, A. (2024) · Journal of Education Health and Sport · doi:10.12775/jehs.2024.61.012 · Cited by 1
Sugars and Cardiovascular Disease
Rippe, J. M. (2014) · Springer eBooks · doi:10.1007/978-1-4899-8077-9_21 · Cited by 1
Changes in Alanine Aminotransferase/Aspartate Aminotransferase Ratio Are Associated with Changes in Insulin Resistance in Japanese Community-Dwelling Middle-Aged and Elderly Women
Kawamoto, R., Ninomiya, D., Kasai, Y., Kusunoki, T., Ohtsuka, N., Kumagi, T., & Abe, M. (2016) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2016.66021 · Cited by 1
STRUCTURAL AND FUNCTIONAL FEATURES OF THE LIVER IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE, DEPENDING ON THE SEVERITY OF OBESITY
Стаценко, М. Е., Туркина, С. В., Шилина, Н. Н., Kosivtsova, M. A., & Анатольевич, Б. П. (2018) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-157-9-38-44 · Cited by 1
Down-regulation of hepatic MBOAT7 by hyperinsulinemia favors steatosis development
Meroni, M., Dongiovanni, P., Longo, M., Rametta, R., Badiali, S., Fargion, S., Romeo, S., Gatti, S., & Valenti, L. V. C. (2018) · Journal of Hepatology · doi:10.1016/s0168-8278(18)30280-0 · Cited by 1
Role of fatty liver in metabolic syndrome
Fodor, M. (2010) · Orvosi Hetilap · doi:10.1556/oh.2010.28897 · Cited by 1
Nature vs nurture: genetic susceptibility and weight loss in hepatic steatosis
Huang, K. (2010) · Clinical Genetics · doi:10.1111/j.1399-0004.2010.01519_3.x · Cited by 1
the Chicken or the Egg: Adipocytes and Hepatic Insulin Resistance
Hebbard, L., & George, J. (2010) · Hepatology · doi:10.1002/hep.23580 · Cited by 1
Long non-coding RNA Gm12664 up-regulates CAV1 expression to promote hepatocellular lipid accumulation by sponging miR-295-5pPreprint
Xu, F., Wang, L., Chen, L., Zhang, Q., & Na, L. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.15.951095 · Cited by 1
Causes and consequences of lipid overload in skeletal muscle, liver and heart
Bilet, L. (2015) · Research Publications (Maastricht University) · doi:10.26481/dis.20150702lb
Effects of diet intervention on body composition and ectopic fat accumulation in obese postmenopausal women
Mellberg, C. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Uso de la técnica de perifusión de células hepáticas de rata en la investigación de las acciones metabólicas y mitocondriales directas de dos tiazolindionas, pioglitazona y rosiglitazona
García, M. D. L. N. S. (2010) · doi:10.14201/gredos.83188
Nutritional modulation of hepatic lipid metabolism in health and disease
Johnston, R. D. (2012) · Nottingham ePrints (University of Nottingham)
Chinese Herbal Products in the Prevention and Treatment of Liver Disease
Gyamfi, D., Everitt, H. E., & Patel, V. B. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-397154-8.00013-0
The role of free fatty acids in ectopic lipid accumulation, insulin resistance and inflammation in humans.
van Herpen, N. A. (2012) · Research Publications (Maastricht University) · doi:10.26481/dis.20120426nh
Insulin therapy in type 2 diabetes : Initiation, impact on liver fat, role of combination therapy with glitazones or glindes
Juurinen, L. (2014) · Työväentutkimus Vuosikirja
New perspectives on childhood obesity
Fodor, M., & Sófi, G. (2013) · Orvosi Hetilap · doi:10.1556/oh.2013.29663
Effect of NAFLD on Regulation of Hepatic Transporters and Metaboic Enzymes Using a High Fat/ High Cholesterol Dietary Model in Rats
Feng, T. T. Q. (2012) · TSpace (University of Toronto)
Nonalcoholic Fatty Liver Disease and Extra-hepatic Malignancy
Albert, D. M., & Torres, D. M. (2014) · Current Hepatology Reports · doi:10.1007/s11901-014-0213-y
Hepatic Lipid Metabolism and Herbal Impacts on Non-Alcoholic Fatty Liver Disease
Liong, T. H. E. C. (2013) · Journal of Food & Nutritional Disorders · doi:10.4172/2324-9323.1000122
Perinatal essential fatty acid deficiency in mice - effects on metabolism and behaviour
Pálsdóttir, V. (2011) · Gothenburg University Publications Electronic Archive (Gothenburg University)
On Glucose Metabolism in Patients with the m.3243A>G Mutation
Lindroos, M. M. (2013) · UTUPub (University of Turku)
CLINICAL—LIVER, PANCREAS, AND BILIARY TRACT
Amaro, A., Fabbrini, E., Kars, M., Yue, P., Schechtman, K. B., Schonfeld, G., & Klein, S. (2010)
Self-citation
Dietary Fatty Acids, Body Composition and Ectopic Fat : Results from Overfeeding Studies in Humans
Rosqvist, F. (2016) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Reply
Singh, G. K., Magkos, F., & Klein, S. (2013) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2013.06.059
Self-citation
CLINICAL—LIVER, PANCREAS, AND BILIARY TRACT SAFETY Study: Alanine Aminotransferase Cutoff Values Are Set Too High for Reliable Detection of Pediatric Chronic Liver Disease
Schwimmer, J. B., Dunn, W., Norman, G. J., Pardee, P. E., Middleton, M. S., Kerkar, N. N., & Sirlin, C. B. (2010)
Heart Disease and the Liver: Interactions Between the Heart and the Liver
Yoshihisa, A., & Takeishi, Y. (2016) · Springer eBooks · doi:10.1007/978-4-431-55790-6_9
Metabolic and Endocrine Responses to Overeating.
Cornford, A. S. (2012) · Deep Blue (University of Michigan)
Effect of Disease State on Human Carboxylesterase 1 Expression and Activity
Aljutayli, A. (2016) · doi:10.23860/thesis-aljutayli-abdullah-2016
Rôle de la synthase inductible du monoxyde d'azote dans les maladies proinflammatoires et la résistance à l'insuline associée à l'obésité
Centeno-Baez, C. (2015)
POTENTIAL OF RUBUS ULMIFOLIUS SCHOTT SUPPLEMENTATION IN THE ATTENUATION OF SUCROSE-INDUCED HYPERGLYCEMIA, DYSLIPIDEMIA AND LIVER OXIDATIVE DAMAGE IN RATS
Madani, Z. (2017) · Journal of Diabetes and Obesity · doi:10.15436/2376-0494.16.1141
Towards the complete picture
Bohler (2017) · doi:10.26481/dis.20170216abd
Prevention of diabetes through lifestyle intervention
Drummen, M. (2019) · Research Publications (Maastricht University) · doi:10.26481/dis.20190124md
A34 EFFECT OF AUTOPHAGY INDUCTION VIA TRPML1 ACTIVATION ON HEPATIC STEATOSIS
Tersigni, C., Capurro, M., MacParland, S. A., Selzner-Malekkiani, N., & Jones, N. L. (2019) · Journal of the Canadian Association of Gastroenterology · doi:10.1093/jcag/gwz006.033
Heat Shock Protein 72 Regulation of Metabolism
Archer, A. E. (2018) · KU ScholarWorks (The University of Kansas)
Berberine Depresses Hepatocellular Lipogenesis Via Targeting to Methyltransferase SETD2Preprint
Li, D., Lü, S., Shen, T., Chen, J., & Li, Y. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4003196
Energy metabolism in relation to diet and physical activity
Wulan, S. N. (2015) · doi:10.26481/dis.20151112sw
Exercise and training in NAFLD and insulin resistance
Brouwers, B. (2016) · Research Publications (Maastricht University) · doi:10.26481/dis.20160624bb
Computed tomography evaluation of skeletal muscle quality and quantity in morbidly obese individuals with and without metabolic abnormalityPreprint
Kwon, S. H., Oh, E., Cho, N., Kang, H., Kim, S. H., & Park, H. K. (2022) · Research Square · doi:10.21203/rs.3.rs-1552951/v1
Alanine Aminotransferase, Body Mass Index, and Hemoglobin A1c May Be Useful Markers for Monitoring Changes in Intrahepatic Lipid Content in Japanese Patients With Overweight or Obesity and Type 2 Diabetes
Takemoto, A., Sada, Y., Oyanagi, T., Sasaki, Y., Sone, M., & Tanaka, Y. (2022) · Journal of Endocrinology and Metabolism · doi:10.14740/jem803
Screening for Wilson's disease in acute liver failure: A comparison of currently available diagnostic tests #
Cali, A. M. G., & Caprio, S. (2009) · Hepatology · doi:10.1002/hep.23056
Lifestyle treatment in the regression of NASH: insulin resistance, lipid synthesis, and methodological innovation
Mucinski, J. M. (2022) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/93980
RECENT APPROACHES FOR SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITORS IN THE MANAGEMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE
Heeba, G. H., Abolnaga, M., & Othman, E. M. (2023) · Bulletin of Pharmaceutical Sciences Assiut · doi:10.21608/bfsa.2023.301257
Editorial: Diabetes and non-alcoholic fatty liver disease: points of physiological and mechanistic intersection and current co-therapeutic approaches
Giannoukakis, N., & McCommis, K. S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1253604
Geranylgeranyl pyrophosphate (GGPP) is associated with hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4Preprint
Zhao, Y., Jiang, S., Nie, H.-Y., Zhao, M., Sun, P., Zhang, J., Wang, X., Tang, Y., Yuan, X., Sun, X., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.19.558458
Pathogenesis and research progress of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
Shan, G.-Y., Wan, H., Zhang, Y., Cheng, J.-Y., Qiao, D.-R., Liu, Y.-Y., Shi, W., & Li, H. (2024) · World Journal of Hepatology · doi:10.4254/wjh.v16.i10.1322
Animal models of nonalcoholic fatty liver disease
Kaur, S., & Tripathi, D. M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-99478-1.00004-3
Whole body and hematopoietic cell-specific deletion of G-protein coupled receptor 65 (GPR65) improves insulin sensitivity in diet-induced obese mice
Zhou, Y., Bae, E., Hoffman, S. S., Oh, D. Y., Smith, G. I., Klein, S., & Talukdar, S. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102169
Self-citation
The IRβ/HCF-1/ChREBP axis: A new paradigm in insulin-regulated hepatic lipogenesis
Song, R., Li, K., He, H., Xu, S., Yang, X., Tang, Y., Zhao, C., Yang, Q., Yin, G., & Cai, H. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.124046
Origins and consequences of altered metabolic processes in obese pregnant women
Barr, S. M. (2013) · ERA
Additional file 2 of The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
Nie, Q., Li, M., Huang, C., Yongwei, Y., Liang, Q., Ma, X., Qiu, T., & jianhong, L. I. (2024) · Figshare · doi:10.6084/m9.figshare.26687729
Additional file 1 of The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
Nie, Q., Li, M., Huang, C., Yongwei, Y., Liang, Q., Ma, X., Qiu, T., & Li, J. (2024) · Figshare · doi:10.6084/m9.figshare.26687726
Association of GLP ‐1 Receptor Agonists With Hepatic Decompensation in the All of Us Research Program
Hwang, I., Kim, Y., & Lee, S. W. (2026) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70668
Les mécanismes de réponse à l'inflammation chronique dans le foie stéatosique et les conséquences sur l'homéostasie cellulaire et la cancérogénèse
Esposti, D. D. (2011) · theses.fr (ABES) · doi:10.70675/b2a8993cz0743z4be8z979cz0a5a932b5326
Régulation des propriétés de deux enzymes clefs du métabolisme glucido-lipidique hépatique, la GlucoKinase et la Fatty Acid Synthase par O-GlcNAcylation au cours de la lipogenèse et de la prolifération cellulaire
Baldini, S. F. (2016) · theses.fr (ABES) · doi:10.70675/1cf3a250zd040z4f5fz8d08z0f78352c747e
La plaquette sanguine : un nouvel acteur du syndrome hémorragique de Noonan et du développement des maladies métaboliques
Bellio, M. (2020) · theses.fr (ABES) · doi:10.70675/2226e8e5zcf59z4cc2zaf52z551806010983
Mise au point d’un nouvel outil diagnostique de l’obésité sarcopénique : relations avec la dysfonction du tissu adipeux, l’insulinorésistance et la sévérité de l’atteinte hépatique
Azevedo, V. Z. (2024) · theses.fr (ABES) · doi:10.70675/6f7a5047ze3eaz482fzaae4zb7f1dc7abc0a
Metabolic dysfunction-associated steatotic liver disease in spinal cord injury and obesity: A narrative review of divergent mechanisms, convergent outcomes
Chang, D., McTigue, D. M., & Bruno, R. S. (2026) · Nutrition Research · doi:10.1016/j.nutres.2026.04.003
Modified Citrus Pectin-Mediated Gal-3 Reduction Attenuates Metabolic Dysfunction-Associated Steatohepatitis in an Experimental Model
Santos, A. R. M., da Cruz, A. G., de Camargo, F. N., dos SANTOS, J. D. M., Model, J. F. A., Silva, J. F. T., Matos, S. L., Araujo, L. C. C., & Camporez, J. P. (2026) · Cells · doi:10.3390/cells15171544
Cell-specific cPGES control of glucocorticoid receptor function drives MASLD progression
Zhong, D., Qiao, R., Quan, G., Song, C., Fu, K., Zou, Y., Qi, X., Su, W., Liu, Y., Li, F., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117901
Machine-learning-based prediction model of type 2 diabetes using liver enzymes: a cross-sectional study
Bi, Y., Yuan, X., Wang, Y., Sun, C., & Tian, S. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1905144
BindingDB Entry 50043347: Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure.
BindingDB (2014) · UC San Diego · doi:10.7270/q2jw8g9d
BindingDB Entry 50046721: Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
BindingDB (2016) · UC San Diego · doi:10.7270/q2w37z4r
Liver and Fat in Type 2 Diabetes: New Insights and Clinical Relevance
Nandave, M., Ramdhave, A. S., & Goyal, R. K. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9317-4_15
The role of ARNT in liver and myeloid cell function
Scott, C. H. (2013) · The Sydney eScholarship Repository (The University of Sydney)
Treinamento aeróbio na prevenção da doença hepática não alcoólica decorrente da obesidade em ratos
de Moura, L. P. (2013) · Aleph UCLA Undergraduate Research Journal for the Humanities and Social Sciences

Authors: Korenblat, K. M., Fabbrini, E., Mohammed, B. S., & Klein, S.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Klein, Samuel
ORCID: Korenblat, Kevin M.
Fabbrini, Elisa
Klein, Samuel
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2008-05
Volume: 134
Issue: 5
Pages: 1369-1375
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2008.01.075
PMC: PMC2629391
OpenAlex: W2071867050
Semantic Scholar: 583ea7ff89ae3ebd20b01708b92228e15c0f7b02
Cited by: 592
References: 41
Citations by year: 2026: 14 · 2025: 20 · 2024: 31 · 2023: 40 · 2022: 36 · 2021: 32 · 2020: 21 · 2019: 27 · 2018: 32 · 2017: 32 · 2016: 32 · 2015: 32 · 2014: 36 · 2013: 38 · 2012: 44
FWCI: 30.68
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
Funders: National Institutes of Health (DK 37948, DK 56341, RR-00954, RR-00036)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: intrahepatic triglyceride, insulin resistance, non-alcoholic fatty liver disease, hepatic insulin sensitivity, skeletal muscle glucose uptake, adipose tissue lipolysis, glucose production, obesity
MeSH terms: Adipose Tissue, Adult, Energy Metabolism, Female, Humans, Insulin, Insulin Resistance, Liver, Magnetic Resonance Imaging, Male, Magnetic Resonance Spectroscopy, Obesity, Prognosis, Risk Factors, Triglycerides, Glucose Clamp Technique, Biomarkers, Absorptiometry, Photon, Body Mass Index, Muscle, Skeletal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks