A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells

Cited by (241)

Items 101–200 of 241

  1. Amelioration of non-alcoholic fatty liver disease with NPC1L1-targeted IgY or n-3 polyunsaturated fatty acids in mice
    Jin-Sik Bae, Jong Min Park, Junghoon Lee, Byung‐Chul Oh, Sang‐Ho Jang, Yun Bin Lee, Young-Min Han, Chan-Young Ock, Ji-Young Cha, Ki‐Baik Hahm · 2016 · Metabolism
  2. A Metabonomics Approach to Drug Toxicology in Liver Disease and its Application in Traditional Chinese Medicine
    Guangyue Su, Haifeng Wang, Jiao Bai, Gang Chen, Yue‐Hu Pei · 2019 · Current Drug Metabolism
  3. Rifaximin Prevents T-Lymphocytes and Macrophages Infiltration in Cerebellum and Restores Motor Incoordination in Rats with Mild Liver Damage
    Tiziano Balzano, Paola Leone, Gergana Mincheva, Mari Carmen Castro, Lestteriel Reyes, Chusé Ramón, Michele Malaguarnera, Marta Llansola, Vicente Felipo · 2021 · Biomedicines
  4. Dysregulation of Kupffer Cells/Macrophages and Natural Killer T Cells in Steatohepatitis in LXRα Knockout Male Mice
    Kaori Endo‐Umeda, Hiroyuki Nakashima, Naoki Umeda, Shuhji Seki, Makoto Makishima · 2018 · Endocrinology
  5. Mechanisms of liver fibrosis in metabolic syndrome
    Mehal, Wajahat · 2023 · eGastroenterology
  6. Dietary Cholic Acid Exacerbates Liver Fibrosis in NASH Model of Sprague–Dawley Rats Fed a High-Fat and High-Cholesterol Diet
    Mayuko Ichimura‐Shimizu, Shiro Watanabe, Yuka Kashirajima, Ami Nagatomo, Hitomi Wada, Koichi Tsuneyama, Katsuhisa Omagari · 2022 · International Journal of Molecular Sciences
  7. High Fat Diet Causes Renal Fibrosis in LDLr-null Mice Through MAPK-NF-κB Pathway Mediated by Ox-LDL
    Yao Dai, Philip Palade, Xianwei Wang, Federico Mercanti, Zufeng Ding, Dongsheng Dai, Jawahar L. Mehta · 2013 · Journal of Cardiovascular Pharmacology
  8. Prevention of hepatic fibrosis with liver microsomal triglyceride transfer protein deletion in liver fatty acid binding protein null mice
    Elizabeth P. Newberry, Yan Xie, Susan Kennedy, Mark J. Graham, Rosanne M. Crooke, Hui Jiang, Anping Chen, Daniel S. Ory, Nicholas O. Davidson · 2016 · Hepatology
  9. Fibrogenic Pathways in Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD)
    Pallavi Subramanian, Jochen Hampe, Frank Tacke, Triantafyllos Chavakis · 2022 · International Journal of Molecular Sciences
  10. Cholesterol accumulation in hepatocytes mediates IRE1/p38 branch of endoplasmic reticulum stress to promote nonalcoholic steatohepatitis
    Erdi Sözen, Tuğçe Demirel-Yalçıner, Dyana Sari, Nesrin Kartal Özer · 2022 · Free Radical Biology and Medicine
  11. Dietary Cholesterol Intake Is Associated With Progression of Liver Disease in Patients With Chronic Hepatitis C: Analysis of the Hepatitis C Antiviral Long-term Treatment Against Cirrhosis Trial
    Lei Yu, Chihiro Morishima, George N. Ioannou · 2013 · Clinical Gastroenterology and Hepatology
  12. Steatohepatitis in laboratory opossums exhibiting a high lipemic response to dietary cholesterol and fat
    Jeannie Chan, Francis E. Sharkey, Rampratap S. Kushwaha, Jane F. VandeBerg, John L. VandeBerg · 2012 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  13. Serum miR-379 expression is related to the development and progression of hypercholesterolemia in non-alcoholic fatty liver disease
    Kinya Okamoto, Masahiko Koda, Toshiaki Okamoto, Takumi Onoyama, Kenichi Miyoshi, Manabu Kishina, Tomomitsu Matono, Jun Kato, Shiho Tokunaga, Takaaki Sugihara et al. · 2020 · PLoS ONE
  14. Expression and Function of BMP and Activin Membrane-Bound Inhibitor (BAMBI) in Chronic Liver Diseases and Hepatocellular Carcinoma
    Florian Weber, Oliver Treeck, Patricia Mester, Christa Buechler · 2023 · International Journal of Molecular Sciences
  15. PNPLA3-I148M Variant Promotes the Progression of Liver Fibrosis by Inducing Mitochondrial Dysfunction
    Yusong Gou, Lifei Wang, Jinhan Zhao, Xiaoyi Xu, Hangfei Xu, Fang Xi Xie, Yanjun Wang, Yingmei Feng, Jing Zhang, Yang Zhang · 2023 · International Journal of Molecular Sciences
  16. Expression and distribution patterns of Mas-related gene receptor subtypes A–H in the mouse intestine: inflammation-induced changes
    Leela Rani Avula, Roeland Buckinx, Herman W. Favoreel, Eric Cox, Dirk Adriaensen, Luc Van Nassauw, Jean‐Pierre Timmermans · 2013 · Histochemistry and Cell Biology
  17. Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation
    Yuh‐Ching Twu, Tzong‐Shyuan Lee, Yun‐Lian Lin, Shih‐Ming Hsu, Yuan-Hsi Wang, Chia-Yu Liao, Chung-Kwe Wang, Yu‐Chih Liang, Yi‐Jen Liao · 2016 · International Journal of Molecular Sciences
  18. The roles of Toll-like receptor 4 in the pathogenesis of pathogen-associated biliary fibrosis caused by Clonorchis sinensis
    Chao Yan, Bo Li, Fang Fan, Ying Du, Rui Ma, Xiao-Dan Cheng, Xiangyang Li, Bo Zhang, Qian Yu, Yugang Wang et al. · 2017 · Scientific Reports
  19. Niemann-Pick Type C2 Protein Regulates Free Cholesterol Accumulation and Influences Hepatic Stellate Cell Proliferation and Mitochondrial Respiration Function
    Yuan-Hsi Wang, Yuh‐Ching Twu, Chung-Kwe Wang, Fu-Zhen Lin, Chun-Ya Lee, Yi‐Jen Liao · 2018 · International Journal of Molecular Sciences
  20. A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice
    Xiaojing Wang, Naoki Tanaka, Xiao Hu, Takefumi Kimura, Lu Yu, Fangping Jia, Yoshiko Sato, Jun Nakayama, Kyoji Moriya, Kazuhiko Koike et al. · 2019 · Archives of Toxicology
  21. Fibrosis and Hepatocarcinogenesis: Role of Gene-Environment Interactions in Liver Disease Progression
    Anindita Banerjee, Patrizia Farci · 2024 · International Journal of Molecular Sciences
  22. Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies
    Fangping Jia, Xiao Hu, Takefumi Kimura, Naoki Tanaka · 2021 · International Journal of Molecular Sciences
  23. ChemPert: mapping between chemical perturbation and transcriptional response for non-cancer cells
    Menglin Zheng, Satoshi Okawa, Miren Bravo, Fei Chen, Maria Luz Martínez‐Chantar, Antonio del Sol · 2022 · Nucleic Acids Research
  24. Role of FDFT 1 polymorphism for fibrosis progression in patients with chronic hepatitis C
    Albert Friedrich Stättermayer, Karoline Rutter, Sandra Beinhardt, Fritz Wrba, Thomas Matthias Scherzer, Michael Straßer, Harald Hofer, Petra Steindl‐Munda, Michael A Trauner, Péter Ferenci · 2013 · Liver International
  25. Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH
    Gregory R. Steinberg, Jaya Gautam, James Lally, Russta Fayyazi, E. Grasset, Dipankar Bhattacharya, Gio Fidelito, Elham Ahmadi, Logan K. Townsend, Battsetseg Batchuluun et al. · 2026 · Cell Metabolism
  26. Cellular heterogeneity and plasticity during NAFLD progression
    Hyunju Park, Juyong Choi, Hyun-Mi Kim, Da-Yeon Yang, Tae Hyeon An, Eun‐Woo Lee, Baek‐Soo Han, Sang Chul Lee, Won Kon Kim, Kwang‐Hee Bae et al. · 2023 · Frontiers in Molecular Biosciences
  27. Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet
    Hyunju Kang, P.B. Tirupathi Pichiah, R Abinaya, Hee‐Sook Sohn, Youn‐Soo Cha · 2016 · Food Science and Biotechnology
  28. Mechanisms of hepatic stellate cell activation as a therapeutic target for the treatment of non-alcoholic steatohepatitis
    Takuma Tsuchida · 2019 · Folia Pharmacologica Japonica
  29. A Novel Sialoglycopeptide from Gadus morhua Eggs Prevents Liver Fibrosis Induced by CCl 4 via Downregulating FXR/FGF15 and TLR4/TGF-β/Smad Pathways
    Hao Yue, Weizhen Cai, Yanqi Li, Xiaoxuan Feng, Ping Dong, Changhu Xue, Jingfeng Wang · 2021 · Journal of Agricultural and Food Chemistry
  30. Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol
    Xing-Zi Li, Shi‐You Jiang, Guoqiang Li, Qian-Ru Jiang, Juewan Li, Chenchen Li, Yu-Qin Han, Bao‐Liang Song, Xinran Ma, Wei Qi et al. · 2022 · European Journal of Medicinal Chemistry
  31. Is hepatic lipogenesis fundamental for NAFLD/NASH? A focus on the nuclear receptor coactivator PGC-1β
    Simon Ducheix, Maria Carmela Vegliante, Gaetano Villani, Nicola Napoli, Carlo Sabbà, Antonio Moschetta · 2016 · Cellular and Molecular Life Sciences
  32. Ethanol and High Cholesterol Diet Causes Severe Steatohepatitis and Early Liver Fibrosis in Mice
    Yasodha Krishnasamy, Venkat K. Ramshesh, Monika Beck Gooz, Rick G. Schnellmann, John J. Lemasters, Zhi Zhong · 2016 · PLoS ONE
  33. Metabolic Sparks in the Liver: Metabolic and Epigenetic Reprogramming in Hepatic Stellate Cells Activation and Its Implications for Human Metabolic Diseases
    Yeon Jin Roh, Hyeonki Kim, Dong Wook Choi · 2025 · Diabetes & Metabolism Journal
  34. Free Cholesterol‐Induced Liver Injury in Non‐Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I
    Jia‐Wen Shou, Juncai Ma, Xuchu Wang, Xiaoxiao Li, Shu‐Cheng Chen, Byung‐Ho Kang, Pang‐Chui Shaw · 2024 · Advanced Science
  35. Alcohol-induced epigenetic changes prevent fibrosis resolution after alcohol cessation in miceresolution
    Michael P. Schonfeld, Maura F. O’Neil, Steven A. Weinman, Irina Tikhanovich · 2023 · Hepatology
  36. Drug Delivery with Hyaluronic Acid-Coated Polymeric Micelles in Liver Fibrosis Therapy
    Yuta Yoshizaki, Manami Yamasaki, Takuya Nagata, Kengo Suzuki, Rio Yamada, Takuma Kato, Nobuo Murase, Akinori Kuzuya, Akira Asai, Kazuhide Higuchi et al. · 2023 · ACS Biomaterials Science & Engineering
  37. Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats
    Masaki Ishikawa, Kosuke Saito, Hiroshi Yamada, Noriyuki Nakatsu, Keiko Maekawa, Yoshiro Saito · 2016 · Lipids in Health and Disease
  38. Elucidating Potential Profibrotic Mechanisms of Emerging Biomarkers for Early Prognosis of Hepatic Fibrosis
    Mishghan Zehra, James C Curry, Sneha S. Pillai, Hari Vishal Lakhani, Cory E. Edwards, Komal Sodhi · 2020 · International Journal of Molecular Sciences
  39. Vessel wall BAMBI contributes to hemostasis and thrombus stability
    Isabelle I. Salles‐Crawley, James H. Monkman, Josefin Ahnström, David A. Lane, James T. B. Crawley · 2014 · Blood
  40. Stellate Cells and Hepatic Fibrosis
    Daisuke Hasegawa, Michael C. Wallace, Scott L. Friedman · 2015 · Elsevier eBooks
  41. Exploring Fibrosis Pathophysiology in Lean and Obese Metabolic-Associated Fatty Liver Disease: An In-Depth Comparison
    Milena N. Vesković, Milka Pejović, Nikola Šutulović, Dragan Hrnčić, Aleksandra Rašić-Marković, Olivera P. Stanojlović, Dušan R. Mladenović · 2024 · International Journal of Molecular Sciences
  42. Dietary fat, cholesterol, and cholic acid affect the histopathologic severity of nonalcoholic steatohepatitis in Sprague-Dawley rats
    Ayumi Fukuda, Marin Sasao, Eri Asakawa, Sumire Narita, Mei Hisano, Kazuhito Suruga, Mayuko Ichimura‐Shimizu, Koichi Tsuneyama, Kazunari Tanaka, Katsuhisa Omagari · 2019 · Pathology - Research and Practice
  43. Crosstalk in extrahepatic and hepatic system in NAFLD / NASH
    Yiliang Duan, Yan Zhu Yang, Shuqiang Zhao, Yuesong Bai, Wenbing Yao, Xiangdong Gao, Jun Yin · 2024 · Liver International
  44. Unraveling the hepatic stellate cells mediated mechanisms in aging's influence on liver fibrosis
    Reham M. Wahid, Nancy Husseiny Hassan, Walaa Mohamed Samy, Amina A. Abdelhadi, Sara Fouad Saadawy, Sherein F. El-sayed, Sara Gamal Seada, Sara Refaee Abdo Mohamed · 2024 · Scientific Reports
  45. Impact of mitochondrial lipid alterations on liver disease mechanisms and progression
    Laura Fàbrega, José Carlos Fernández-Checa, Laura Conde de la Rosa, Carmen García‐Ruiz · 2024 · Exploration of Digestive Diseases
  46. Nonalcoholic fatty liver disease: from lipid profile to treatment
    Kouichi Miura, Hirohide Ohnishi · 2012 · Clinical Journal of Gastroenterology
  47. Angiopoietin‐like protein 4 deficiency augments liver fibrosis in liver diseases such as nonalcoholic steatohepatitis in mice through enhanced free cholesterol accumulation in hepatic stellate cells
    Toshiaki Teratani, Kengo Tomita, Akinori Wada, Nao Sugihara, Masaaki Higashiyama, Kenichi Inaba, Kazuki Horiuchi, Yoshinori Hanawa, Shin Nishii, Akinori Mizoguchi et al. · 2020 · Hepatology Research
  48. Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitis
    Miyagawa, Sawa, Horie, Takahiro, Nishino, Tomohiro, Koyama, Satoshi, Watanabe, Toshimitsu, Baba, Osamu, Yamasaki, Tomohiro, Sowa, Naoya, Otani, Chiharu, Matsushita, Kazuki et al. · 2023 · Life Science Alliance
  49. Immune Checkpoints and the Immunology of Liver Fibrosis
    Ioannis Tsomidis, Argyro Voumvouraki, Elias Kouroumalis · 2025 · Livers
  50. Effects of Nongxiangxing baijiu (Chinese liquor) on mild alcoholic liver injury revealed by non-target metabolomics using ultra-performance liquid chromatography quadrupole-time-of-flight mass spectrometry
    Cuifang Wu, Xiaofan Xing, Guoying Liu, Die Su, Anjun Li, Shuangying Gui, Wei Lü, Juan Boo Liang · 2022 · Journal of Bioscience and Bioengineering
  51. Ferroptosis in liver fibrosis and its potential intervention strategy
    Wanchun Zhu, Lihong Fu, Yu Cui, Yiwen Tang, Kun Liu, Lei Shi, Yueqiu Gao, Man Li, Lingying Huang · 2025 · Cell Biology and Toxicology
  52. Notoginsenoside R1 targets PPAR-γ to inhibit hepatic stellate cell activation and ameliorates liver fibrosis
    Cheng Guo, Linying Lai, Boyu Ma, Qian Huang, Zhirong Wang · 2024 · Experimental Cell Research
  53. Disruption of cholesterol homeostasis triggers NLRP3-cGAS-STING axis-dependent hepatic fibrosis and honokiol intervention effects
    Zhilei Wang, Jingwen Liu, Yu Mou, Xianglu Zhou, Wenhao Liao, Yuchen Li, Yong Liu, Jianyuan Tang · 2025 · Phytomedicine
  54. Playing Jekyll and Hyde—The Dual Role of Lipids in Fatty Liver Disease
    Martijn R. Molenaar, Louis C. Penning, J. Bernd Helms · 2020 · Cells
  55. Heukcha, naturally post‐fermented green tea extract, ameliorates diet‐induced hypercholesterolemia and NAFLD in hamster
    Minji Kang, Ee Hyun Kim, Jeewon Jeong, Hunjoo Ha · 2021 · Journal of Food Science
  56. Impact of Sex and Gender on Clinical Management of Patients with Advanced Chronic Liver Disease and Type 2 Diabetes
    Anna Licata, Giuseppina Tiziana Russo, Annalisa Giandalia, Marcella Cammilleri, Clelia Asero, Irene Cacciola · 2023 · Journal of Personalized Medicine
  57. Effects of multiple metals exposure on abnormal liver function: The mediating role of low-density lipoprotein cholesterol
    Xu Han, Ziquan Lv, Meian He, Jinquan Cheng, Yanwei Zhang, Tian Wang, Jiaxin Chen, Yuewei Liu, Dongsheng Hu, Xuli Wu et al. · 2024 · Ecotoxicology and Environmental Safety
  58. Female C57BL/6 mice exhibit protection against nonalcoholic fatty liver disease and diabesity accompanied by differential regulation of hepatic lipocalin prostaglandin D2 synthase
    Md Asrarul Islam, Rhema Khairnar, Joshua S. Fleishman, Sandra E. Reznik, Louis Ragolia, Shruthi Gobbooru, Sunil Kumar · 2024 · Molecular and Cellular Endocrinology
  59. Zoledronic acid prevents the hepatic changes associated with high fat diet in rats; the potential role of mevalonic acid pathway in nonalcoholic steatohepatitis
    Reham Hussein Mohamed, Maha Tarek, Ghada Galal Hamam, Samar F. Ezzat · 2019 · European Journal of Pharmacology
  60. Beneficial Effects of Moderate Hepatic Activin A Expression on Metabolic Pathways, Inflammation, and Atherosclerosis
    Huan Liu, Margaret H. Hastings, Robert R. Kitchen, Chunyang Xiao, Justin Ralph Baldovino Guerra, Alexandra Kuznetsov, Anthony Rosenzweig · 2022 · Arteriosclerosis Thrombosis and Vascular Biology
  61. Ecballium elaterium improved stimulatory effects of tissue-resident NK cells and ameliorated liver fibrosis in a thioacetamide mice model
    Mustafa A Ghanim, Johnny Amer, Ahmad Salhab, Nidal Amin Jaradat · 2022 · Biomedicine & Pharmacotherapy
  62. Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High-Fat, High-Fructose, High-Cholesterol Diet Mouse Model
    Phoebe Ohene-Marfo, Hoang Van M. Nguyen, Sabira Mohammed, Nidheesh Thadathil, Albert Tran, Evan H. Nicklas, Dawei Wang, Ramasamy Selvarani, Jacob W. Farriester, Rohan Varshney et al. · 2024 · International Journal of Molecular Sciences
  63. The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and hepatic steatosis and liver fibrosis among US adults based on NHANES
    Baoyu Li, Yuwei Liu, Xiaorong Ma, Xiaoyan Guo · 2025 · Scientific Reports
  64. The Spatial Transcriptional Activity of Hepatic TCF7L2 Regulates Zonated Metabolic Pathways that Contribute to Liver Fibrosis
    Iriscilla Ayala, Skanda K. Hebbale, Juho Mononen, Madelaine C. Brearley-Sholto, Chris E. Shannon, Ivan Valdez, Marcel J. Fourcaudot, Terry M. Bakewell, Anna Zagorska, Giovanna Romero et al. · 2025 · Nature Communications
  65. Nonalcoholic Fatty Liver Disease Patients Exhibit Reduced CD47 and Increased Sphingosine, Cholesterol, and Monocyte Chemoattractant Protein-1 Levels in the Erythrocyte Membranes
    Charalampos Papadopoulos, Eleftheria Spourita, Konstantinos Mimidis, George C. Kolios, Loannis Tentes, Konstantinos P. Anagnostopoulos · 2022 · Metabolic Syndrome and Related Disorders
  66. Elevated cholesterol levels have a poor prognosis in a cholestasis scenario
    Natalia Nuño‐Lámbarri, Varenka J. Barbero-Becerra, Misael Uribe, Norberto Carlos Chávez-Tapia · 2016 · Journal of Biochemical and Molecular Toxicology
  67. Liver Fibrosis Associated with Potential Vinyl Chloride and Ethylene Dichloride Exposure from the Petrochemical Industry
    Tzu‐Hsuen Yuan, Junlin Chen, Ruei‐Hao Shie, Yen‐Po Yeh, Yi‐Hsuan Chen, Chang‐Chuan Chan · 2020 · The Science of The Total Environment
  68. Extracellular vesicles from mesenchymal stem cells alter gut microbiota and improve neuroinflammation and motor impairment in rats with mild liver damage
    Gergana Mincheva, Vicente Felipo, Victoria Moreno‐Manzano, Alfonso Benítez‐Páez, Marta Llansola · 2024 · Neurotherapeutics
  69. CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion
    Yuji Nakamura, Takanori Kanai∥, Keita Saeki, Miho Takabe, Junichiro Irie, Jun Miyoshi, Yohei Mikami, Toshiaki Teratani, Takahiro Suzuki, Naoteru Miyata et al. · 2013 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  70. Establishment of Novel Mouse Model of Dietary NASH Rapidly Progressing into Liver Cirrhosis and Tumors
    Qianqian Zheng, Masaya Kawaguchi, Hayato Mikami, Pan Diao, Xuguang Zhang, Zhe Zhang, Takero Nakajima, Takanobu Iwadare, Takefumi Kimura, Jun Nakayama et al. · 2023 · Cancers
  71. Immune microenvironment changes of liver cirrhosis: emerging role of mesenchymal stromal cells
    Qiuyun Yi, Jinxian Yang, Ying Wu, Ying Wang, Qiqi Cao, Wen Wen · 2023 · Frontiers in Immunology
  72. Pathophysiological Characteristics of Non-Alcoholic Steatohepatitis-Like Changes in Cholesterol-Loaded Type 2 Diabetic Rats
    Yasufumi Toriniwa, M. MURAMATSU, Y. ISHII, E. RIYA, K Miyajima, S. OHSHIDA, Kanae Kitatani, Susumu Takekoshi, Tohru Matsui, S. KUME et al. · 2018 · Physiological Research
  73. Comparison of the effects of cholesterol, palmitic acid, and glucose on activation of human hepatic stellate cells to induce liver fibrosis
    Ghorban Mohammadzadeh, Reza Afarin, Samaneh Salehipour Bavarsad, Fereshteh Aslani, Shahla Asadi Zadeh, Elham Shakerian · 2022 · Journal of Diabetes & Metabolic Disorders
  74. Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD): data from the NHANES III (1988–1994)
    Ying Zhang, Pengyu Luo, Yu-Na Tang, Jing Wang, Shuai Gao, Yu‐Chen Fan, Kai Wang · 2025 · Nutrition & Metabolism
  75. 27-Hydroxycholesterol induces liver fibrosis via down-regulation of trimethylation of histone H3 at lysine 27 by activating oxidative stress; effect of nutrient interventions
    Kai Jiao, Keke Yang, Jie Wang, Yifan Ni, Chunyan Hu, Jiao Liu, Ming Zhou, Jin Zheng, Zhong Li · 2023 · Free Radical Biology and Medicine
  76. Cholesterol: The driving force behind the remodeling of tumor microenvironment in colorectal cancer
    Ke Wang, Yuanyuan Zhang, Chengshuai Si, Yuepeng Cao, Peng Shao, Pei Zhang, Nannan Wang, Guoqing Su, Jinghang Qian, Yang Liu · 2024 · Heliyon
  77. Harnessing nuclear receptors to modulate hepatic stellate cell activation for liver fibrosis resolution
    Yaxin Sun, Xiaoyan Yuan, Zhenhua Hu, Yuanyuan Li · 2024 · Biochemical Pharmacology
  78. Vegetal oil-based ketogenic diet improves inflammation and fibrosis in experimental metabolic dysfunction-associated steatohepatitis
    Alessia Provera, N. N. Ramavath, L. L. Gadipudi, C. Vecchio, M. Caputo, A. Antonioli, S. Tini, A. N. Sheferaw, S. Reano, N. Filigheddu et al. · 2025 · Frontiers in Immunology
  79. The Ability of Different Ketohexoses to Alter Apo‐A‐I Structure and Function In Vitro and to Induce Hepatosteatosis, Oxidative Stress, and Impaired Plasma Lipid Profile in Hyperlipidemic Zebrafish
    Dhananjay Yadav, Suk‐Jeong Kim, Myung Ae Bae, Jae‐Ryong Kim, Kyung‐Hyun Cho · 2018 · Oxidative Medicine and Cellular Longevity
  80. Delphinidin or α‐amyrin attenuated liver steatosis and metabolic disarrangement in rats fed a high‐fat diet
    Bassam Mohamed Ali, Eman Maher Elbaz, Asmaa K. Al‐Mokaddem, Soad Z. El‐Emam, Magdy M. Awny · 2024 · BioFactors
  81. Immune and metabolic cross-links in the pathogenesis of comorbid non-alcoholic fatty liver disease
    Stanislav Nikolaevich Kotlyarov · 2023 · World Journal of Gastroenterology
  82. Effects of exosomes of mesenchymal stem cells on cholesterol-induced hepatic fibrogenesis.
    Mojtaba Rashidi, Emad Matour, Sajad Monjezi, Shahla Asadi Zadeh, Elham Shakerian, Sahar Sabahy, Reza Afarin · 2023 · PubMed Central
  83. Beneficial effects of diacerein on adipokines and pro-inflammatory cytokines involved in diet-induced nonalcoholic steatohepatitis in rats
    Omaima M. Abd Allah · 2017 · International Journal of Basic & Clinical Pharmacology
  84. Changes in liver lipidomics associated with sodium cholate-induced liver injury and its prevention by boiogito, a Japanese herbal medicine, in mice
    Shiro Watanabe, Kyosuke Fujita, Koichi Tsuneyama, Mitsuhiko Nose · 2015 · Traditional & Kampo Medicine
  85. Novel Choline-Deficient and 0.1%-Methionine-Added High-Fat Diet Induces Burned-Out Metabolic-Dysfunction-Associated Steatohepatitis with Inflammation by Rapid Immune Cell Infiltration on Male Mice
    Takatoshi Sakaguchi, Yasuharu Nagahama, Nanako Hamada, Shailendra Kumar Singh, Hayato Mikami, Kazuhiko Maeda, Shizuo Akira · 2024 · Nutrients
  86. Macronutrient Modulation in Metabolic Dysfunction-Associated Steatotic Liver Disease—the Molecular Role of Fatty Acids compared with Sugars in Human Metabolism and Disease Progression
    Sinéad M. Mullin, Aidan J Kelly, Méabh B. Ní Chathail, Suzanne Norris, Chris E. Shannon, Helen M. Roche · 2025 · Advances in Nutrition
  87. Efficacy Assessment of Five Policosanol Brands and Damage to Vital Organs in Hyperlipidemic Zebrafish by Six-Week Supplementation: Highlighting the Toxicity of Red Yeast Rice and Safety of Cuban Policosanol (Raydel®)
    Kyung‐Hyun Cho, Ashutosh Bahuguna, Ji Eun Kim, Sang‐Hyuk Lee · 2024 · Pharmaceuticals
  88. Combination of Policosanol (Raydel®) and Atorvastatin Improve High-Density Lipoproteins and Antioxidant Abilities to Protect Vital Organs and Fertility in Hyperlipidemic/Hyperglycemic Zebrafish
    Kyung‐Hyun Cho, Ashutosh Bahuguna, Ji-Eun Kim, Sang Hyuk Lee, Yunki Lee, Cheolmin Jeon, Seung Hee Baek, Krismala Djayanti · 2026 · Pharmaceuticals
  89. The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease
    Yuan Dong, Yuejie Zhang, Yingmei Feng, Wei An · 2022 · Frontiers in Pharmacology
  90. Emerging Concepts on the Pathogenesis of Non‐Alcoholic Steatohepatitis (NASH)
    Isabelle Anne Leclercq · 2013 · Wiley eBooks
  91. Beyond obesity: Is cholesterol‐induced liver injury the cause of non‐alcoholic steatohepatitis?
    George N. Ioannou · 2012 · Journal of Gastroenterology and Hepatology
  92. From mechanisms to anti-fibrotic drugs in hepatic stellate cell research: a global bibliometric analysis with patent and clinical perspectives (2000–2025)
    Xiaowen Mao, Peng Chen, Palidan Wubur, Yi Liu, Yuan Zhao, Siwei Zhang, Na Guan, Bin Li · 2025 · Frontiers in Pharmacology
  93. Oxymatrine impedes Alzheimer’s progression via the attenuation of hypercholesterolemia and fibrosis
    Ashmita Das, Rahul Manna, Durlav Chowdhury, D. P. Sharma, Surendra Haribhau Bodakhe · 2025 · Metabolic Brain Disease
  94. The Transforming Growth Factor-Beta (TGF-β) in Liver Fibrosis
    Isabel Fabregat, Patricia Sancho · 2013 · Springer eBooks
  95. NAFLD-Associated Hepatocellular Carcinoma: a Threat to Patients with Metabolic Disorders
    A. Sasdelli, L. Brodosi, G. Marchesini · 2016 · Current Hepatology Reports
  96. Longitudinal evaluation of liver stiffness reveals hepatic cholesterol as the determinant of fibrosis progression in mice
    Na Young Lee, Ja Hyun Koo · 2024 · Life Sciences
  97. Mechanism and therapeutic potential of liver injury induced by cholesterol-associated proteins
    Yourong Zhou, Yashi Cao, Yiming Yin, Zhifei Xu, Xiaochun Yang, Bo Yang, Peihua Luo, Hao Yan, Qiao-Jun He · 2025 · Frontiers in Pharmacology
  98. Sex difference in liver-related mortality and transplantation associated with dietary cholesterol in chronic hepatitis C virus infection
    Lei Yu, Chihiro Morishima, George N. Ioannou · 2015 · British Journal Of Nutrition
  99. Effect of 14-Week Supplementation of Highly Purified Policosanol (Raydel®) and a Sugar Cane Extract Powder (SCEP) on Dyslipidemia and Oxidative Variables in Hyperlipidemic Zebrafish: Insight into Liver, Kidney, and Brain Health
    Kyung‐Hyun Cho, Ashutosh Bahuguna, Sang‐Hyuk Lee, Ji Eun Kim, Yunki Lee, Cheolmin Jeon · 2025 · Current Issues in Molecular Biology
  100. Loss of LCAT function aggravates metabolic-associated steatohepatitis (MASH) in golden Syrian hamster
    Yuqing Zhang, Huan Wang, Fuhua Wang, Xin Guo, Mingming Zhao, Zihao Zhou, Xiao Lin, Lemin Zheng, Yuhui Wang, Chaojie Liu et al. · 2025 · Clinical Science