Proton Pump Inhibitors Decrease Phlebotomy Need in HFE Hemochromatosis: Double-Blind Randomized Placebo-Controlled Trial
Open accessAbstract
Phlebotomy constitutes the established treatment for HFE-related hemochromatosis. Retrospective studies have suggested proton pump inhibitors (PPIs) reduce the need for phlebotomy in this population. We conducted a randomized controlled trial to prove this. Thirty p.C282Y homozygous patients were randomly allocated to PPI (pantoprazole 40 mg/day) or placebo for 12 months. Phlebotomies were performed when serum ferritin was > 100 μg/L. Phlebotomy need turned out to be significantly lower in patients taking PPI (P = .0052). PPI treatment significantly reduces the need for phlebotomies in p.C282Y homozygous patients. In view of the known long-term safety profile of PPI, they can be a valuable addition to standard therapy. Clinicaltrials.gov: NCT01524757.
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The use of proton pump inhibitors reduced the need for phlebotomy in patients with hemochromatosis.
“The use of proton pump inhibitors reduced the need for phlebotomy in patients with hemochromatosis.132”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [132]
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References 11 · Cited by 68
- Authors
- Vanclooster, A., van Deursen, C., Jaspers, R., Cassiman, D., & Koek, G.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- Laurentius Ziekenhuis (NL)
- Maastricht University Medical Centre (NL)
- Corresponding author
- Koek, Ger
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 153
- Issue
- 3
- Pages
- 678-680.e2
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2624862391
- Cited by
- 68
- References
- 11
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 3 · 2023: 4 · 2022: 30 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 1
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Lirias (submittedVersion, other-oa)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- proton pump inhibitors, pantoprazole, HFE hemochromatosis, phlebotomy, serum ferritin, iron overload, HFE gene mutations
- MeSH terms
- Hemochromatosis Protein, Pantoprazole, Adult, Double-Blind Method, Female, Ferritins, Hemochromatosis, Homozygote, Humans, Male, Middle Aged, Phlebotomy, 2-Pyridinylmethylsulfinylbenzimidazoles, Proton Pump Inhibitors
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