The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Biology and Treatment of Eosinophilic Esophagitis
Open accessAbstract
Eosinophilic esophagitis, a recently recognized and growing clinical disorder over the past decade, is characterized by antigen-driven eosinophil accumulation in the esophagus. Symptoms frequently mimic those of gastroesophageal reflux disease (GERD) but the two diseases are quite distinct in terms of their histopathology, genetic signature, response to therapy, hereditary risk and association with allergy. Disease pathogenesis involves the interplay of external and genetic factors, particularly food antigens and the eosinophil chemoattractant eotaxin-3, respectively. Transcript signatures and animal models have uncovered the importance of adaptive T cell immunity involving IL-5 and IL-13 elicited esophageal epithelial cell responses. Notably, symptoms, dysregulated esophageal gene expression and pathology are largely reversible following reduction of specific food antigen exposure, as well as anti-inflammatory therapy, but chronic treatment is necessary to prevent relapse. As such, eosinophilic esophagitis is a disease with the unique features of chronic esophagitis, atopy, immune sensitization to oral antigens, reversibility and familial association.
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Cites
14 Years of Eosinophilic Esophagitis: Clinical Features and Prognosis
Spergel, J. M., Brown‐Whitehorn, T. F., Beausoleil, J. L., Franciosi, J., Shuker, M., Verma, R., & Liacouras, C. A. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181788282 · Cited by 467
Filaggrin in atopic dermatitis
O'Regan, G. M., Sandilands, A., McLean, W. H. I., & Irvine, A. D. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.08.002 · Cited by 350
Pediatric patients with eosinophilic esophagitis: An 8-year follow-up
Assa'ad, A. H., Putnam, P. E., Collins, M. H., Akers, R. M., Jameson, S. C., Kirby, C. L., Buckmeier, B. K., Bullock, J. Z., Collier, A. R., Konikoff, M. R., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.10.044 · Cited by 331
Self-citationTh2 Cytokines Act on S100/A11 to Downregulate Keratinocyte Differentiation
Howell, M. D., Fairchild, H. R., Kim, B. E., Bin, L., Boguniewicz, M., Redzic, J. S., Hansen, K. C., & Leung, D. Y. M. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.74 · Cited by 224
Seasonal Distribution in Newly Diagnosed Cases of Eosinophilic Esophagitis in Adults
Almansa, C., Krishna, M., Buchner, A. M., Ghabril, M. S., Talley, N., DeVault, K. R., Wolfsen, H., Raimondo, M., Guarderas, J. C., & Achem, S. R. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.169 · Cited by 210
Cited by
Boyce, J. A., Assa'ad, A., Burks, A. W., Jones, S. M., Sampson, H. A., Wood, R. A., Plaut, M., Cooper, S. F., Fenton, M. J., Arshad, S. H., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.008 · Cited by 2,350
Food allergy: A practice parameter update—2014
Sampson, H. A., Aceves, S., Bock, S. A., James, J., Jones, S., Lang, D., Nadeau, K., Nowak-Wegrzyn, A., Oppenheimer, J., Perry, T. T., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.05.013 · Cited by 845
Gonsalves, N., Yang, G., Doerfler, B., Ritz, S., Ditto, A. M., & Hirano, I. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.03.001 · Cited by 616
for the SIF-AIGO-FIMMG Group, Scarpignato, C., on behalf of the Italian Society of Pharmacology, T. I. A. O. H. G., Gatta, L., Zullo, A., & Blandizzi, C. (2016) · BMC Medicine · doi:10.1186/s12916-016-0718-z · Cited by 469
Valenta, R., Hochwallner, H., Linhart, B., & Pahr, S. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.02.006 · Cited by 277
Metadata
- Authors
- Rothenberg, M. E.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 137
- Issue
- 4
- Pages
- 1238-1249
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2071962822
- Cited by
- 285
- References
- 5
- FWCI
- 32.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
