Frequent Aneuploidy Among Normal Human Hepatocytes
Open accessAbstract
Murine hepatocytes become polyploid and then undergo ploidy reversal and become aneuploid in a dynamic process called the ploidy conveyor. Although polyploidization occurs in some types of human cells, the degree of aneuploidy in human hepatocytes is not known. We isolated hepatocytes derived from healthy human liver samples and determined chromosome number and identity using traditional karyotyping and fluorescence in situ hybridization. Similar to murine hepatocytes, human hepatocytes are highly aneuploid. Moreover, imaging studies revealed multipolar spindles and chromosome segregation defects in dividing human hepatocytes. Aneuploidy therefore does not necessarily predispose liver cells to transformation but might promote genetic diversity among hepatocytes.
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When polyploid hepatocytes divide they can give rise to aneuploid hepatocytes, causing genetic variation among hepatocytes in mice as well as humans.
“Additionally, when polyploid hepatocytes divide they can give rise to aneuploid hepatocytes, causing genetic variation among hepatocytes in mice as well as humans.32,36”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [36]
The paper states that dividing polyploid hepatocytes generate aneuploid cells in mice and reports division defects and aneuploidy in human hepatocytes (Abstract; page not provided). It says aneuploidy *might* promote genetic diversity among hepatocytes, whereas the citing sentence presents that consequence as established. (LLM, conf=0.84)
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References 16 · Cited by 197
Research works printed but not linked: 15
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- Authors
- Duncan, A. W., Hanlon Newell, A. E., Smith, L., Wilson, E. M., Olson, S. B., Thayer, M. J., Strom, S. C., & Grompe, M.
- Affiliations
- Oregon Health & Science University (US)
- University of Pittsburgh (US)
- Corresponding author
- Duncan, Andrew W.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 142
- Issue
- 1
- Pages
- 25-28
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC3244538
- OpenAlex
- W2161673895
- Cited by
- 197
- References
- 16
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 8 · 2023: 10 · 2022: 10 · 2021: 17 · 2020: 19 · 2019: 11 · 2018: 25 · 2017: 14 · 2016: 14 · 2015: 15 · 2014: 8 · 2013: 24 · 2012: 9
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (F32DK076232, R01DK051592)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- aneuploidy, human hepatocytes, polyploidy, polyploidization, chromosome segregation errors, multipolar spindles, karyology, fluorescence in situ hybridization, liver
- MeSH terms
- Adolescent, Adult, Aged, Aneuploidy, Animals, Child, Child, Preschool, Chromosomes, Human, Female, Humans, Hydrolases, Infant, Karyotyping, Male, Middle Aged, Genetic Variation, In Situ Hybridization, Fluorescence, Transplantation Chimera, Mice, Knockout, Hepatocytes, Mice, Young Adult
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