The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer
Open accessAbstract
Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. We review recently developed approaches for reshaping the pancreatic tumor stroma and discuss how these might improve patient outcomes. We also describe relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and discuss the implications for the development of stromal compartment-specific therapies.
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Cites
Tumour exosome integrins determine organotropic metastasis
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Self-citationModeling Development and Disease with Organoids
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Organogenesis in a dish: Modeling development and disease using organoid technologies
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Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
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Whole genomes redefine the mutational landscape of pancreatic cancer
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Self-citationDistinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
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Distant metastasis occurs late during the genetic evolution of pancreatic cancer
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Cited by
Van Cutsem, E., Tempero, M. A., Sigal, D., Oh, D.-Y., Fazio, N., Macarulla, T., Hitre, E., Hammel, P., Hendifar, A. E., Bates, S. E., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.00590 · Cited by 499
Ramanathan, R. K., McDonough, S. L., Philip, P. A., Hingorani, S. R., Lacy, J., Kortmansky, J. S., Thumar, J., Chiorean, E. G., Shields, A. F., Behl, D., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.18.01295 · Cited by 336
Microenvironmental Determinants of Pancreatic Cancer
Hessmann, E., Buchholz, S. M., Demir, I. E., Singh, S. K., Gress, T. M., Ellenrieder, V., & Neesse, A. (2020) · Physiological Reviews · doi:10.1152/physrev.00042.2019 · Cited by 331
Vennin, C., Mélénec, P., Rouet, R., Nobis, M., Cazet, A. S., Murphy, K. J., Herrmann, D., Reed, D. A., Lucas, M. C., Warren, S. C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10968-6 · Cited by 268
Self-citationA microfluidic-based PDAC organoid system reveals the impact of hypoxia in response to treatment
Geyer, M., Schreyer, D., Gaul, L.-M., Pfeffer, S., Pilarsky, C., & Queiroz, K. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01334-z · Cited by 61
Metadata
- Authors
- Vennin, C., Murphy, K. J., Morton, J. P., Cox, T. R., Pajic, M., & Timpson, P.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 154
- Issue
- 4
- Pages
- 820-838
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2778853355
- Cited by
- 202
- References
- 44
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Vennin, C., Murphy, K. J., Morton, J. P., Cox, T. R., Pajic, M., & Timpson, P. (2018). Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer. Gastroenterology. https://doi.org/10.1053/j.gastro.2017.11.280
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
