Cited by 396Epigenetics and DNA MethylationLiver Disease Diagnosis and TreatmentLiver physiology and pathology

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Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease

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Murphy, Susan K., Yang, Hyuna, Moylan, Cynthia A., Pang, Herbert, Dellinger, Andrew, Abdelmalek, Manal F., Garrett, Melanie E., Ashley–Koch, Allison, Suzuki, Ayako, Tillmann, Hans L., Hauser, Michael A., Diehl, Anna Mae·2013·Gastroenterology

DOI 10.1053/j.gastro.2013.07.047PMC PMC3805742

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Abstract

Background & aims Cirrhosis and liver cancer are potential outcomes of advanced nonalcoholic fatty liver disease (NAFLD). It is not clear what factors determine whether patients will develop advanced or mild NAFLD, limiting noninvasive diagnosis and treatment before clinical sequelae emerge. We investigated whether DNA methylation profiles can distinguish patients with mild disease from those with advanced NAFLD, and how these patterns are functionally related to hepatic gene expression.Methods We collected frozen liver biopsies and clinical data from patients with biopsy-proven NAFLD (56 in the discovery cohort and 34 in the replication cohort). Samples were divided into groups based on histologic severity of fibrosis: F0-1 (mild) and F3-4 (advanced). DNA methylation profiles were determined and coupled with gene expression data from the same biopsies; differential methylation was validated in subsets of the discovery and replication cohorts. We then analyzed interactions between the methylome and transcriptome.Results Clinical features did not differ between patients known to have mild or advanced fibrosis based on biopsy analysis. There were 69,247 differentially methylated CpG sites (76% hypomethylated, 24% hypermethylated) in patients with advanced vs mild NAFLD (P < .05). Methylation at fibroblast growth factor receptor 2, methionine adenosyl methyltransferase 1A, and caspase 1 was validated by bisulfite pyrosequencing and the findings were reproduced in the replication cohort. Methylation correlated with gene transcript levels for 7% of differentially methylated CpG sites, indicating that differential methylation contributes to differences in expression. In samples with advanced NAFLD, many tissue repair genes were hypomethylated and overexpressed, and genes in certain metabolic pathways, including 1-carbon metabolism, were hypermethylated and underexpressed.Conclusions Functionally relevant differences in methylation can distinguish patients with advanced vs mild NAFLD. Altered methylation of genes that regulate processes such as steatohepatitis, fibrosis, and carcinogenesis indicate the role of DNA methylation in progression of NAFLD.

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Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 12,082
The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
Chalasani, N., Younossi, Z. M., Lavine, J. E., Diehl, A. M., Brunt, E. M., Cusi, K. J., Charlton, M., & Sanyal, A. J. (2012) · Hepatology · doi:10.1002/hep.25762 · Cited by 3,854
Self-citation
DNA methylation and human disease
Robertson, K. D. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1655 · Cited by 2,864
The accessible chromatin landscape of the human genome
Thurman, R. E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M. T., Haugen, E., Sheffield, N. C., Stergachis, A. B., Wang, H., Vernot, B., et al. (2012) · Nature · doi:10.1038/nature11232 · Cited by 2,679
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
Irizarry, R. A., Ladd-Acosta, C., Wen, B., Wu, Z., Montano, C., Onyango, P., Cui, H., Gabo, K., Rongione, M., Webster, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.298 · Cited by 2,177
Transposable elements: targets for early nutritional effects on epigenetic gene regulation
Waterland, R. A., & Jirtle, R. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5293-5300.2003 · Cited by 2,019
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
Doi, A., Park, I., Wen, B., Murakami, P. N., Aryee, M. J., Irizarry, R. A., Herb, B. R., Ladd‐Acosta, C., Rho, J., Loewer, S., et al. (2009) · Nature Genetics · doi:10.1038/ng.471 · Cited by 1,201
The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease
McCullough, A. J. (2004) · Clinics in Liver Disease · doi:10.1016/j.cld.2004.04.004 · Cited by 580
Evaluation of the Infinium Methylation 450K technology
Dedeurwaerder, S., Defrance, M., Calonne, E., Denis, H., Sotiriou, C., & Fuks, F. (2011) · Epigenomics · doi:10.2217/epi.11.105 · Cited by 569
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation
Lu, S. C., Alvarez, L., Huang, Z.-Z., Chen, L., An, W., Corrales, F. J., Avila, M. A., Kanel, G., & Mato, J. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091016398 · Cited by 449

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Hagiwara, S., Nishida, N., Ueshima, K., Minami, Y., Komeda, Y., Aoki, T., Takita, M., Morita, M., Chishina, H., Yoshida, A., et al. (2021) · Cells · doi:10.3390/cells10113257 · Cited by 19
Advances in Noninvasive Biomarkers for Nonalcoholic Fatty Liver Disease
Gîlcă-Blanariu, G.-E., Budur, D. S., Mitrică, D., Gologan, E., Timofte, O., Bălan, G. G., OLTEANU, V.-A., & Ștefănescu, G. (2023) · Metabolites · doi:10.3390/metabo13111115 · Cited by 21
“Epigenetics refers to the diversity of gene expression not related to the DNA sequence itself and includes DNA methylation differences, which could be the reason for overexpression or underexpression of genes [185], histone modifications , and noncoding RNAs [17,186].”
Background
Identification of genes in hepatocellular carcinoma induced by non-alcoholic fatty liver disease
Cai, C., Song, X., & Yu, C. (2020) · Cancer Biomarkers · doi:10.3233/cbm-190169 · Cited by 19
Epigenome-wide DNA methylation profiling of portal vein tumor thrombosis (PVTT) tissues in hepatocellular carcinoma patients
Fan, X., Li, Y., Yi, X., Chen, G., Jin, S., Dai, Y., Cui, B., Dai, B., Lin, H. M., & Zhou, D. (2020) · Neoplasia · doi:10.1016/j.neo.2020.09.007 · Cited by 19
“nonalcoholic fatty liver disease) and liver cancer [28,29].”
Background
Role of cellular senescence in hepatic diseases (Review)
Xing, Y., & Zhu, J. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5623 · Cited by 19
“This signature is linked to the age‑associated progression of fibrosis, cirrhosis and even Hcc, as validated across diverse cohorts of liver disease patients (101).”
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Fernández‐Ramos, D., Lopitz‐Otsoa, F., Millet, Ó., Alonso, C., Lu, S. C.-L., & Mato, J. M. (2022) · Livers · doi:10.3390/livers2040020 · Cited by 18
“Of the eleven genes most important for their quantitative contribution to maintain the flow of carbon units through 1CM in the liver (MAT1A, AMD1, GNMT, PEMT, GAMT, AHCY, CBS, BHMT, MTR, MTHFR, and SHMT1/2), the mRNA content of six of them— catalyzing SAMe synthesis (MAT1A) and catabolism (GNMT), homocysteine synthesi…”
Background
Thrombospondin 2 is a key determinant of fibrogenesis in non‐alcoholic fatty liver disease
Kimura, T., Iwadare, T., Wakabayashi, S., Kuldeep, S., Nakajima, T., Yamazaki, T., Aomura, D., Zafar, H., Iwaya, M., Joshita, S., et al. (2023) · Liver International · doi:10.1111/liv.15792 · Cited by 19
Impact of Transgenerational Nutrition on Nonalcoholic Fatty Liver Disease Development: Interplay between Gut Microbiota, Epigenetics and Immunity
Tzeng, H., & Lee, W.-C. (2024) · Nutrients · doi:10.3390/nu16091388 · Cited by 18
“Another study demonstrated that differentially expressed hepatic DNA methylation patterns can distinguish patients with advanced or mild NAFLD [87].”
Background
Drug metabolism and liver disease: a drug–gene–environment interaction
Zgheib, N., & Branch, R. (2017) · Drug metabolism reviews (Softcover ed.) · doi:10.1080/03602532.2016.1271807 · Cited by 17
“For example, it is now established that CYP2E1 is increased in patients with NAFLD and NASH (Chalasani et al., 2003; Merrell & Cherrington, 2011; Orellana et al., 2006; Weltman et al., 1998).”
BackgroundInfluential
Non-alcoholic fatty liver disease: molecular and cellular interplays of the lipid metabolism in a steatotic liver
Ramos, L. F., da Silva, C. M., Pansa, C. C., & Moraes, K. C. M. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1820321 · Cited by 18
Signal Transduction and Molecular Regulation in Fatty Liver Disease
Dong, X. C., Chowdhury, K., Huang, M., & Kim, H.-G. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0076 · Cited by 18
“Hypomethylation of the genes of caspase-1 ( CASP1 ) and ﬁbroblast growth factor receptor 2 ( FGFR2 ) has been associated with hepatic ﬁbrosis (137).”
Gene Signatures Detect Damaged Liver Sinusoidal Endothelial Cells in Chronic Liver Diseases
Verhulst, S., van Os, E. A., Smet, V. D., Eysackers, N., Mannaerts, I., & van Grunsven, L. A. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.750044 · Cited by 17
“F0–F1 (GSE49541) (43), alcoholic steatohepatitis (ASH) vs.”
Decoding liver injury: A regulatory role for histone modifications
Tian, W., & Xu, Y. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.03.009 · Cited by 18
“For example, Murphy et al have provided one of first snapshots for a role of DNA methylation and liver transcriptome in patients with non-alcoholic fatty liver disease (NAFLD) (Murphy et al. , 2013).”
Epigenetics and mitochondrial dysfunction insights into the impact of the progression of non‐alcoholic fatty liver disease
Guha, S., Sesili, S., Mir, I. H., & Thirunavukkarasu, C. (2022) · Cell Biochemistry and Function · doi:10.1002/cbf.3763 · Cited by 18
“, gene silencing.(18) Apart from nuclear DNA, mitochondrial DNA is subjected to distinct methylation patterns during varying phases of NAFLD.”
BackgroundInfluential
Integrated multiple-microarray analysis and mendelian randomization to identify novel targets involved in diabetic nephropathy
Fan, C., Gao, Y., & Sun, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1191768 · Cited by 17
“Gene-specific expression profiling has recently been extensively adopted to analyze microarray data using bioinformatics methods (5, 6).”
Method
DNA methylome analysis reveals epigenetic alteration of complement genes in advanced metabolic dysfunction-associated steatotic liver disease
Magdy, A., Kim, H., Go, H., Lee, J. M., Sohn, H. A., Haam, K., Jung, H.-J., Park, J., Yoo, T., Kwon, E., et al. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0229 · Cited by 18
A genome‐scale DNA methylation study in women with interstitial cystitis/bladder pain syndrome
Bradley, M. S., Burke, E. E., Grenier, C., Amundsen, C. L., Murphy, S. K., & Siddiqui, N. Y. (2018) · Neurourology and Urodynamics · doi:10.1002/nau.23489 · Cited by 17
“In addition to finding specific pathways significantly enriched for of our “top hit”CpGs, having more than one significant CpG site in the same gene also decreases the likelihood of false discovery.(21) In this regard there were 28 genes with two or more significant differentiallymethylatedCpGsites.”
BackgroundSelf-citation
Epigenetic Aspects and Prospects in Autoimmune Hepatitis
Czaja, A. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.921765 · Cited by 17
DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis
Iguchi, E., Takai, A., Takeda, H., Kumagai, K., Arasawa, S., Eso, Y., Shimizu, T., Ueda, Y., Marusawa, H., & Seno, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-78151-2 · Cited by 16
A set of common buccal CpGs that predict epigenetic age and associate with lifespan-regulating genes
Johnson, A. A., Torosin, N. S., Shokhirev, M. N., & Cuellar, T. L. (2022) · iScience · doi:10.1016/j.isci.2022.105304 · Cited by 16
A crosstalk between epigenetic modulations and non-alcoholic fatty liver disease progression
Ramezani, M., Zobeiry, M., Abdolahi, S., Hatami, B., Zali, M. R., & Baghaei, K. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154809 · Cited by 16
Dysregulated Epigenetic Modifications in the Pathogenesis of NAFLD-HCC
Zhao, F. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-8684-7_7 · Cited by 17
Potential Blood DNA Methylation Biomarker Genes for Diagnosis of Liver Fibrosis in Patients With Biopsy-Proven Non-alcoholic Fatty Liver Disease
Sun, Q., Tang, L., Wang, M., Zhu, P., Li, Y., Ma, H., Huang, O., Hong, L. L., Li, G., Byrne, C. D., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.864570 · Cited by 17
“human genes in the livers with advanced fibrosis were generally hypomethylated relative to those in the livers with mild fibrosis (45).”
Background
Ptpn1 deletion protects oval cells against lipoapoptosis by favoring lipid droplet formation and dynamics
Barahona, I., Rada, P., Calero‐Pérez, S., Grillo-Risco, R., Pereira, L., Soler‐Vázquez, M. C., Laiglesia, L. M., Moreno-Aliaga, M. J., Herrero, L., Serra, D., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01023-x · Cited by 16
ER Disposal Pathways in Chronic Liver Disease: Protective, Pathogenic, and Potential Therapeutic Targets
Duwaerts, C. C., & Maiers, J. L. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.804097 · Cited by 17
Biological Effects of Korean Red Ginseng Polysaccharides in Aged Rat Using Global Proteomic Approach
Lee, Y. Y., Kim, S., Youn, S.-H., Hyun, S. H., Kyung, J.-S., In, G., Park, C.-K., Jung, H. R., Moon, S. J., Kang, M. J., et al. (2020) · Molecules · doi:10.3390/molecules25133019 · Cited by 15
“There are also reports linking Mat and liver dysfunction, which detailed that patients with advanced NAFLD exhibit Mat1a hypermethylation and lower Mat1a mRNA levels, compared to patients with mild NAFLD and normal subjects [45].”
Background
DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease
Tommasi, S., & Besaratinia, A. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16152791 · Cited by 15
Cell-free DNA methylation as liquid biopsy for the assessment of fibrosis in patients with nonalcoholic steatohepatitis: a gap between innovation and implementation.
Sookoian, S., & Pirola, C. (2017) · Hepatobiliary surgery and nutrition · doi:10.21037/hbsn.2017.01.07 · Cited by 16
“Robust evidence yielded by human studies has demonstrated that NAFLD severity is associated with a consistent pattern in the methylome and transcriptome of the liver tissue characterized by hypermethylation and down-regulation of genes involved in metabolic function (3,5,15) versus hypomethylation and up-regulation of…”
Background
Profiling the genome and proteome of metabolic dysfunction-associated steatotic liver disease identifies potential therapeutic targetsPreprint
Liu, J., Hu, S., Chen, L., Daly, C., Prada‐Medina, C. A., Richardson, T. G., Traylor, M., Dempster, N. J., Mbasu, R. J., Monfeuga, T., et al. (2023) · medRxiv · doi:10.1101/2023.11.30.23299247 · Cited by 22
Metabolic dysfunction-associated fatty liver disease: advances in genetic and epigenetic implications
Pirola, C. J., & Sookoian, S. (2021) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000814 · Cited by 14
Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children
Moylan, C. A., Mavis, A., Jima, D. D., Maguire, R. L., Bashir, M. R., Hyun, J., Cabezas, M., Parish, A., Niedzwiecki, D., Diehl, A. M., et al. (2022) · Epigenetics · doi:10.1080/15592294.2022.2039850 · Cited by 14
Self-citation
Role of genetic variants and DNA methylation of lipid metabolism-related genes in metabolic dysfunction-associated steatotic liver disease
Wang, J., Chen, X.-Y., Zhang, Y., Shen, Y., Zhu, M.-L., Zhang, J., & Zhang, J. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1562848 · Cited by 15
Under-Evaluated or Unassessed Pathogenic Pathways in Autoimmune Hepatitis and Implications for Future Management
Czaja, A. J. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5072-x · Cited by 14
Relationship between changes in the exon-recognition machinery and SLC22A1 alternative splicing in hepatocellular carcinoma
Soto, M., Reviejo, M., Al‐Abdulla, R., Romero, M. R., Macı́as, R. I. R., Boix, L., Bruix, J., Serrano, M. A., & Marı́n, J. J. G. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165687 · Cited by 14
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Gallon, J., Coto‐Llerena, M., Ercan, C., Bianco, G., Paradiso, V., Nuciforo, S., Taha‐Mehlitz, S., Meier, M., Boldanova, T., Pérez‐del‐Pulgar, S., et al. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13154 · Cited by 14
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Yang, M., Li, W.-Y., Wu, C., Lee, Y., Chen, A. Y.-N., Tyan, Y., & Chen, Y. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710072 · Cited by 14
“In addition, downregulation of GNMT has been demonstrated in the liver tissue of NAFLD patients, occurring even during early stages of chronic liver disease [13,14].”
Background
Epigenetic regulation of liver fibrosis
Page, A., & Mann, D. A. (2015) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2015.05.013 · Cited by 14
Analysis of diet-induced differential methylation, expression, and interactions of lncRNA and protein-coding genes in mouse liver
Silva, J., & Booven, D. V. (2018) · Scientific Reports · doi:10.1038/s41598-018-29993-4 · Cited by 14
Association Between Active DNA Demethylation and Liver Fibrosis in Individuals with Metabolic-Associated Steatotic Liver Disease (MASLD)
Barchetta, I., Zampieri, M., Cimini, F. A., Dule, S., Sentinelli, F., Passarella, G., Oldani, A., Karpach, K., Bacalini, M. G., Baroni, M. G., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031271 · Cited by 14
“Hypomethylation, however, appears to be the predominant alteration in MASLD [24–27], affecting specific genes and repetitive sequences with implications for tissue repair, energy metabolism, and carcinogenesis in the liver.”
Association between advanced fibrosis and epigenetic age acceleration among individuals with MASLD
Wang, H., Liu, Z., Fan, H. X., Guo, C., Zhang, X., Li, Y., Zhao, S., Dai, L., Zhao, M., & Zhang, T. (2024) · Journal of Gastroenterology · doi:10.1007/s00535-024-02181-0 · Cited by 16
The Proteomics of MASLD Progression: Insights From Functional Analysis to Drive the Development of New Therapeutic Solutions
Pirola, C. J., Gianotti, T. F., & Sookoian, S. C. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.18468 · Cited by 13
Integrated Analysis of Key Genes and Pathways Involved in Nonalcoholic Steatohepatitis Improvement After Roux-en-Y Gastric Bypass Surgery
Fu, C., Zhou, Y. J., Wu, Z., Li, Y., Zhou, W., & Wang, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.611213 · Cited by 13
“Microarray technology has also been used in the liver of NASH patients and animal models to detect differentially expressed genes (DEGs), screen disease biomarkers, or find new therapeutic targets (11, 12).”
Background
The progress of epigenetics in the development and progression of non-alcoholic fatty liver disease
Xu, F. L., & Guo, W. (2020) · Liver Research · doi:10.1016/j.livres.2020.08.003 · Cited by 13
Maternal Diet Alters Trained Immunity in the Pathogenesis of Pediatric NAFLD
Jonscher, K. R., Abrams, J., & Friedman, J. E. (2020) · Journal of Cellular Immunology · doi:10.33696/immunology.2.061 · Cited by 12
“DNA methylation, covalent modification of histones, and the expression of non-coding RNA are epigenetic phenomena found in livers from children [22-25], adults [26-33], and rodents [34-39] with NAFLD (reviewed recently by Campisano, et al.”
Background
Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters
Pan, X., Wu, Y., Peng, H., Cai, X., Hu, Z., Xu, L., & Peng, X. (2021) · Digestive and Liver Disease · doi:10.1016/j.dld.2021.05.013 · Cited by 13
Systems biology for hepatologists
Mato, J. M., Martínez‐Chantar, M. L., & Lu, S. C.-L. (2014) · Hepatology · doi:10.1002/hep.27023 · Cited by 13
Combined Methylation and Transcriptome Analysis of Liver Injury of Nonalcoholic Fatty Liver Disease Induced by High Alcohol-Producing Klebsiella pneumoniae
Zhang, R., Xu, Z., Xue, G., Feng, J., Du, B., Gan, L., Fan, Z., Fu, T., Feng, Y., Zhao, H., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.05323-22 · Cited by 12
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Background
Aldehyde dehydrogenase 1 family: A potential molecule target for diseases
Duan, X., Hu, H., Wang, L., & Chen, L. (2024) · Cell Biology International · doi:10.1002/cbin.12188 · Cited by 11
DNA methylation controls liver fibrogenesis
Liu, X., & Brenner, D. A. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.16 · Cited by 12
Promotor methylation: Does it affect response to therapy in chronic hepatitis C (G4) or fibrosis?
Zekri, A. N., Raafat, A. M., elmasry, S., Bahnassy, A. A., Saad, Y., Dabaon, H. A., El‐Kassas, M., Shousha, H. I., Nassar, A. A.-M., EL-Dosouky, M. A., et al. (2014) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31251-7 · Cited by 12
Epigenetic Changes Associated With Obesity-related Metabolic Comorbidities
Sandovici, I., Morais, T., Constância, M., & Monteiro, M. P. (2025) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaf129 · Cited by 16
“These genes were highlighted within pathway-level analyses, reflecting coordinated epigenetic remodeling rather than isolated gene-specific effects [ 148].”
Sensing of Liver‐Derived Nicotinamide by Intestinal Group 2 Innate Lymphoid Cells Links Liver Cirrhosis and Ulcerative Colitis Susceptibility
Shen, J., Zhen, L. I., Liu, X., Zheng, M., Zhang, P., Chen, Y., Tian, Q., Tian, W., Kou, G., Cui, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202404274 · Cited by 10
Significance of Circulating Cell-Free DNA Species in Non-Alcoholic Fatty Liver Disease
Chrysavgis, L., Papatheodoridi, A. M., Cholongitas, Ε., Koutsilieris, M., Papatheodoridis, G., & Chatzigeorgiou, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168849 · Cited by 12
“Moreover, it has been previously shown that NAFLD progression is associated with hypermethylation and subsequent downregulation of the expression of genes involved in metabolic processes accompanied with hypomethylation and upregulation of genes implicated in liver regeneration and tissue repair [27].”
Background
Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets
Aissa, A. F., Tryndyak, V., de Conti, A., Machado, A. R. T., Tuttis, K., Machado, C. D. S., Hernandes, L. C., dos Santos, P. W. D. S., Serpeloni, J. M., Pogribny, I. P., et al. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.112938 · Cited by 11
Using epigenomics to understand cellular responses to environmental influences in diseases
Wattacheril, J. J., Raj, S. M., Knowles, D. A., & Greally, J. M. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010567 · Cited by 12
“The Ahrens study in Table 2 accomplished this in a clever manner, sampling liver before and after bariatric surgery [53].”
Background
Role of sterile inflammation in fatty liver diseases
Chen, Y., Yousaf, M. N., & Mehal, W. Z. (2018) · Liver Research · doi:10.1016/j.livres.2018.02.003 · Cited by 11
Newborn and childhood differential DNA methylation and liver fat in school-age children
Geurtsen, M. L., Jaddoe, V. W. V., Salas, L. A., Santos, S., & Felix, J. F. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0799-6 · Cited by 10
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Tryndyak, V., Willett, R. A., Avigan, M., Sanyal, A. J., Beland, F. A., Rusyn, I., & Pogribny, I. P. (2022) · Epigenetics · doi:10.1080/15592294.2022.2043590 · Cited by 11
Sugar sweetened beverages and fatty liver disease: Rising concern and call to action
Abdelmalek, M. F., & Day, C. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.05.021 · Cited by 11
“Journal of Hepatology 201 or epigenetic risk factors [18,19] are associated with fructoserelated liver injury remains unknown.”
BackgroundSelf-citation
Breakthroughs in Epigenetics
Anand, S., Navgeet, & Gill, B. S. (2015) · Pharmatutor · Cited by 10
Metabolic liver cancer: associations of rare and common germline variants in one-carbon metabolism and DNA methylation genes
Antwi, S. O., Heckman, M. G., White, L. J., Yan, I. K., Sarangi, V., Lauer, K. P., Reddy, J. S., Ahmed, F. Y., Veliginti, S., Febres, E. D. M., et al. (2023) · Human Molecular Genetics · doi:10.1093/hmg/ddad099 · Cited by 11
Whole-genome DNA methylation and gene expression profiling in the livers of mice with nonalcoholic steatohepatitis
Bi, H., Zhou, B., Yang, J., Lü, Y., Mao, F., & Song, Y. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121951 · Cited by 10
Practical Aspects of Clinical Manifestations, Pathogenesis and Therapy of Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease: Expert Opinion
Tsukanov, V. V., Осипенко, М. Ф., Beloborodova, E. V., Livzan, M. A., Борисович, Х. И., Alekseenko, S. A., Sivolap, Y. P., Tonkikh, Y. L., & Vasyutin, A. V. (2023) · Russian Journal of Gastroenterology Hepatology Coloproctology · doi:10.22416/1382-4376-2023-33-4-7-13 · Cited by 10
Glycoprotein nonmetastatic melanoma protein B is regulated by hepatic peroxisome proliferator-activated receptor γ in liver steatosis
Aibara, D., & Matsusue, K. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111678 · Cited by 10
S-adenosylmethionine deficit disrupts very low-density lipoprotein metabolism promoting liver lipid accumulation in mice
Luque-Urbano, M. R., Fernández‐Ramos, D., Lopitz‐Otsoa, F., de Juan, V. G., Bizkarguenaga, M., Castro-Espadas, L., Hermoso-Martínez, U., Barbier‐Torres, L., Lu, S. C.-L., Millet, Ó., et al. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100794 · Cited by 11
Epigenetic memory of environmental exposures as a mediator of liver disease
Hlady, R. A., & Robertson, K. D. (2023) · Hepatology · doi:10.1097/hep.0000000000000414 · Cited by 10
Role of vascular endothelial growth factor B in nonalcoholic fatty liver disease and its potential value
Li, Y.-Q., Xin, L., Zhao, Y., Li, S.-Q., & Li, Y.-N. (2023) · World Journal of Hepatology · doi:10.4254/wjh.v15.i6.786 · Cited by 10
Hepatic DNA Methylation Is Affected by Hepatocellular Carcinoma Risk in Patients with and without Hepatitis Virus
Nishida, N., Iwanishi, M., Minami, T., Chishina, H., Arizumi, T., Takita, M., Kitai, S., Yada, N., Ida, H., Hagiwara, S., et al. (2015) · Digestive Diseases · doi:10.1159/000439098 · Cited by 10
Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and HCV co-infection
Whitmill, A., Kim, S., Rojas, V. K., Gulraiz, F., Afreen, K. S., Jain, M. K., Singh, M., & Park, I.-W. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202524 · Cited by 10
Identification of common signature genes and pathways underlying the pathogenesis association between nonalcoholic fatty liver disease and atherosclerosis
Mo, S., Wang, Y., Yuan, X., Wu, W.-H., Zhao, H., Wei, H., Qin, H., Jiang, H., & Qin, S. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1142296 · Cited by 9
“In the dataset of GSE49541, a total of 72 NAFLD samples were divided into two groups based on the histologic severity of fibrosis: F0–1 (mild) and F3–4 (advanced) (14).”
BackgroundMethod
Salusin‑α alleviates lipid metabolism disorders via regulation of the downstream lipogenesis genes through the LKB1/AMPK pathway
Pan, J., Yang, C., Xu, A., Zhang, H., Fan, Y., Zeng, R., Chen, L., Liu, X., & Wang, Y. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5397 · Cited by 9
Metabolic Dysfunction-Associated Steatotic Liver Disease and Alcohol-Associated Liver Disease: Liver DNA Methylation Analysis—A Systematic Review
Stols‐Gonçalves, D., Meijnikman, A. S., Tristão, L. S., dos Santos, C. L., Denswil, N. P., Verheij, J., Bernardo, W. M., & Nieuwdorp, M. (2024) · Cells · doi:10.3390/cells13221893 · Cited by 11
Two differentially methylated region networks in nonalcoholic fatty liver disease, viral hepatitis, and hepatocellular carcinoma
Kurokawa, S., Yoneda, M., Ogawa, Y., Honda, Y., Kessoku, T., Imajo, K., Saito, S., Nakajima, A., & Hotta, K. (2022) · BMC Gastroenterology · doi:10.1186/s12876-022-02360-4 · Cited by 9
“For DNA methylation analysis, we used the following datasets: our recently published Japanese hepatic DNA methylation data of NAFLD (JGAS000059, http:// trace. ddbj. nig. ac. jp/ jga/ index. html) [13], American hepatic DNA methylation data of NAFLD (NCBI Gene Expression Omnibus accession number GSE31803) [15], Japane…”
BackgroundInfluential
The Roles of Natural Compounds in Epigenetics
Yang, Y., Chi, Z.-H., Gao, R., & Lei, Z. (2018) · Natural Product Communications · doi:10.1177/1934578x1801300835 · Cited by 9
A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies
Lefever, D. E., Miedel, M. T., Pei, F., DiStefano, J. K., DeBiasio, R., Shun, T. Y., Saydmohammed, M., Chikina, M. D., Vernetti, L. A., Soto–Gutiérrez, A., et al. (2022) · Metabolites · doi:10.3390/metabo12060528 · Cited by 12
“mild fibrosis) [79] (Figure S3; for details see https://github.”
Background
Nutrients as epigenetic modulators in metabolic dysfunction-associated steatotic liver disease
Rodríguez, S., Dahlem, M. L. F., Rossoni, C., Marroni, N. P., Marroni, C. A., & Fernandes, S. A. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i8.108182 · Cited by 8
A liver secretome gene signature-based approach for determining circulating biomarkers of NAFLD severity
Hagemann, C. A., Legart, C., Møllerhøj, M. B., Madsen, M. R., Hansen, H. H., Kønig, M. J., Helgstrand, F., Hjørne, F., Toxværd, A., Langhoff, J. L., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0275901 · Cited by 10
“…of α 2AP have been associated with advanced liver fibrosis in two studies characterizing the plasma proteome in NAFLD patients and controls [9, 43], and decreased plasma concentrations of SAM and hepatic expression levels of MAT1A have been associated with NAFLD and/ or liver fibrosis [12, 44, 45].”
EMP1 as a Potential Biomarker in Liver Fibrosis: A Bioinformatics Analysis
Chen, X., Lv, X., Han, M., Hu, Y., Zheng, W., Xue, H., Li, Z., Li, K., & Tan, W. (2023) · Gastroenterology Research and Practice · doi:10.1155/2023/2479192 · Cited by 10
“Moreover, EMP1 is greater higher expressed in samples of NAFLD liver biopsy tissues recovered from advanced (fibrotic stage 3–4) compared to moder- ate samples (fibrotic stage 0–1) in GSE49541 (log2FC=1.152, P = 3:26 × 10−4; Figure 3(h)).”
MethodInfluential
Dietary Pattern’s Role in Hepatic Epigenetic and Dietary Recommendations for the Prevention of NAFLD
Martin, J., & Bars‐Cortina, D. (2024) · Nutrients · doi:10.3390/nu16172956 · Cited by 8
Prognostication in NAFLD: physiological bases, clinical indicators, and newer biomarkers
Terracciani, F., Falcomatà, A., Gallo, P., Picardi, A., & Gentilucci, U. V. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-022-00934-0 · Cited by 9
“Furthermore, genetic predisposition and epigenetic modifications determine hepatic transcriptome dynamics [130] [131].”
Background
Epigenetic Network in Immunometabolic Disease
Geiger, M. A., Gorica, E., Mohammed, S. A., Mongelli, A., Mengozzi, A., Delfine, V., Ruschitzka, F. T., Costantino, S., & Paneni, F. (2023) · Advanced Biology · doi:10.1002/adbi.202300211 · Cited by 8
Characterizing disease progression of nonalcoholic steatohepatitis in Leptin -deficient rats by integrated transcriptome analysis
Lü, P., Yang, G., Jiang, L., He, W., Wu, W., Qi, L., Shen, S., Rao, J., Zhang, P., Xue, Z., et al. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220976530 · Cited by 8
“To understand the mechanism of disease progression, previous studies have investigated the transcriptome of liver biopsies from NAFLD patients at mild, medium, and severe stages.(17,18) However, the heterogeneities in different patients cannot reflect the temporal progression of the disease in a particular person.”
Background
α‐Lipoic Acid Increases Collagen Synthesis and Deposition in Nondiabetic and Diabetic Rat Kidneys
Grdović, N., Rajić, J., Јovanović, J. A., Dinić, S., Tolić, A., Đorđević, M., Đorđević, M., Trifunović, S. L., Vidaković, M., Uskoković, A. S., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6669352 · Cited by 8
“Human methylome and transcriptome studies revealed correlation of Col4a1 promoter methylation with its expression in healthy and liver cells activated to produce ECM proteins [20, 48].”
Background
Longitudinal association of peripheral blood DNA methylation with liver fat content: distinguishing between predictors and biomarkers
Zeng, H.-L., Li, W., Xia, M.-F., Ge, J., Ma, H., Chen, L.-Y., Pan, B.-S., Lin, H., Wang, S., & Gao, X. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02304-9 · Cited by 9
Identification of disease-related genes and construction of a gene co-expression database in non-alcoholic fatty liver disease
Ye, H., Sun, M., Su, M., Chen, D., Liu, H., Ma, Y., Luo, W., Li, H., & Xu, F. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1070605 · Cited by 9
“The transcriptome of NAFLD patients has been profiled in several studies (Ahrens et al., 2013; Murphy et al., 2013; Arendt et al., 2015; Hoang et al., 2019; Azzu et al., 2021; Pantano et al., 2021).”
Background
Histone Demethylation Profiles in Nonalcoholic Fatty Liver Disease and Prognostic Values in Hepatocellular Carcinoma: A Bioinformatic Analysis
Liu, Y., & Chen, M. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45040237 · Cited by 7
Identification of differentially methylated regions associated with both liver fibrosis and hepatocellular carcinoma
Kurokawa, S., Kobori, T., Yoneda, M., Ogawa, Y., Honda, Y., Kessoku, T., Imajo, K., Saito, S., Nakajima, A., & Hotta, K. (2024) · BMC Gastroenterology · doi:10.1186/s12876-024-03149-3 · Cited by 7
Genome-wide analysis of DNA methylation identifies novel differentially methylated regions associated with lipid accumulation improved by ethanol extracts of Allium tubersosum and Capsella bursa-pastoris in a cell model
Hong, M., Hwang, J., Shin, E. J., Hur, H. J., Kang, K., Choi, H., Chung, M., Chung, S., Sung, M. J., & Park, J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217877 · Cited by 7
Rewriting the MASLD ‐associated hepatocellular carcinoma script: Targeting epigenetics and metabolism
Aiello, C., Felli, É., Musarra, T., Nevi, L., Altomare, A., Gracia‐Sancho, J., Baiocchini, A., & Carotti, S. (2025) · International Journal of Cancer · doi:10.1002/ijc.70047 · Cited by 6
Emerging Perspectives in the Diagnosis and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Narrative Review
Djeagou, A., Gunukula, K., Sermani, A., & Vaspari, S. K. (2025) · Cureus · doi:10.7759/cureus.95288 · Cited by 8
“Studies indicate that unique methylation patterns distinguish moderate from advanced MASLD [5,17].”
Alterations in the hepatocyte epigenetic landscape in steatosis
Maji, R. K., Czepukojc, B., Scherer, M., Tierling, S., Cadenas, C., Gianmoena, K., Gasparoni, N., Nordström, K. J. V., Gasparoni, G., Laggai, S., et al. (2023) · Epigenetics & Chromatin · doi:10.1186/s13072-023-00504-8 · Cited by 7
“Gianmoena K, et al. Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria.”
BackgroundInfluential
Unveiling the mitophagy puzzle in non-alcoholic fatty liver disease (NAFLD): Six hub genes for early diagnosis and immune modulatory roles
Luo, Z., Yan, S., Chao, Y., & Shen, M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28935 · Cited by 6
“A total of 3 NAFLD-related datasets GSE49541[15], GSE89632[16] and GSE63067[17] were retrieved from the Gene Expression Omnibus (GEO) database [18] using the R package GEOquery [19].”
Method
Epigenetics in metabolic dysfunction-associated steatohepatitis
Zhang, Y., Ding, R., Hu, L., Liu, E., & Qu, P. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111684 · Cited by 6
Drug-Induced Liver Injury
Urban, T. J., & Tillmann, H. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386882-4.00022-0 · Cited by 6
Self-citation
Regulation of P300 and HDAC1 on endoplasmic reticulum stress in isoniazid‐induced HL‐7702 hepatocyte injury
Li, J., Li, Y., Zhang, Y., Sun, S., Han, T., Li, Y., & Feng, F. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28175 · Cited by 6
“P300 and HDAC1 have been shown to be related to various liver diseases, such as nonalcoholic fatty liver disease (Murphy et al., 2013) and primary biliary cholangitis (X. Zhang et al., 2014).”
Background
Liver gene regulatory networks: Contributing factors to nonalcoholic fatty liver disease
Cebola, I. (2020) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1480 · Cited by 5
“Global changes in DNA methylation and hydroxymethylation have also been implicated in NAFLD (Ahrens et al., 2013; Lyall et al., 2019; Murphy et al., 2013; Zeybel et al., 2015), and stronger DNA methyltransferase expression has been associated with NAFLD severity (Pirola et al., 2013).”
Background
The Co-occurrence of Chronic Hepatitis B and Fibrosis Is Associated With a Decrease in Hepatic Global DNA Methylation Levels in Patients With Non-alcoholic Fatty Liver Disease
Li, F., Ou, Q., Lai, Z., Pu, L., Chen, X., Wang, L., Sun, L., Liang, X., Wang, Y., Xu, H., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.671552 · Cited by 6
Crosstalk between Epigenetics and Autophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease
Zahoor, I., Mir, G. J., Lone, N. A., & Ashraf, N. U. (2025) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes24041 · Cited by 5
“115 This suggests that epigenetic alterations may mediate pathways that suppress autophagy in MASLD.”
The relationship between folic acid and nonalcoholic fatty liver disease
Xu, B., Yang, X., Zhu, X., Liu, Q., Zhang, Y., Zhang, M., Fan, C., Ban, X., Aikebaier, G., & Bian, H. (2024) · Clinical and Translational Discovery · doi:10.1002/ctd2.274 · Cited by 5
Accelerators of chronic hepatitis B fibrosis cirrhosis CCND1 gene expression and promoter hypomethylation
Chen, N., Luo, P., Tang, Y., Liu, P., Wang, J., Fan, Y., Han, L., & Wang, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-93778-9 · Cited by 5
“Moreover, the dynamic characteristics of methylation make it a viable target for therapeutic intervention 17,33–35 .”

Authors: Murphy, S. K., Yang, H., Moylan, C. A., Pang, H., Dellinger, A., Abdelmalek, M. F., Garrett, M. E., Ashley–Koch, A., Suzuki, A., Tillmann, H. L., Hauser, M. A., & Diehl, A. M.
Affiliations: Duke University (US)
Corresponding author: Diehl, Anna Mae
ORCID: Murphy, Susan K.
Yang, Hyuna
Moylan, Cynthia A.
Pang, Herbert
Dellinger, Andrew
Abdelmalek, Manal F.
Suzuki, Ayako
Tillmann, Hans L.
Hauser, Michael A.
Diehl, Anna Mae
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2013-11
Volume: 145
Issue: 5
Pages: 1076-1087
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2013.07.047
PMC: PMC3805742
OpenAlex: W2150020322
Cited by: 391
References: 48
Citations by year: 2026: 14 · 2025: 23 · 2024: 36 · 2023: 37 · 2022: 31 · 2021: 35 · 2020: 31 · 2019: 38 · 2018: 40 · 2017: 32 · 2016: 26 · 2015: 28 · 2014: 17 · 2013: 2
FWCI: 10.89
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders: National Institutes of Health (5rc2aa019399-02)
National Institute on Alcohol Abuse and Alcoholism (5RC2-AA019399, RC2-AA019399)
National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007568)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: non-alcoholic fatty liver disease, DNA methylation, transcriptome, liver fibrosis, disease severity, differentially methylated CpG sites, gene expression, FGF2, MAT1A, caspase-1, one-carbon metabolism, NAFLD progression, non-invasive diagnosis
MeSH terms: Adult, Biopsy, Diagnosis, Differential, Fatty Liver, Female, Gene Expression Regulation, Humans, Liver, Male, Methionine Adenosyltransferase, Middle Aged, Severity of Illness Index, Cohort Studies, Disease Progression, CpG Islands, DNA Methylation, Caspase 1, Receptor, Fibroblast Growth Factor, Type 2, Transcriptome, Non-alcoholic Fatty Liver Disease

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Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease

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