CoChat
Sign Up
Cited by 270Gastrointestinal motility and disordersGastroesophageal reflux and treatmentsPsychosomatic Disorders and Their Treatments

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Functional Dyspepsia and Gastroparesis in Tertiary Care are Interchangeable Syndromes With Common Clinical and Pathologic Features

Open access
Pasricha, Pankaj J., Grover, Madhusudan, Yates, Katherine P., Abell, Thomas L., Bernard, Cheryl E., Koch, Kenneth L., McCallum, Richard W., Sarosiek, Irene, Kuo, Braden, Bulat, Robert, Chen, Jiande, Shulman, Robert J., Lee, Linda, Tonascia, James, Miriel, Laura A., Hamilton, Frank, Farrugia, Gianrico, Parkman, Henry P., Pasricha, Pankaj Jay, Bulat, Robert, Burns, Robert, Hernandez, Guillermo Barahona, McKnight, Megan, Kuo, Braden, Mendez, April, Staller, Kyle, Thurler, Andrea, Velez, Christopher, Silvernale, Casey, Parkman, Henry P., Malik, Zubair, Maurer, Alan, Palit, Amiya, McCallum, Richard W., Sarosiek, Irene, Vega, Natalia, Vasquez, Denise, Connery, Sean, Espino, Karina, Friedman, Marvin, Abell, Thomas, Stocker, Abigail, Cannon, Bridget, McElmurray, Lindsay, Cooper, Kelly, McBride, Catherine, Koch, Kenneth, Baxter, Lynn, Brown, Anya, Stuart, Paula, Abdullah, Amirah, Snape, William, DeVole, Nata, Earle, Karen, Kirkeby, Kjersti, Lee, Candice, Lin, Mimi, Troyer, Doug, von Bakonyi, Anna, Shulman, Robert, Chumpitazi, Bruno, Febo-Rodriguez, Liz, Hollier, John, Bouette, Cynthia, Charron, Heather, Nurko, Samuel, Wall, Stephanie, Kane, Madeline, Williams, Kent, Yossef-Salameh, Lina, Woodley, Frederick, Farrugia, Gianrico, Grover, Madhusudan, Bernard, Cheryl, Serrano, Jose, Hamilton, Frank, Hall, Sherry, James, Stephen, Torrance, Rebecca, Tonascia, James, Adamo, Margaret, Belt, Patricia, Dodge, John, Donithan, Michele, Isaacson, Milana, Lee, Linda, Meinert, Jill, Miriel, Laura, Sharkey, Emily, Smith, Jacqueline, Smith, Michael, Sternberg, Alice, Van Natta, Mark, Wagoner, Annette, Wilson, Laura, Yamada, Goro, Yates, Katherine·2021·Gastroenterology
DOI 10.1053/j.gastro.2021.01.230PMC PMC8547190
Open this paper in CoChat — free account

Abstract

Background The aim of this study was to clarify the pathophysiology of functional dyspepsia (FD), a highly prevalent gastrointestinal syndrome, and its relationship with the better-understood syndrome of gastroparesis. Methods Adult patients with chronic upper gastrointestinal symptoms were followed up prospectively for 48 weeks in multi-center registry studies. Patients were classified as having gastroparesis if gastric emptying was delayed; if not, they were labeled as having FD if they met Rome III criteria. Study analysis was conducted using analysis of covariance and regression models. Results Of 944 patients enrolled during a 12-year period, 720 (76%) were in the gastroparesis group and 224 (24%) in the FD group. Baseline clinical characteristics and severity of upper gastrointestinal symptoms were highly similar. The 48-week clinical outcome was also similar but at this time 42% of patients with an initial diagnosis of gastroparesis were reclassified as FD based on gastric-emptying results at this time point; conversely, 37% of patients with FD were reclassified as having gastroparesis. Change in either direction was not associated with any difference in symptom severity changes. Full-thickness biopsies of the stomach showed loss of interstitial cells of Cajal and CD206+ macrophages in both groups compared with obese controls. Conclusions A year after initial classification, patients with FD and gastroparesis, as seen in tertiary referral centers at least, are not distinguishable based on clinical and pathologic features or based on assessment of gastric emptying. Gastric-emptying results are labile and do not reliably capture the pathophysiology of clinical symptoms in either condition. FD and gastroparesis are unified by characteristic pathologic features and should be considered as part of the same spectrum of truly "organic" gastric neuromuscular disorders. CLINICALTRIALS. Gov identifier NCT00398801, NCT01696747.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1053/j.gastro.2021.01.230

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 19 references

Cited by

Sorted by citations

See all 270

Related

Metadata

Authors
Pasricha, P. J., Grover, M., Yates, K. P., Abell, T. L., Bernard, C. E., Koch, K. L., McCallum, R. W., Sarosiek, I., Kuo, B., Bulat, R., Chen, J., Shulman, R. J., Lee, L., Tonascia, J., Miriel, L. A., Hamilton, F., Farrugia, G., Parkman, H. P., Pasricha, P. J., Bulat, R., Burns, R., Hernandez, G. B., McKnight, M., Kuo, B., Mendez, A., Staller, K., Thurler, A., Velez, C., Silvernale, C., Parkman, H. P., Malik, Z., Maurer, A., Palit, A., McCallum, R. W., Sarosiek, I., Vega, N., Vasquez, D., Connery, S., Espino, K., Friedman, M., Abell, T., Stocker, A., Cannon, B., McElmurray, L., Cooper, K., McBride, C., Koch, K., Baxter, L., Brown, A., Stuart, P., Abdullah, A., Snape, W., DeVole, N., Earle, K., Kirkeby, K., Lee, C., Lin, M., Troyer, D., von Bakonyi, A., Shulman, R., Chumpitazi, B., Febo-Rodriguez, L., Hollier, J., Bouette, C., Charron, H., Nurko, S., Wall, S., Kane, M., Williams, K., Yossef-Salameh, L., Woodley, F., Farrugia, G., Grover, M., Bernard, C., Serrano, J., Hamilton, F., Hall, S., James, S., Torrance, R., Tonascia, J., Adamo, M., Belt, P., Dodge, J., Donithan, M., Isaacson, M., Lee, L., Meinert, J., Miriel, L., Sharkey, E., Smith, J., Smith, M., Sternberg, A., Van Natta, M., Wagoner, A., Wilson, L., Yamada, G., & Yates, K.
Affiliations
  • Baylor College of Medicine (US)
  • Massachusetts General Hospital (US)
  • Temple University (US)
  • Texas Tech University (US)
  • University of Louisville (US)
  • Wake Forest University (US)
  • Johns Hopkins University (US)
  • Mayo Clinic (US)
ORCID
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2021-05
Volume
160
Issue
6
Pages
2006-2017
ISSN
0016-5085 (ISSN-L)
DOI
10.1053/j.gastro.2021.01.230
PMC
PMC8547190
OpenAlex
W3128851695
Cited by
268
References
19
Citations by year
2026: 47 · 2025: 52 · 2024: 44 · 2023: 60 · 2022: 37 · 2021: 28
FWCI
37.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIDDK
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
functional dyspepsia, gastroparesis, gastric emptying, interstitial cells of Cajal, CD206+ macrophages, gastric mucosa, upper gastrointestinal symptoms, Rome III criteria, tertiary care hospital patients
MeSH terms
Adult, Dyspepsia, Female, Gastric Emptying, Humans, Male, Middle Aged, Nausea, Registries, Severity of Illness Index, Stomach, Vomiting, Abdominal Pain, Case-Control Studies, Gastroparesis, Interstitial Cells of Cajal, Tertiary Care Centers, Symptom Assessment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review