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Altered Mycobiota Signatures and Enriched Pathogenic Aspergillus rambellii Are Associated With Colorectal Cancer Based on Multicohort Fecal Metagenomic Analyses
Open accessAbstract
BACKGROUND & AIMS: The enteric mycobiota is a major component of the human gut microbiota, but its role in colorectal cancer (CRC) remains largely elusive. We conducted a meta-analysis to uncover the contribution of the fungal mycobiota to CRC. METHODS: We retrieved fecal metagenomic data sets from 7 previous publications and established an additional in-house cohort, totaling 1329 metagenomes (454 with CRC, 350 with adenoma, and 525 healthy individuals). Mycobiota composition and microbial interactions were analyzed. Candidate CRC-enriched fungal species (Aspergillus rambellii) was functionally validated in vitro and in vivo. RESULTS: Multicohort analysis revealed that the enteric mycobiota was altered in CRC. We identified fungi that were associated with patients with CRC or adenoma from multiple cohorts. Signature CRC-associated fungi included 6 enriched (A rambellii, Cordyceps sp. RAO-2017, Erysiphe pulchra, Moniliophthora perniciosa, Sphaerulina musiva, and Phytophthora capsici) and 1 depleted species (A kawachii). Co-occurrent interactions among CRC-enriched fungi became stronger in CRC compared with adenoma and healthy individuals. Moreover, we reported the transkingdom interactions between enteric fungi and bacteria in CRC progression, of which A rambellii was closely associated with CRC-enriched bacteria Fusobacterium nucleatum. A rambellii promoted CRC cell growth in vitro and tumor growth in xenograft mice. We further identified that combined fungal and bacterial biomarkers were more accurate than panels with pure bacterial species to discriminate patients with CRC from healthy individuals (the area under the curve relative change increased by 1.44%-10.60%). CONCLUSIONS: This study reveals enteric mycobiota signatures and pathogenic fungi in stages of colorectal tumorigenesis. Fecal fungi can be used, in addition to bacteria, for noninvasive diagnosis of patients with CRC.
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“Studies have discovered specific virome79 and mycobiome86,87 signatures for CRC GOMS, and included in vitro and in vivo experiments showing that the fungus Aspergillus rambellii can promote CRC cell growth86.”
From Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy (2023) · cites this paper as [86]
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Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Receiver Operating Characteristic Curve in Diagnostic Test Assessment
Mandrekar, J. N. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181ec173d · Cited by 4,506
Environment dominates over host genetics in shaping human gut microbiota
Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., Costea, P. I., Godneva, A., Kalka, I. N., Bar, N., et al. (2018) · Nature · doi:10.1038/nature25973 · Cited by 2,859
Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy
Yu, T., Guo, F., Yu, Y., Sun, T., Ma, D., Han, J., Qian, Y., Kryczek, I., Sun, D., Nagarsheth, N., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.008 · Cited by 2,198
Self-citationGut microbiome development along the colorectal adenoma-carcinoma sequence
Feng, Q., Liang, S., Jia, H., Stadlmayr, A., Tang, L., Lan, Z., Zhang, D., Xia, H., Xu, X., Jie, Z., et al. (2015) · Nature Communications · doi:10.1038/ncomms7528 · Cited by 1,506
Yachida, S., Mizutani, S., Shiroma, H., Shiba, S., Nakajima, T., Sakamoto, T., Watanabe, H., Masuda, K., Nishimoto, Y., Kubo, M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0458-7 · Cited by 1,429
Gut microbiota in colorectal cancer: mechanisms of action and clinical applications
Wong, S. H., & Yu, J. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0209-8 · Cited by 1,392
Self-citationPotential of fecal microbiota for early-stage detection of colorectal cancer
Zeller, G., Tap, J., Voigt, A. Y., Sunagawa, S., Kultima, J. R., Costea, P. I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N., et al. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145645 · Cited by 1,375
Wirbel, J., Pyl, P. T., Kartal, E., Zych, K., Kashani, A., Milanese, A., Fleck, J. S., Voigt, A. Y., Palleja, A., Ponnudurai, R., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0406-6 · Cited by 1,373
Research works printed but not linked: 1
- Schulze, 2009, Yeasts in the gut: from commensals to infectious agents, Dtsch Arztebl Int, 106, 837
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Self-citationGut Microbiota in Colorectal Cancer: Biological Role and Therapeutic Opportunities
Pandey, H., Tang, D. W. T., Wong, S. H., & Lal, D. (2023) · Cancers · doi:10.3390/cancers15030866 · Cited by 171
Self-citationGut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy
Thomas, A. M., Fidelle, M., Routy, B., Kroemer, G., Wargo, J. A., Segata, N., & Zitvogel, L. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00785-8 · Cited by 141
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Li, S., Zhu, S., & Yu, J. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.11.027 · Cited by 109
Self-citationPardini, B., Ferrero, G., Tarallo, S., Gallo, G., Francavilla, A., Licheri, N., Trompetto, M., Clerico, G. F., Senore, C., Peyre, S., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.05.037 · Cited by 80
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Implications of gut microbiota-mediated epigenetic modifications in intestinal diseases
Zhang, Q., Liu, Y., Li, Y., Bai, G., Pang, J., Wu, M., Li, J., Zhao, X., & Xia, Y. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2508426 · Cited by 73
Self-citationLin, Y., Xie, M., Lau, H. C.-H., Zeng, R., Zhang, R., Wang, L., Li, Q., Wang, Y., Chen, D., Jiang, L., et al. (2024) · Med · doi:10.1016/j.medj.2024.10.007 · Cited by 66
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Emerging clinical relevance of microbiome in cancer: promising biomarkers and therapeutic targets
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Huang, Z., Liu, K., Ma, W., Li, D., Mo, T., & Liu, Q. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1018594 · Cited by 68
Lin, Y., Lau, H. C.-H., Liu, C., Ding, X., Sun, Y., Rong, J., Zhang, X., Wang, L., Yuan, K., Miao, Y., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.03.012 · Cited by 42
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Self-citationDing, T., Liu, C., & Li, Z. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02227-8 · Cited by 44
Self-citationChen, C., Su, Q., Zi, M., Hua, X., & Zhang, Z. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00818-3 · Cited by 45
The microbiome and rise of early-onset cancers: knowledge gaps and research opportunities
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Gao, S., Gao, X., Zhu, R., Wu, D., Feng, Z., Jiao, N., Sun, R., Gao, W., He, Q., Liu, Z., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2221428 · Cited by 40
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Gut fungal mycobiome: A significant factor of tumor occurrence and development
Li, F., Gao, Y., Cheng, W., Su, L., & Yang, R. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216302 · Cited by 36
Gao, W., Gao, X., Zhu, L., Gao, S., Sun, R., Feng, Z., Wu, D., Liu, Z., Zhu, R., & Jiao, N. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2245562 · Cited by 34
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Zhang, Z., Chen, Y., Pan, X., Li, P., Ren, Z., Wang, X., Chen, Y., Shen, S., Wang, T., & Lin, A. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01771-y · Cited by 26
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Spirito, F. D., Palo, M. P. D., Folliero, V., Cannatà, D., Franci, G., Martina, S., & Amato, M. (2023) · Cancers · doi:10.3390/cancers15235540 · Cited by 23
Zhu, X., Xu, P., Zhu, R., Gao, W., Yin, W., Lan, P., Zhu, L., & Jiao, N. (2024) · Communications Biology · doi:10.1038/s42003-023-05714-0 · Cited by 25
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Self-citationLiu, Q., Zhang, W., Pei, Y., Tao, H., Ma, J., Li, R., Zhang, F., Wang, L., Shen, L., Liu, Y., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-03095-z · Cited by 21
Self-citationLi, L., Huang, X., & Chen, H. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2328868 · Cited by 21
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Self-citationHu, M., Zhu, X., Huang, X., Li, H., Lin, X., Zhang, H., Hu, Y., Tong, T., Li, L., Xuan, B., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115589 · Cited by 20
Oral mycobiota and pancreatic ductal adenocarcinoma
Wei, A., Zhao, H., Cong, X., Wang, L., Chen, Y., Gou, J., Hu, Z., Hu, X., Tian, Y., Li, K., et al. (2022) · BMC Cancer · doi:10.1186/s12885-022-10329-5 · Cited by 18
The mycobiome: interactions with host and implications in diseases
Fan, Y., Wu, L., & Zhai, B. (2023) · Current Opinion in Microbiology · doi:10.1016/j.mib.2023.102361 · Cited by 17
Han, W., Wang, N., Han, M., Liu, X., Sun, T., & Xu, J. (2023) · Cancer Medicine · doi:10.1002/cam4.6503 · Cited by 17
Fungi, immunosenescence and cancer
Xu, B., Luo, Z., Niu, X., Li, Z., Lu, Y., & Li, J. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.01.002 · Cited by 17
Wu, D., Wang, A., Bu, D., Sun, Y., Li, C., Hong, Y.-M., Zhang, S., Chen, S., Zhou, J., Zhang, T., et al. (2025) · iMeta · doi:10.1002/imt2.70090 · Cited by 16
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Zhou, Z., Kleis, L., Depetris-Chauvin, A., Jaskulski, S., Damerell, V., Michels, K. B., Gigic, B., Nöthlings, U., & Panagiotou, G. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00177-0 · Cited by 23
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Chen, Y., Li, W., Chang, E. T., Debelius, J. W., Manoharan, L., Zheng, Y., Li, Y., Huang, G., Adami, H., Knight, R. D., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104813 · Cited by 15
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Kiran, N. S., Chatterjee, A., Yashaswini, C., Deshmukh, R., Alsaidan, O. A., Bhattacharya, S., & Prajapati, B. G. (2025) · Medical Oncology · doi:10.1007/s12032-025-02761-x · Cited by 15
Li, X., Wu, D., Li, Q., Gu, J., Gao, W., Zhu, X., Yin, W., Zhu, R., Zhu, L., & Jiao, N. (2023) · Physiological Genomics · doi:10.1152/physiolgenomics.00103.2023 · Cited by 15
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He, Y., Peng, K., Tan, J., Hao, Y., Zhang, S., Gao, C., & Li, L. (2025) · Nutrients · doi:10.3390/nu17223552 · Cited by 15
Oral Fungal Alterations in Patients with COVID‐19 and Recovered Patients
Hu, X., Wang, H., Yu, B., Yu, J. Y., Lu, H., Sun, J., Sun, Y., Zou, Y., Luo, H., Zeng, Z., et al. (2023) · Advanced Science · doi:10.1002/advs.202205058 · Cited by 13
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Self-citation“Nutrient–fungi–host” tripartite interaction in cancer progression
Wu, D., Guan, Y., Li, C., Zheng, Q., Yin, Z., Wang, H., & Liu, N. (2024) · iMeta · doi:10.1002/imt2.170 · Cited by 13
He, X., Zhao, Q., Zhang, J., Shi, J., Wan, N., Tang, B., Tian, B., & Li, P. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1652702 · Cited by 12
Ibeanu, G. C., Rowaiye, A. B., Okoli, J., & Eze, D. (2024) · ImmunoTargets and Therapy · doi:10.2147/itt.s486731 · Cited by 12
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Zhang, W., Zhang, H., Gao, Y., Lei, J., & Suo, C. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1596688 · Cited by 14
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Self-citationProgress of gut microbiome and its metabolomics in early screening of colorectal cancer
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Self-citationWang, A.-J., Song, D., Hong, Y.-M., & Liu, N. (2023) · Molecular Omics · doi:10.1039/d2mo00288d · Cited by 9
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Fungal influence on immune cells and inflammatory responses in the tumor microenvironment (Review)
Zhang, J., Feng, Y., Li, D., & Shi, D. (2024) · Oncology Letters · doi:10.3892/ol.2024.14796 · Cited by 9
Fungal Influences on Cancer Initiation, Progression, and Response to Treatment
Bilal, H., Khan, M. N., Khan, S., Shafiq, M., Fang, W., Zeng, Y., Guo, Y., Li, X., Zhao, B., Lv, Q., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-1609 · Cited by 10
Brain Tumors and Beyond: Multi-Compartment Microbiome and Mycobiome Analysis
Sípos, L., Banczerowski, P., Juhász, J., Fedorcsák, I., Berényi, G., Makra, N., Dunai, Z. A., Szabó, D., & Erőss, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26030991 · Cited by 9
Zheng, Q., Zhong, Y., Lian, H., Zhuang, J., Wang, L., Chen, J., Wang, H., Wang, H., Ye, X., Huang, Z., et al. (2025) · United European Gastroenterology Journal · doi:10.1002/ueg2.70064 · Cited by 8
Research progress on the correlation between intestinal flora and colorectal cancer
Wang, X., Zhang, Q., Xu, R., Li, X., & Hong, Z. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1416806 · Cited by 7
The bidirectional effects and mechanisms of the oral and gut microbiomes: a narrative review
Huo, T., Huang, X., Liao, J., Zhang, H., Hu, L., & Xie, M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1697413 · Cited by 8
Han, B. R., Zhang, Y., Feng, X., Yang, J. J. J., Wang, B., Fang, J., Wang, Z., Zhu, J., Niu, G., & Guo, Y. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1563886 · Cited by 7
Zhou, X., Sun, H. J., Ren, J., Yan, G., Yang, L., Zhang, H., Lu, H., Li, X., Makino, T., Yin, F., et al. (2024) · MedComm · doi:10.1002/mco2.556 · Cited by 7
Changes of gut mycobiota in the third trimester of pregnant women with preeclampsia
Zou, H., Zou, W., Li, Q., Chen, Z., Shi, Y., & Li, C. (2023) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2023.2228964 · Cited by 6
Measuring gut microbiome as a colorectal cancer screening tool: potential and challenges
Severino, A., Marchitto, S. A., Bisegna, P., Porcari, S., Rondinella, D., Schepis, T., Barbaro, F., Pecere, S., Maida, M. F., Spada, C., et al. (2025) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2025.2592078 · Cited by 6
Update on the role of mycobiome in Gastrointestinal cancers: mechanisms and therapeutic implications
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Chai, Z., Zhang, H., Ji, X., Hu, X., He, Y., Zhao, F., Song, C., Zhou, Y., Li, T., He, C., et al. (2024) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2024.102643 · Cited by 5
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Zhao, M.-Q., Fan, M.-Y., Cui, M.-Y., Chen, S., Wang, J.-J., Lü, Y., & Jiang, Q. (2025) · Gut Pathogens · doi:10.1186/s13099-024-00675-z · Cited by 5
Zhang, L., Zhou, D., Feng, J., Liao, Z.-J., Shu, X.-L., Yang, R., Gao, Y., Zhou, H., Zhang, W., Zou, Y. F., et al. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00827-2 · Cited by 4
Bronchoalveolar lavage fluid (BALF): Clinical applications for present and future
Mei, J., Chen, Y.-S., Tian, H., Wang, L., Zeng, J., Wang, L., Rong, D., Wong, R. C. B., Gao, Y., Guo, C., et al. (2025) · The Innovation Medicine · doi:10.59717/j.xinn-med.2025.100115 · Cited by 4
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Visual analysis of colorectal cancer and gut microbiota: A bibliometric analysis from 2002 to 2022
Long, D., Mao, C., Zhang, Z., Zou, J., & Zhu, Y. (2023) · Medicine · doi:10.1097/md.0000000000035727 · Cited by 4
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Li, J., Ma, C., Liu, X., Jiang, S., Huo, D., Cai, K., & Zhang, J. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105615 · Cited by 4
Khannous‐Lleiffe, O., & Gabaldón, T. (2025) · Research Square · doi:10.21203/rs.3.rs-6766778/v1 · Cited by 4
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Li, J., Liu, L., Zhong, X. Y., & Yang, R. (2025) · Postgraduate Medical Journal · doi:10.1093/postmj/qgaf026 · Cited by 3
Chen, L., Ruan, G., Zhao, X., Yi, A., Xiao, Z., Tian, Y., Cheng, Y., Chen, D., & Wei, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1553757 · Cited by 3
Canderan, J., & Ye, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-97984-3 · Cited by 3
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Hong, Y.-M., Song, D., Liu, N., & Wang, H. (2023) · Aging and Cancer · doi:10.1002/aac2.12063 · Cited by 3
Chen, H., Zeng, Y., Cai, G. X., Gu, W., & Yang, Y. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1323842 · Cited by 3
Liu, M., He, S.-Y., Li, Y., Shen, J., Li, J., Li, J., Liu, Y., Wu, T., Li, J., & Hu, L. Q. (2025) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2025.102837 · Cited by 3
Self-citationZhang, H., & Zhai, B. (2025) · Current topics in microbiology and immunology · doi:10.1007/82_2025_315 · Cited by 2
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Huang, R., Su, X., Wang, J., Sun, Q., Kang, D., Li, L., Wu, Y., Zhao, L., Xie, Z., & Zou, Z. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-011097 · Cited by 2
Chu, X., Wang, Z., Cheng, S., Khan, A., Dong, N., Xie, S., Zheng, Q., Yang, P., & Shen, H. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.108000 · Cited by 2
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Fu, Q., Zhao, N., Li, X., Li, Y., Tian, T., Gao, L., Cao, Y., Wang, L., Liu, J., Wang, F., et al. (2025) · mSystems · doi:10.1128/msystems.01146-25 · Cited by 2
Self-citation
Metadata
- Authors
- Lin, Y., Lau, H. C.-H., Liu, Y., Kang, X., Wang, Y., Ting, N. L.-N., Kwong, T. N.-Y., Han, J., Liu, W., Liu, C., She, J., Wong, S. H., Sung, J. J.-Y., & Yu, J.
- Affiliations
- Chinese University of Hong Kong (HK)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Nanyang Technological University (SG)
- Corresponding author
- Yu, Jun
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2022-10
- Volume
- 163
- Issue
- 4
- Pages
- 908-921
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W4283075856
- Cited by
- 142
- References
- 38
- Citations by year
- 2026: 27 · 2025: 41 · 2024: 29 · 2023: 41 · 2022: 4
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Gastroenterology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion, cc-by-nc-nd)
- Funders
- The Chinese University of Hong Kong
- National Key Research and Development Program of China (2020YFA0509200/2020YFA0509203)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Mycorrhizal Fungi and Plant Interactions
- Keywords
- colorectal cancer, colorectal adenoma, Fusobacterium nucleatum, fungal-bacterial interactions, colorectal carcinogenesis, non-invasive diagnosis, fecal biomarkers, Cordyceps, Moniliophthora perniciosa, Phytophthora capsici, Aspergillus kawachii
- MeSH terms
- Adenoma, Animals, Aspergillus, Bacteria, Cell Transformation, Neoplastic, Feces, Humans, Colorectal Neoplasms, Biomarkers, Mice, Metagenome
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