Cited by 793Immune cells in cancerImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

Open access

Hoechst, Bastian, Ormandy, Lars A., Ballmaier, Matthias, Lehner, Frank, Krüger, Christine, Manns, Michael P., Greten, Tim F., Korangy, Firouzeh·2008·Gastroenterology

DOI 10.1053/j.gastro.2008.03.020

Open this paper in CoChat — free account Open PDF

Abstract

Background & aims Several studies have shown that development of hepatocellular carcinoma (HCC) generates a number of immune suppressive mechanisms in these patients. Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of cells that have been shown to inhibit T-cell responses in tumor-bearing mice, but little is known about these cells in humans owing to a lack of specific markers. In this study, we have investigated the frequency and function of a new population of MDSC denoted here as CD14(+)HLA-DR(-/low) in HCC patients. We have also identified a novel, MDSC-mediated immune regulatory pathway in these patients.Methods We have directly isolated and characterized MDSCs for phenotype and function from peripheral blood (n = 111) and tumor (n = 12) of patients with HCC.Results The frequency of CD14(+)HLA-DR(-/low) cells in peripheral blood mononuclear cells (PBMC) from HCC patients was significantly increased in comparison with healthy controls. CD14(+) HLA-DR(-/low) cells were unable to stimulate an allogeneic T-cell response, suppressed autologous T-cell proliferation, and had high arginase activity, a hallmark characteristic of MDSC. Most important, CD14(+)HLA-DR(-/low) cells from HCC patients induced a CD4(+)CD25(+)Foxp3(+) regulatory T-cell population when cocultured with autologous T cells.Conclusion CD14(+)HLA-DR(-/low) cells are a new population of MDSC increased in blood and tumor of HCC patients. We propose a new mechanism by which MDSC exert their immunosuppressive function, through the induction of CD4(+)CD25(+)Foxp3(+) regulatory T cells in cocultured CD4(+) T cells. Understanding the mechanism of action of MDSC in HCC patients is important in the design of effective immunotherapeutic protocols.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1053/j.gastro.2008.03.020

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M., Conejo-Garcia, J. R., Zhang, L., Burow, M., et al. (2004) · Nature Medicine · doi:10.1038/nm1093 · Cited by 5,151
Regulatory T cells, tumour immunity and immunotherapy
Zou, W. (2006) · Nature reviews. Immunology · doi:10.1038/nri1806 · Cited by 2,135
Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells
Jonuleit, H., Schmitt, E., Schuler, G., Knop, J., & Enk, A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1213 · Cited by 1,538
Immune surveillance of tumors
Swann, J. B., & Smyth, M. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31405 · Cited by 1,518
Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
Huang, B., Pan, P.-Y., Li, Q., Sato, A. I., Levy, D. E., Bromberg, J., Divino, C. M., & Chen, S.-H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1299 · Cited by 1,435
Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer
Almand, B., Clark, J. I., Nikitina, E., van Beynen, J., English, N. R., Knight, S. C., Carbone, D. P., & Gabrilovich, D. I. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.678 · Cited by 1,340
Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses
Rodriguez, P. C., Quiceno, D. G., Zabaleta, J., Ortiz, B., Zea, A. H., Piazuelo, M. B., Delgado, A., Correa, P., Brayer, J., Sotomayor, E. M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0465 · Cited by 1,276
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
Nagaraj, S., Gupta, K., Писарев, В. М., Kinarsky, L., Sherman, S., Kang, L., Herber, D. L., Schneck, J. P., & Gabrilovich, D. I. (2007) · Nature Medicine · doi:10.1038/nm1609 · Cited by 1,176
Intratumoral Balance of Regulatory and Cytotoxic T Cells Is Associated With Prognosis of Hepatocellular Carcinoma After Resection
Gao, Q., Qiu, S., Fan, J., Zhou, J., Wang, X., Xiao, Y., Xu, Y., Li, Y., & Tang, Z. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.09.4565 · Cited by 1,134
Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients.
Schmielau, J., & Finn, O. J. (2001) · PubMed · Cited by 867

Show all 31 references

Sorted by citations

Items 701–790 of 790

Interactions and communications in hepatocellular carcinoma: Potential targets for chemo/radiosensitization
Yan, X., Dong, X., Yao, L., Guo, M., & Wang, N. (2026) · Pathology - Research and Practice · doi:10.1016/j.prp.2026.156425 · Cited by 1
Metabolic reprogramming and the tumor microenvironment in hepatocellular carcinoma: mechanisms and therapeutic targeting
Ruan, Z., & Sun, X. (2026) · Hepatoma Research · doi:10.20517/2394-5079.2025.58 · Cited by 1
Immunotherapy and Hepatocellular Carcinoma: From Tumor-Immune Cell Interactions to Rational Therapeutic Strategies
Yuza, K., & Pawlik, T. M. (2026) · Cells · doi:10.3390/cells15121097 · Cited by 1
Myeloid-Derived Suppressor Cells in Cancer: Metabolic Reprogramming, Immune Crosstalk, and Therapeutic Targeting
Sabatini, A., Assenza, M. R., Bilotta, M. T., Vacca, P., & Tumino, N. (2026) · Cancers · doi:10.3390/cancers18132150 · Cited by 1
Immunosuppresssion and Immune Escape in Liver Cancer
Wang, Q., & Cao, X. (2012) · Springer eBooks · doi:10.1007/978-3-642-28702-2_9 · Cited by 1
Regulatory T Cells and Th17 Cells in Cancer Microenvironment
Kim, C. H. (2014) · Springer eBooks · doi:10.1007/978-3-662-44006-3_6 · Cited by 1
Analysis of Myeloid-Derived Suppressor Cells in Patients with Cancer
Zhu, P., Segal, Y. V., Shurin, G. V., & Shurin, M. R. (2013) · Springer eBooks · doi:10.1007/978-94-007-6217-6_31 · Cited by 1
Progress of Immunotherapy for Hepatocellular Carcinoma
Ma, H. (2013) · ImmunoGastroenterology · doi:10.7178/ig.48 · Cited by 1
Myeloid-derived Suppressor Cells in Autoimmune Diabetes: Their Antidiabetic Potential and Mechanism
Yang, W. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s12-004 · Cited by 2
Secondary Alterations of Hepatocellular Carcinoma
Zimmermann, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-26956-6_5 · Cited by 1
Myeloid-Derived Suppressor Cells in Cancer
Badn, W., & Bronte, V. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9914-6_12 · Cited by 1
Liver Cancer - Genesis, Progression and Metastasis
Feitelson, M. A., & Arzumanyan, A. L. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.100845 · Cited by 1
Functional Flow Cytometry to Predict PD‐L1 Conformational Changes
Salvia, R., Rico, L. G., Ward, M. D., Bradford, J. A., & Pétriz, J. (2023) · Current Protocols · doi:10.1002/cpz1.944 · Cited by 1
Arginina y cáncer: implicaciones en la regulación de la respuesta antitumoral
Correa, J. M. I., Gutiérrez, C. M. V., & Lopera, M. M. V. (2013) · IATREIA · doi:10.17533/udea.iatreia.14293 · Cited by 1
Basic Principles of Immunology in Urology
Flechner, S. M., Finke, J. H., & Fairchild, R. L. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-6911-9.00017-7 · Cited by 1
MIF-Dependent Regulation of Monocyte/Macrophage Polarization
Yaddanapudi, K., & Mitchell, R. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-52354-5_4 · Cited by 1
Antigen-Specific T Cell Responses in Hepatocellular Carcinoma
Mizukoshi, E., & Kaneko, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-64958-0_3 · Cited by 1
Regulatory T Cells in Colorectal Cancer
Jafariniaorcid, M., Lotfiorcid, N., Ganjalikhani-hakmiorcid, M., & Rezaei, A. (2018) · Immunoregulation · doi:10.32598/immunoregulation.1.1.5 · Cited by 1
Immunotherapy in Immunosuppressed Patients
Oberoi, H. K., & Valpione, S. (2021) · Springer eBooks · doi:10.1007/978-3-030-64009-5_22 · Cited by 1
Targeted delivery and reprogramming of myeloid-derived suppressor cells (MDSCs) in cancer
Katoh, H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85781-9.00015-4 · Cited by 1
Development of Immunotherapy for Hepatocellular Carcinoma
Mizukoshi, E., & Kaneko, S. (2015) · Springer eBooks · doi:10.1007/978-4-431-55327-4_10
Constraints on the CD8 T cell response in chronic HBV infection
Das, A. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
Anti-tumor and pro-tumor interactions of human NK cells in cancer
Wong, J. L. (2013) · D-Scholarship@Pitt (University of Pittsburgh)
Reversing Breast Cancer-Induced Immune Suppression
Beury, D. W., & Ostrand‐Rosenberg, S. (2013) · doi:10.21236/ada573503
Is Immune Modulation a Possibility?
Greten, T. F., & Korangy, F. (2011) · Wiley eBooks · doi:10.1002/9781119962205.ch27
Self-citation
Biomarkers in sepsis and other severe infections
Janols, H. (2014) · Lund University Publications (Lund University)
Tumor surveillance and immune evasion: the interplay between the immune system and tumor cells
van Altena, S. E. C. (2011) · Utrecht University Repository (Utrecht University)
The Clinical Impact of the Dendritic Cell-based Cancer Vaccine: the Role in the Inflammatory Tumor Micro-environment
Lee, H. (2010) · Chonnam Medical Journal · doi:10.4068/cmj.2010.46.1.1
Myeloid-Derived Suppressive Cells and Their Regulatory Mechanisms in Cancer
Ma, G., Pan, P., & Chen, S. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9914-6_13
Tumor and Iatrogenic Regulation of Myeloid Precursors and their Potential to Limit Immune Therapy
Talmadge, J. E., Cowan, K. H., & Reed, E. C. (2008) · Immunotherapy · doi:10.2217/1750743x.1.1.5
Crosstalk of human mesenchymal stromal cells with the cellular components of the immune system
Jitschin, R. (2013) · Figshare
Tumor-mediated changes in the immune system of cancer patients - a balancing act between suppressors and effectors
Poschke, I. C. (2011) · Figshare
Review on role of Myeloid-derived Suppressor cells in regulation of immune system
Mesali, H., Shadman, M., Tehrani, M., & Ajami, A. (2013) · Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Māzandarān/Journal of Mazandaran University of Medical Sciences
The Dual Role of Myeloid- Derived Suppressor Cells in Liver Pathologies
Monteleone, G., Fusco, D. D., Cupi, M. L., Figliuzzi, M. M., & Pallone, F. (2014)
Inflammation, Tumor Progression, and Immune Suppression
Ostrand‐Rosenberg, S., & Sinha, P. (2013) · Springer eBooks · doi:10.1007/978-94-007-6217-6_7
Post-Surgical Natural Killer T Cell Activation as a Potential Therapy for Metastatic Breast Cancer
Clattenburg, D. R. (2015)
T Cell Fate in the Tumor Microenvironment
Crespo, J., Kryczek, I., Welling, T. H., Wei, S., & Zou, W. (2015) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-21167-1_3
Tumor Exosomes and Their Impact on Immunity and Cancer Progression
Huber, V., Filipazzi, P., & Rivoltini, L. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394296-8.00030-0
Controversies in Neoplastic Myeloplasia
Talmadge, J. E. (2016) · SpringerBriefs in immunology · doi:10.1007/978-3-319-26821-7_1
Role of the Immune System in Hepatocellular Carcinoma: Implications for Existing and Novel Therapies
Flecken, T., & Thimme, R. (2016) · Springer eBooks · doi:10.1007/978-3-319-34214-6_13
Original Article Immunotherapy with immunomodulatory antibody for hepatocellular carcinoma
Huang, L. (2015)
Secondary Alterations of Hepatocellular Carcinoma
Zimmermann, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-26587-2_5-1
PD1 and PD-L1 Immune Checkpoint Inhibitors in Gastrointestinal Cancer
Pectasides, E., & McDermott, D. F. (2017) · Springer eBooks · doi:10.1007/978-3-319-43063-8_6
Identification of Myeloid Derived Suppressor Cells in Tumor Bearing Dogs
Sherger, M. (2012) · OhioLink ETD Center (Ohio Library and Information Network)
Modulating Immune Responses to Overcome Resistance in Hepatocellular Carcinoma
D’Avola, D., & Sangro, B. (2017) · Resistance to targeted anti-cancer therapeutics · doi:10.1007/978-3-319-56197-4_2
Immune Suppressor Mechanisms in HCC
Greten, T. F., & Korangy, F. (2017) · Springer eBooks · doi:10.1007/978-3-319-64958-0_8
Self-citation
Natural Killer Cells in Hepatocellular Carcinoma: Anti-Tumor Effect and Therapeutic Potential
Cariani, E., & Missale, G. (2017) · Springer eBooks · doi:10.1007/978-3-319-64958-0_2
Evolving Immunotherapy Approaches for Hepatocellular Carcinoma
Takahashi, K., & Marusawa, H. (2017) · Current human cell research and applications · doi:10.1007/978-981-10-6469-2_6
THE IMPACT OF HISTAMINE RECEPTOR 2 ANTAGONISTS ON BREAST CANCER DEVELOPMENT AND MONOCYTIC POPULATIONS
Vila, A. (2018) · DalSpace (Dalhousie University)
MDS Stem Cell Biology
Villaume, M. T., Ferrell, P. B., & Savona, M. R. (2020) · Springer eBooks · doi:10.1007/978-3-030-51878-3_4 · Cited by 1
MECHANISM OF MYELOID-DERIVED SUPPRESSOR CELL ACCUMULATION IN CANCER AND SUSCEPTIBILITY TO REVERSAL BY SUNITINIB
Ko, J. S. (2009) · OhioLink ETD Center (Ohio Library and Information Network)
The Role of Nuclear Factor Kappa B in Myeloid Cells During Lung Carcinogenesis
Perry, A. G. (2016)
Hepatobiliary Cancers and Immunology
Kodama, T., & Takehara, T. (2020) · Springer eBooks · doi:10.1007/978-3-030-51709-0_31
Mechanisms for immune escape in epithelial ovarian cancer
Israelsson, P. (2021) · DiVA at Umeå University (Umeå University)
Immunoregulation by HCV-generated Myeloid Suppressor Cells
Yergin, C. G. (2016) · doi:10.18130/v39z95
Translational research in chronic liver diseases
Segovia, J., & Simó, M. R. (2020) · DIGITAL.CSIC (Spanish National Research Council (CSIC))
Biological therapies in patients with liver disease: are they really lifesavers?
Vitale, G., Gitto, S., Campani, C., Turco, L., Baldan, A., Marra, F., & Morelli, M. C. (2021) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2022.2013799
Lymphocytes in Liver Cancer
Xu, X., Cho, W. C. S., & Xia, J. (2015) · Translational bioinformatics · doi:10.1007/978-94-017-9753-5_9
Neutrophil activation induces peripheral immunosuppression in glioblastoma and stroke
Berger, T. R. (2013) · doi:10.25677/fmzs-7757
Role of Arginase 1 and Nitric Oxide Synthase 2 as enzymatic mediators of the immunosuppressive activity in tumor-infiltrating myeloid derived suppressor cells
Zilio, S. (2012) · Padua Research Archive (University of Padova)
IL-35 ameliorates psoriasis by suppressing the accumulation of iNOS-expressing myeloid-derived suppressor cellsPreprint
Zhang, J., Zhang, Y., Yang, Z., Cheng, D., Zhang, H., Li, W., Liu, C., Fu, J., Yan, F., Li, C., et al. (2022) · doi:10.22541/au.164407908.87135419/v1
Immunotherapy for hepatocellular cancer: a review of current status
Yu, J. B., Zaytsev, V., Farooq, A., Jalil, A., Wert, J., Ahmed, Z., & Ahmad, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99283-1.00022-7
Emerging Immunotherapy: Liver Cancer Microenvironment for Treatment
Liu, S. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.106021
Myeloid-derived suppressor cells in multiple myeloma patients at the immune recovery and after high-dose chemotherapy and hematopoietic stem cell transplantation
Викторовна, Т. Т., Васильевич, Б. Е., Aristova, T. A., Ushakova, G. Y., Анатольевна, С. С., Denisova, V. V., Ostanin, A. A., & Chernykh, E. R. (2022) · Siberian Journal of Oncology · doi:10.21294/1814-4861-2022-21-6-47-58
Data from Immature Immunosuppressive CD14+HLA-DR−/low Cells in Melanoma Patients Are Stat3hi and Overexpress CD80, CD83, and DC-Sign
Poschke, I. C., Mougiakakos, D., Hansson, J., Masucci, G. V., & Kiessling, R. W. (2023) · doi:10.1158/0008-5472.c.6500241.v1
Assessing the Influence of Immune Cell Traits on Hepatocellular Carcinoma Pathogenesis: A Mendelian Randomization InvestigationPreprint
Xu, Y., Sun, F., Xiao, C., Liu, R., & Yang, P. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4614934
Liver cancer
Huang, R., Ding, J., & Xie, W. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95262-0.00017-6
Impact of Reduction in Myeloid‐derived Suppressor Cells by Wilms’ Tumor 1‐targeted Dendritic Cell Vaccines on Clinical Outcomes in Acute Leukemia Patients
Ogasawara, M., Miyashita, M., Yamagishi, Y., & Ota, S. (2025) · eJHaem · doi:10.1002/jha2.70048
Characterization and clinical implications of myeloid-derived suppressor cells in head and neck cancer
Chikamatsu, K. (2012) · 耳鼻咽喉科免疫アレルギー · doi:10.5648/jjiao.30.271
Additional file 1 of Hepatic recruitment of myeloid-derived suppressor cells upon liver injury promotes both liver regeneration and fibrosis
Zhang, Q., Yu, T., Tan, H., & Shi, H. (2024) · Figshare · doi:10.6084/m9.figshare.25824754
Additional file 1 of SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma
Lin, J., Yan, J., Deng, X. L., Wang, C. S., & Wang, H. S. (2024) · Figshare · doi:10.6084/m9.figshare.26560754
Mechanical microenvironment and its role in hepatocellular carcinoma oncogenesis and progression
Guo, X., Xie, Y., Qian, R., Li, J., Shi, J., Huang, Q., & Shao, D. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.105099
Cyclophosphamide-Mediated Induction of Myeloid-Derived Suppressor Cells In Vivo: Kinetics of Accumulation, Immune Profile, and Immunomodulation by Oleanane-Type Triterpenoids
Awad, M. S., Васильевна, С. А., Markov, A. V., Salomatina, O. V., Аркадьевна, З. М., & Markov, O. V. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020564
Therapeutic potential of hookworm proteins in promoting regulatory immune responses to modulate Trypanosoma cruzi induced liver inflammation and oxidative stress
Villar, M. J., Poveda, C., Zhan, B., Gonsoulin, M., & Jones, K. M. (2026) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760250123
Aspects fonctionnels et pronostiques des cellules myéloïdes suppressives et de Foxp3 dans le cancer
Ladoire, S. (2011) · theses.fr (ABES) · doi:10.70675/f95be627zd09cz4fd2za49fz6b11ffb7363d
Increased regulatory B cells are involved in immune evasion in patients with gastric cancer
Murakami, Y., 2359, ムラカミ, ユ., 100001165, & Murakami, Y. (2020) · Institutional Repositories DataBase (IRDB)
Le rôle immunomodulateur dans la réponse allo-immune de cellules hématopoïétiques mobilisées par du G-CSF
D’Aveni, M. (2015) · theses.fr (ABES) · doi:10.70675/8f6b210az750az449bzabdbz0ce2f840d643
Impact de l’interleukine-17 sur les cellules progénitrices intra-hépatiques au cours de la régénération et dans l’initiation tumorale du foie
Gasmi, I. (2018) · theses.fr (ABES) · doi:10.70675/06aa1dd6z0c89z4f44z80ecz3970b09cbce1
Modèle de carcinomes hépatocellulaires murins induits par l'expression de l'antigène T SV40 : analyse du transcriptome entier du foie et des variations d'expression ARN liées à l'âge et induites par un régime « occidental »
Hobeika, C. (2022) · theses.fr (ABES) · doi:10.70675/4c247323z584fz42b6za12cze7812b01da9e
Effet anti-tumoral du GTN +/- doxorubicine dans le cancer du sein triple négatif : implication du système immunitaire
Mabrouk, N. (2021) · theses.fr (ABES) · doi:10.70675/8ef700b1zdb78z4da6z9da1zde8ca3e4700b
Rôles directs d'une chimiothérapie et vésicules libérées par le cancer sur les déficits cognitifs et/ou émotionnels dans des modèles précliniques
Parment, R. (2023) · theses.fr (ABES) · doi:10.70675/ede8abd2zb03az4e84zb2a0z9b6221997db2
Hepatocellular Carcinoma – from Immunobiology to Immunotherapy
Roehlen, N., Bengsch, B., Rennert, C., Schultheiß, M., & Thimme, R. (2026) · TumorDiagnostik & Therapie · doi:10.1055/a-2851-6473
Hepatocellular carcinoma tumor immune microenvironment: heterogeneity and therapeutic strategies
Mao, T., Jiang, J., Liu, P., Zhao, Y., Zhong, L., Zhang, Z., Wu, K., & Xia, L. (2026) · Hepatoma Research · doi:10.20517/2394-5079.2026.04
Mechanistic synergies and optimal sequencing of anti‑VEGF plus immune checkpoint inhibition in gastrointestinal cancers
Lorestani, P., Robat-Jazi, B., Nejati, N., Jazi, K., Faghihkhorasani, F., Khalili, A., Karimizadeh, Z., Kalantari, A., Mirsharifi, E., Hojjat, S. H., et al. (2026) · Discover Oncology · doi:10.1007/s12672-026-05539-3
Tumor-associated neutrophils crosstalk with non-cancerous components of the gastrointestinal tumor microenvironment
Łabędź, N., & Jacenik, D. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189670
Cyclooxygenases in pancreatic ductal adenocarcinoma: are they inflammatory catalysts for tumor growth
Orhan, A., Orhan, T., Raskov, H., & Gögenür, I. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1916208
Microbiome–Immune Interactions as Determinants of Checkpoint Inhibitor Efficacy in Hepatocellular Carcinoma
Ostafe, M. R., Volovăț, S. R., Clement, A., Litcanu, C.-I., Tabarcea, S., Volovăț, C. C., Panaite, D. I., Augustin, I. G., & Volovăț, C. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177543
The acidic tumor microenvironment in hepatocellular carcinoma: a barrier to adoptive cellular immunotherapy
Xiong, J., Mou, G., 泽塔多吉, Li, X., & Zhao, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1959235
Insights in the Immune Molecular Mechanisms of the Trilogy of Liver Cancer
Li, Y., Bin, F., Chunlei, G., & Hui, L. (2026) · Immune discovery. · doi:10.70322/immune.2026.10008
Baseline Host Biomarkers and Six-Month Sustained Drug-Free Status After Atezolizumab–Bevacizumab for Hepatocellular Carcinoma: Exploratory Clinical Stratification Using PAN-DF Score
Iino, C., Abe, T., Endo, K., Fujiwara, Y., Yoshida, K., Sato, S., Numao, H., Igarashi, G., Oikawa, T., Ninomiya, M., et al. (2026) · Cancers · doi:10.3390/cancers18203366

Authors: Hoechst, B., Ormandy, L. A., Ballmaier, M., Lehner, F., Krüger, C., Manns, M. P., Greten, T. F., & Korangy, F.
Affiliations: Medizinische Hochschule Hannover (DE)
Corresponding author: Korangy, Firouzeh
ORCID: Ballmaier, Matthias
Lehner, Frank
Manns, Michael P.
Greten, Tim F.
Korangy, Firouzeh
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2008-07
Volume: 135
Issue: 1
Pages: 234-243
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2008.03.020
OpenAlex: W2059688175
Cited by: 793
References: 31
Citations by year: 2026: 18 · 2025: 20 · 2024: 25 · 2023: 34 · 2022: 50 · 2021: 46 · 2020: 53 · 2019: 40 · 2018: 39 · 2017: 60 · 2016: 54 · 2015: 65 · 2014: 55 · 2013: 65 · 2012: 59
FWCI: 15.02
Type: journal article
Language: en
Update notices: erratum (2011-08-01)
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (SFB-738)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: myeloid-derived suppressor cells, hepatocellular carcinoma, regulatory T cells, immunosuppression, arginase activity, CD4+CD25+Foxp3+ T cells, tumor immune microenvironment, T cell proliferation inhibition, cancer immunotherapy
MeSH terms: Aged, Arginase, Cell Communication, Cell Division, Cells, Cultured, Female, Flow Cytometry, Carcinoma, Hepatocellular, HLA-DR Antigens, Humans, Immune Tolerance, Liver Neoplasms, Male, Middle Aged, Biomarkers, CD4-Positive T-Lymphocytes, CD4 Antigens, Immunophenotyping, Interleukin-10, Lipopolysaccharide Receptors, Myeloid Cells, Forkhead Transcription Factors, Interleukin-2 Receptor alpha Subunit

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks