Why Do So Many Nonalcoholic Steatohepatitis Trials Fail?
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Fascia fibroblasts gather surrounding extracellular matrix, including blood vessels, macrophages, and peripheral nerves, to form the provisional matrix, and their ablation inhibits matrix homing into wounds, causing defective scars.
“These fascia fibroblasts gather their surrounding extracellular matrix (including blood vessels, macrophages and peripheral nerves) to form the provisional matrix, and ablation of these fibroblasts inhibited matrix homing into wounds leading to defective scars.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [26]
Placing an impermeable film beneath the skin, which prevents upward migration of fascia fibroblasts, leads to chronic open wounds.
“Intriguingly, placement of an impermeable film beneath the skin (preventing upward migration of fascia fibroblasts) led to chronic open wounds.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [26]
A specialized subset of fibroblasts, fascia fibroblasts, rise to the surface of the skin after wounding.
“A combination of fate mapping and live imaging, revealed that a specialised subset of fibroblasts, fascia fibroblasts, rise to the surface of the skin following wounding26.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [26]
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References 56 · Cited by 88
Research works printed but not linked: 1
- 89bio Press Releases. 89bio's Phase 2b ENLIVEN trial of pego- zafermin in nonalcoholic steatohe- patitis (NASH) achieved high statistical significance on both pri- mary histology endpoints with weekly (QW) and every-two-week (Q2W) dosing at 24 weeks. Avail- able at: https://ir.89bio.com/news- releases/news-release-details/89bios- phase-2b-enliven-trial-pegozafermin- nonalcoholic. Accessed April 19, 2023.
- Authors
- Ratziu, V., & Friedman, S. L.
- Affiliations
- Inserm (FR)
- Icahn School of Medicine at Mount Sinai (US)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 165
- Issue
- 1
- Pages
- 5-10
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W3027827688
- Cited by
- 88
- References
- 56
- Citations by year
- 2026: 4 · 2025: 16 · 2024: 16 · 2023: 10 · 2022: 10 · 2021: 21 · 2020: 10
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- Pfizer
- Axcella Health
- Clade Therapeutics
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- nonalcoholic steatohepatitis, clinical trial failure, liver fibrosis, selonsertib, ASK1 inhibitors, IDN-6556, elafibranor, insulin sensitizers, drug development
- MeSH terms
- Clinical Trials as Topic, Humans, Non-alcoholic Fatty Liver Disease
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