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Cited by 9Congenital gastrointestinal and neural anomaliesGastrointestinal motility and disordersDevelopmental Biology and Gene Regulation

Development of the Enteric Nervous System: A Genetic Guide to the Perplexed

Open access
Gershon, Michael D.·2018·Gastroenterology
DOI 10.1053/j.gastro.2018.01.012PMC PMC6252172
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Crossref · 10.1053/j.gastro.2018.01.012

Cites

1 of 1 references verified0 citation errors · 0 not checkable

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  • Dopamine is found in both the central and enteric nervous systems.

    “Further, the neurotransmitter dopamine is also found in both the central and enteric nervous systems (Gershon, 2018;Li et al., 2006).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Gershon, 2018

    The main text reports gastric dopaminergic neurons, supporting dopamine’s presence in the enteric nervous system. Its discussion of the CNS does not say that dopamine is found there, so this source supports only the enteric part of the claim. No page number is available in our copy. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • The ENS is believed to be more analogous to the CNS than other networks within the peripheral nervous system.

    “Due to the organization and structure of the number, morphology, and neurochemical nature of the ENS networks within the ANS, it is believed to be more analogous to the CNS than other networks within the peripheral nervous system (Gershon, 2018;Timmermans et al., 1997;Wood, 2008Wood, , 2016)).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Gershon, 2018

    The section “Development of the Enteric Nervous System: A Genetic Guide to the Perplexed” (page not provided) discusses ENS independence from CNS input and compares aspects of ENS and CNS development. It does not say that the ENS is more analogous to the CNS than other peripheral nervous system networks. Searches for that comparison and for similarities in neuronal organization and neurochemistry found no passage addressing it. (LLM, conf=0.72)

    Experimental — accuracy not yet measured

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Cites

Flagged first, then by citations

Research works printed but not linked: 20

  1. [1]Gross ER, Gershon MD, Margolis KG, Neuronal serotonin regulates growth of the intestinal mucosa in mice. Gastroenterology 2012; 143: 408– 417 e2. 22609381 PMC3687781
  2. [3]Margolis KG, Gershon MD. Enteric neuronal regulation of intestinal inflammation. Trends Neurosci 2016; 39: 614– 624. 27450201 PMC5002370
  3. [4]Margolis KG, Stevanovic K, Karamooz N, Enteric neuronal density contributes to the severity of intestinal inflammation. Gastroenterology 2011; 141: 588– 598. 21635893 PMC4459707
  4. [5]Trendelenburg P Physiologische und pharmakologische Versuche über die Dünndarm Peristaltick. Naunyn-Schmiedebergs Arch Exp Pathol Pharmakol 1917; 81: 55– 129. 17312568
  5. [6]Bern C Chagas’ disease. N Engl J Med 2015; 373: 456– 466. 26222561
  6. [7]Gershon AA, Chen J, Gershon MD. Use of Saliva to identify varicella zoster virus infection of the gut. Clin Infect Dis 2015; 61: 536– 544. 25882301 PMC4607733
  7. [8]Tam PK. Hirschsprung’s disease: a bridge for science and surgery. J Pediatr Surg 2016; 51: 18– 22. 26611330
  8. [9]Amiel J, Sproat-Emison E, Garcia-Barcelo M, Hirschsprung disease, associated syndromes and genetics: a review. J Med Genet 2008; 45: 1– 14. 17965226
  9. [10]Bondurand N, Southard-Smith EM. Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: old and new players. Dev Biol 2016; 417: 139– 157. 27370713 PMC5026931
  10. [11]Li Z, Chalazonitis A, Huang YY, Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. J Neurosci 2011; 31: 8998– 9009. 21677183 PMC4442094
  11. [12]Chalazonitis A, Tang AA, Shang Y, Homeodomain interacting protein kinase 2 regulates postnatal development of enteric dopaminergic neurons and glia via BMP signaling. J Neurosci 2011; 31: 13746– 13757. 21957238 PMC3395796
  12. [13]DΆutreaux F, Margolis KG, Roberts J, Expression level of Hand2 affects specification of enteric neurons and gastrointestinal function in mice. Gastroenterology 2011; 141: 576– 587. 21669203 PMC3152642
  13. [14]Gianino S, Grider JR, Cresswell J, GDNF availability determines enteric neuron number by controlling precursor proliferation. Development 2003; 130: 2187– 2198. 12668632
  14. [15]Puig I, Champeval D, De Santa Barbara P, Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction. J Clin Invest 2009; 119: 3586– 3596. 19884655 PMC2786803
  15. [16]Iwamuro M, Omote R, Tanaka T, Diffuse intestinal ganglioneuromatosis showing multiple large bowel ulcers in a patient with neurofibromatosis type 1. Intern Med 2017; 56: 3287– 3291. 29021449 PMC5790715
  16. [17]Gfroerer S, Theilen TM, Fiegel H, Identification of intestinal ganglioneuromatosis leads to early diagnosis of MEN2B: role of rectal biopsy. J Pediatr Surg 2017; 52: 1161– 1165. 27899172
  17. [18]Kapur RP. Does bcl2 immunostaining really help with pathological evaluation of intestinal pseudo-obstruction? Am J Surg Pathol 2006; 30: 1059 author reply 1059–62. 16861987
  18. [19]Toledo de Arruda Lourencao PL, Terra SA, Ortolan EV, Intestinal neuronal dysplasia type B: a still little known diagnosis for organic causes of intestinal chronic constipation. World J Gastrointest Pharmacol Ther 2016; 7: 397– 405. 27602240 PMC4986395
  19. [20]Gui H, Schriemer D, Cheng WW, Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. Genome Biol 2017; 18: 48. 28274275 PMC5343413
  20. [21]Memic F, Knoflach V, Morarach K, Transcription and signaling regulators in developing neuronal subtypes of mouse and human enteric nervous system. Gastroenterology 2018; 154: 624– 636 29031500 PMC6381388

Cited by

Sorted by citations

Authors
Gershon, M. D.
Affiliations
Columbia University Irving Medical Center (US)
Corresponding author
Gershon, Michael D.
ORCID
Gershon, Michael D.
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2018-02
Volume
154
Issue
3
Pages
478-480
ISSN
0016-5085 (ISSN-L)
DOI
10.1053/j.gastro.2018.01.012
PMC
PMC6252172
OpenAlex
W2783700968
Cited by
9
References
1
Citations by year
2025: 1 · 2022: 2 · 2020: 2 · 2019: 4
FWCI
1.56
Type
journal article
Language
en
Open access
Licence
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (DK093094, NS015547)
Topics
  • Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
enteric nervous system, enteric nervous system development, Hirschsprung disease, gastrointestinal motility, gastrointestinal secretion, gut-brain axis, intestinal immunity, gastrointestinal inflammation, pseudo-obstruction
MeSH terms
Humans, Neural Crest, Enteric Nervous System

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