Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes.

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Items 101–200 of 339

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2. Non-alcoholic fatty liver disease: a diabetologist’s perspective
   Joseph M Pappachan, Farrah A Antonio, Mahamood Edavalath, Arjun Mukherjee · 2013 · Endocrine
3. Cafeteria diet inhibits insulin clearance by reduced insulin-degrading enzyme expression and mRNA splicing
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4. Managing NAFLD in Type 2 Diabetes: The Effect of Lifestyle Interventions, a Narrative Review
   Sion A. Parry, Leanne Hodson · 2020 · Advances in Therapy
5. Chronic hyperinsulinemia promotes meta-inflammation and extracellular matrix deposition in adipose tissue: Implications of nitric oxide
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6. Hyperinsulinemia in individuals with obesity: Role of insulin clearance
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7. Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation
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8. Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice
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9. Intracellular role of exchangeable apolipoproteins in energy homeostasis, obesity and non‐alcoholic fatty liver disease
   Chenlu Wu, Shui‐Ping Zhao, Bilian Yu · 2014 · Biological reviews/Biological reviews of the Cambridge Philosophical Society
10. Non-Alcoholic Fatty Liver Disease and Cardiovascular Comorbidities: Pathophysiological Links, Diagnosis, and Therapeutic Management
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11. Ciliary neurotrophic factor (CNTF) protects non-obese Swiss mice against type 2 diabetes by increasing beta cell mass and reducing insulin clearance
    Luiz Fernando de Rezende, Gustavo Jorge dos Santos, Junia Carolina Santos-Silva, Everardo M. Carneiro, Antonio Carlos Boschero · 2012 · Diabetologia
12. Vitamin D3 intake as regulator of insulin degrading enzyme and insulin receptor phosphorylation in diabetic rats
    Mohamed Mahmoud Elseweidy, Rawia sarhan Amin, Hebatallah Husseini Atteia, Maha Abdo Ali · 2016 · Biomedicine & Pharmacotherapy
13. Clinical Features of Nonobese, Apparently Healthy, Japanese Men With Reduced Adipose Tissue Insulin Sensitivity.
    Daisuke Sugimoto, Y. Tamura, Kageumi Takeno, Hideyoshi Kaga, Yuki Someya, Saori Kakehi, Takashi Funayama, Yasuhiko Furukawa, Ruriko Suzuki, S. Kadowaki et al. · 2019 · Journal of Clinical Endocrinology and Metabolism
14. The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis—Dysregulation by the Liver
    Amalie London, Anne‐Marie Lundsgaard, Bente Kiens, Kirstine Nyvold Bojsen-Møller · 2021 · Journal of Clinical Medicine
15. Disruption of the sugar-sensing receptor T1R2 attenuates metabolic derangements associated with diet-induced obesity
    Kathleen R. Smith, Tania Hussain, Elnaz Karimian Azari, Jennifer L. Steiner, Julio E. Ayala, Richard E. Pratley, George A. Kyriazis · 2016 · American Journal of Physiology-Endocrinology and Metabolism
16. A heterogeneous response of liver and skeletal muscle fat to the combination of a Paleolithic diet and exercise in obese individuals with type 2 diabetes: a randomised controlled trial
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17. Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice
    Enrique Jurado‐Ruiz, Leticia Álvarez‐Amor, Lourdes M. Varela, Genoveva Berná, María S. Parra-Camacho, María‐Jesús Oliveras‐López, Enrique Martínez‐Force, Anabel Rojas, Abdelkrim Hmadcha, Bernat Soria et al. · 2019 · Scientific Reports
18. Pathogenesis of type 2 diabetes risk in black Africans: a South African perspective
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19. Insulin Clearance in Obesity and Type 2 Diabetes
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20. Dysregulated hepatic expression of glucose transporters in chronic disease: contribution of semicarbazide-sensitive amine oxidase to hepatic glucose uptake
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21. Effects of Pterostilbene on Diabetes, Liver Steatosis and Serum Lipids
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22. Nutrient infusion bypassing duodenum-jejunum improves insulin sensitivity in glucose-tolerant and diabetic obese subjects
    Serenella Salinari, Richard David Carr, Caterina Guidone, ALESSANDRO BERTUZZI, Stefania Cercone, Maria Elena Riccioni, Andrea Manto, Giovanni Ghirlanda, Geltrude Mingrone · 2013 · American Journal of Physiology-Endocrinology and Metabolism
23. Volume-dependent effect of supervised exercise training on fatty liver and visceral adiposity index in subjects with type 2 diabetes The Italian Diabetes Exercise Study (IDES)
    Stefano Balducci, Patrizia Cardelli, Luca Pugliese, Valeria D’Errico, Jonida Haxhi, Elena Alessi, Carla Iacobini, Stefano Menini, Lucilla Bollanti, F. Conti et al. · 2015 · Diabetes Research and Clinical Practice
24. Incretin based therapies: A novel treatment approach for non-alcoholic fatty liver disease
    Kristina Blaslov · 2014 · World Journal of Gastroenterology
25. PNPLA3 rs738409 underlies treatment response in nonalcoholic fatty liver disease
    Jinzhi Wang, Haixia Cao, Jian-Neng Chen, Qin Pan · 2018 · World Journal of Clinical Cases
26. Postprandial Insulin Response and Clearance Among Black and White Women: The Federal Women’s Study
    Stephanie Therese Chung, Mirella Galvan‐De La Cruz, Paola C. Aldana, Lilian S. Mabundo, Christopher W. DuBose, Anthony U. Onuzuruike, Mary F. Walter, Ahmed M. Gharib, Amber B. Courville, Arthur Sherman et al. · 2018 · The Journal of Clinical Endocrinology & Metabolism
27. The effects of insulin resistance on individual tissues: an application of a mathematical model of metabolism in humans
    Pearson, Taliesin, Wattis, Jonathan A. D., King, John R., MacDonald, Ian A., Mazzatti, Dawn J. · 2016 · Bulletin of Mathematical Biology
28. Changes in post-prandial glucose and pancreatic hormones, and steady-state insulin and free fatty acids after gastric bypass surgery
    Guilherme M. Campos, Charlotte Rabl, Peter Joseph Havel, Madhu N. Rao, Jean Marc Schwarz, Morris Schambelan, Kathleen M. Mulligan · 2013 · Surgery for Obesity and Related Diseases
29. Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes
    Michael Taulo Lund, Marianne Kristensen, Merethe Hansen, Louise Tveskov, Andrea Karen Floyd, Mikael Støckel, Ben Vainer, Steen Seier Poulsen, Jørn Wulff Helge, Clara Prats et al. · 2016 · The Journal of Physiology
30. Correlates of insulin clearance in apparently healthy non-obese Japanese men
    Hideyoshi Kaga, Yoshifumi Tamura, Kageumi Takeno, Saori Kakehi, Takashi Funayama, Yasuhiko Furukawa, Miho Nishitani‐Yokoyama, Kazunori Shimada, Hiroyuki Daida, Shigeki Aoki et al. · 2017 · Scientific Reports
31. Cephalic phase insulin release: A review of its mechanistic basis and variability in humans
    Alexa J. Pullicin, John I. Glendinning, Juyun Lim · 2021 · Physiology & Behavior
32. Hepatic IRS1 and ß-catenin expression is associated with histological progression and overt diabetes emergence in NAFLD patients
    Kenichiro Enooku, Mayuko Kondo, Naoto Fujiwara, Takayoshi Sasako, Junji Shibahara, Akira Kado, Kazuya Okushin, Hidetaka Fujinaga, Takeya Tsutsumi, Ryo Nakagomi et al. · 2018 · Journal of Gastroenterology
33. Risk factors for non-alcoholic fatty liver disease-associated hepatic fibrosis in type 2 diabetes patients
    Asieh Mansour, Mohammad Reza Mohajeri‐Tehrani, Majid Samadi, Hadis Gerami, Mostafa Qorbani, Nick Bellissimo, Hossein Poustchi, Azita Hekmatdoost · 2019 · Acta Diabetologica
34. Hepatocyte membrane potential regulates serum insulin and insulin sensitivity by altering hepatic GABA release
    Caroline E. Geisler, Susma Ghimire, Chelsea Hepler, Kendra E. Miller, Stephanie M Bruggink, Kyle P. Kentch, Mark R. Higgins, Christopher Todd Banek, Jun Yoshino, Samuel Klein et al. · 2021 · Cell Reports
35. Insulin resistance, postprandial GLP-1 and adaptive immunity are the main predictors of NAFLD in a homogeneous population at high cardiovascular risk
    Lutgarda Bozzetto, Giovanni Annuzzi, Monica Ragucci, Orlando Di Donato, Giuseppe Della Pepa, Giuseppina Della Corte, Ettore Griffo, Gaia Anniballi, Antonia Giacco, Marcello Mancini et al. · 2016 · Nutrition Metabolism and Cardiovascular Diseases
36. Effects of different exercise modalities on novel hepatic steatosis indices in overweight women with type 2 diabetes
    Ebrahim Banitalebi, Mohammad Faramarzi, Samira Nasiri, Majid Mardaniyan Ghahfarrokhi, Vahid Rabiee · 2019 · Clinical and Molecular Hepatology
37. Reduced Insulin Clearance Differently Relates to Increased Liver Lipid Content and Worse Glycemic Control in Recent-Onset Type 2 and Type 1 Diabetes
    O. Zaharia, Sofia Antoniou, Pavel Bobrov, Y. Karusheva, K. Bódis, Y. Kupriyanova, V. Schrauwen-Hinderling, A. Gastaldelli, J. Szendroedi, R. Wagner et al. · 2023 · Diabetes Care
38. Obesity and Postmenopausal Hormone Receptor-positive Breast Cancer: Epidemiology and Mechanisms
    Qianying Zuo, Shoham Band, Mrinali P. Kesavadas, Zeynep Madak‐Erdogan · 2021 · Endocrinology
39. Why Does NAFLD Predict Type 2 Diabetes?
    Guido Lattuada, Francesca Ragogna, Gianluca Perseghin · 2011 · Current Diabetes Reports
40. Higher serum levels of uric acid are associated with a reduced insulin clearance in non-diabetic individuals
    Teresa Vanessa Fiorentino, Franz Federico Sesti, Elena Succurro, Elisabetta Pedace, Francesco Andreozzi, Angela Sciacqua, Marta Letizia Hribal, Francesco Perticone, Giorgio Sesti · 2018 · Acta Diabetologica
41. The impact of high intensity interval training on liver fat content in overweight or obese adults: A meta-analysis
    Mousa Khalafi, Michael Edward Symonds · 2021 · Physiology & Behavior
42. Distribution of abdominal adipose tissue as a predictor of hepatic steatosis assessed by MRI
    Pierre‐Henri Ducluzeau, P. Manchec-Poilblanc, Vincent Roullier, E. Cesbron, Jerome Lebigot, Sandrine Bertrais, Christophe Aubé · 2010 · Clinical Radiology
43. Ethnic and sex differences in hepatic lipid content and related cardiometabolic parameters in lean individuals
    Kitt Falk Petersen, Sylvie Dufour, Fangyong Li, Douglas L. Rothman, Gerald I. Shulman · 2022 · JCI Insight
44. Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis
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45. The Interactions of Nonalcoholic Fatty Liver Disease and Cardiovascular Diseases
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46. Lower insulin clearance is associated with increased risk of type 2 diabetes in Native Americans
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47. Effects of Acupuncture Therapy on Abdominal Fat and Hepatic Fat Content in Obese Children: A Magnetic Resonance Imaging and Proton Magnetic Resonance Spectroscopy Study
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48. Helicobacter pylori infection aggravates diet-induced nonalcoholic fatty liver in mice
    Cong He, Dandan Cheng, Huan Wang, Ketao Wu, Yin Zhu, Nonghua Lü · 2018 · Clinics and Research in Hepatology and Gastroenterology
49. Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study
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50. Human genetics of steatotic liver disease: insights into insulin resistance and lipid metabolism
    Rosellina Margherita Mancina, Luca V. C. Valenti, Stefano Romeo · 2025 · Nature Metabolism
51. Impaired Insulin Clearance as the Initial Regulator of Obesity-Associated Hyperinsulinemia: Novel Insight Into the Underlying Mechanism Based on Serum Bile Acid Profiles
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52. Nonalcoholic Fatty Liver Disease and Type 2 Diabetes in Obese Children
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53. Phosphoethanolamine cytidylyltransferase ameliorates mitochondrial function and apoptosis in hepatocytes in T2DM in vitro
    Hu Xu, Weizu Li, Lei Huang, Xinyu He, Bei Xu, Xueqing He, Wentong Chen, Yaoxing Wang, Wenjun Xu, Sheng Wang et al. · 2023 · Journal of Lipid Research
54. Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with Type 2 diabetes with and without fatty liver
    David P. Macfarlane, Peter Johann Raubenheimer, T. Preston, Calum D. Gray, Mark E. Bastin, Ian Marshall, John Peter Iredale, Ruth Andrew, BR Walker · 2014 · American Journal of Physiology-Gastrointestinal and Liver Physiology
55. Duodenal-Jejunal Bypass Surgery Suppresses Hepatic De Novo Lipogenesis and Alleviates Liver Fat Accumulation in a Diabetic Rat Model
    Haifeng Han, Chun-Xiao Hu, Lei Wang, Guangyong Zhang, Shaozhuang Liu, Feng Li, Dong Sun, Sanyuan Hu · 2014 · Obesity Surgery
56. CB1R antagonist increases hepatic insulin clearance in fat-fed dogs likely via upregulation of liver adiponectin receptors
    Morvarid Kabir, Malini S. Iyer, Joyce M. Richey, Orison O. Woolcott, Isaac Asare Bediako, Qiang Wu, Stella P. Kim, Darko Stefanovski, Cathryn M. Kolka, Isabel R. Hsu et al. · 2015 · American Journal of Physiology-Endocrinology and Metabolism
57. Role of Insulin Resistance and Diabetes in the Pathogenesis and Treatment of Nonalcoholic Fatty Liver Disease
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58. Clinical physiology of NAFLD: a critical overview of pathogenesis and treatment
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59. Liver Fat Content, Evaluated through Semi-Quantitative Ultrasound Measurement, Is Associated with Impaired Glucose Profiles: A Community-Based Study in Chinese
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60. Dai-Zong-Fang, A Traditional Chinese Herbal Formula, Ameliorates Insulin Resistance in db/db Mice
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61. Insulin Resistance in Type 2 Diabetes
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62. Novel drugs in familial combined hyperlipidemia: lessons from type 2 diabetes mellitus
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63. Ectopic fat, insulin resistance and metabolic disease in non-obese Asians: investigating metabolic gradation.
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64. Association between Nonalcoholic Fatty Liver Disease and Carotid Artery Disease in a Community-Based Chinese Population
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65. Higher serum vitamin A is associated with a worsened progression of non-alcoholic fatty liver disease in adults: a prospective study
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66. Body Fat Distribution Contributes to Defining the Relationship between Insulin Resistance and Obesity in Human Diseases
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67. Role of fatty liver in the association between obesity and reduced hepatic insulin clearance
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68. Ideal cardiovascular health associated with fatty liver: Results from a multi-ethnic survey
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69. Molecular imaging of diabetes and diabetic complications: Beyond pancreatic β-cell targeting
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70. Independent association of liver fat accumulation with insulin resistance
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71. Pharmacokinetic/Pharmacodynamic Modeling of Glucose Clamp Effects of Inhaled and Subcutaneous Insulin in Healthy Volunteers and Diabetic Patients
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72. Metformin and Diammonium Glycyrrhizinate Enteric-Coated Capsule versus Metformin Alone versus Diammonium Glycyrrhizinate Enteric-Coated Capsule Alone in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus
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73. Ethnic differences in intrahepatic lipid and its association with hepatic insulin sensitivity and insulin clearance between men of black and white ethnicity with early type 2 diabetes
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85. Adipose tissue insulin resistance exacerbates liver inflammation and fibrosis in a diet-induced NASH model
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86. Steatosis degree, measured by morphometry, is linked to other liver lesions and metabolic syndrome components in patients with NAFLD
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87. T2 determination of the J‐coupled methyl protons of lipids: In vivo ilustration with tibial bone marrow at 3 T
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88. The Role of Visceral Adipose Tissue in the Pathogenesis of Non-alcoholic Fatty Liver Disease
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91. Nigella sativa Oil and Chromium Picolinate Ameliorate Fructose-Induced Hyperinsulinemia by Enhancing Insulin Signaling and Suppressing Insulin-Degrading Enzyme in Male Rats
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92. Sex and ethnic differences in the cardiovascular complications of type 2 diabetes
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94. A Systematic Review of Beta Cell Function in Adults of Black African Ethnicity
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95. Ethnicity-specific alterations of plasma and hepatic lipidomic profiles are related to high NAFLD rate and severity in Hispanic Americans, a pilot study
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97. Insights in diabetes: Molecular mechanisms-Protectin DX, an anti-inflammatory and a stimulator of inflammation resolution metabolite of docosahexaenoic acid, protects against the development of streptozotocin-induced type 1 and type 2 diabetes mellitus in male Swiss albino mice
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98. Long echo time proton magnetic resonance spectroscopy for estimating relative measures of lipid unsaturation at 3 T
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99. Abnormalities in the Metabolism of Fatty Acids and Triacylglycerols in the Liver of the Goto‐Kakizaki Rat: A Model for Non‐Obese Type 2 Diabetes
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100. Endogenously released GIP reduces and GLP-1 increases hepatic insulin extraction
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