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Cited by 19Dialysis and Renal Disease ManagementChronic Kidney Disease and DiabetesAcute Kidney Injury Research

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Positive Effects of Protein Restriction in Patients With Chronic Kidney Disease

Eyre, Sintra, Attman, Per-Ola, Haraldsson, Börje·2008·Journal of Renal Nutrition
DOI 10.1053/j.jrn.2007.11.013
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Abstract

Objectives The potential benefit or harm of low-protein diets (LPDs) for patients with chronic kidney disease has been debated. This study sought to investigate the effects of treatment with LPDs on nutritional markers, morbidity, and survival during subsequent dialysis. A second objective was to evaluate the effect of LPDs on renal function and the start of dialysis. Design This was a retrospective study of medical records. Setting The setting was an outpatient nephrology and dialysis clinic. Patients One-hundred twenty-two renal patients were recruited from the central dialysis registry of one clinic. The patients had been followed by a nephrologist for > or =6 months before dialysis. Sixty-one patients were treated with LPDs, and an equal number of control patients not treated with LPDs were matched for sex, age, dialysis modality, diabetes, and start of dialysis. Main outcome measures Main outcome measures included weight and weight change, serum albumin, glomerular filtration rate, morbidity, and mortality. Results There was less mean weight loss in the LPD group the year before dialysis (0.14 kg/month, compared with the control group at 0.36 kg/month, P < .05). The level of serum albumin was higher in the LPD group at the start of dialysis (P < .01). The mean rate of progression during the 6 months before dialysis was lower in the LPD group (4.1 mL/min/year) than in the control group (13.4 mL/min/year) (P < .001). The LPD group had fewer days of hospitalization at the start of dialysis than the control group (8.2 vs 15.4 days, respectively, P < .01). There was no difference in mortality between groups 1, 2, or 5 years after starting dialysis. Conclusions Low-protein diets can reduce patient morbidity, preserve renal function, relieve uremic symptoms and improve nutritional status. The results suggest that LPDs can postpone the start of dialysis for 6 months, and entail substantial cost-savings. Low-protein diets should be used more generally in the renal community.

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Crossref · 10.1053/j.jrn.2007.11.013

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Metadata

Authors
Eyre, S., Attman, P.-O., & Haraldsson, B.
Affiliations
University of Gothenburg (SE)
Corresponding author
Eyre, Sintra
ORCID
Venue
Journal of Renal Nutrition
Publisher
Elsevier BV
Published
2008-05
Volume
18
Issue
3
Pages
269-280
ISSN
1051-2276 (ISSN-L)
DOI
10.1053/j.jrn.2007.11.013
OpenAlex
W2084809731
Cited by
18
References
36
Citations by year
2026: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2016: 2 · 2014: 2 · 2013: 2 · 2012: 4
FWCI
0.51
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Renal Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
Keywords
low-protein diet, chronic kidney disease, dialysis initiation, renal function progression, glomerular filtration rate, serum albumin, weight loss, nutritional status, hospitalization, mortality, cost reduction
MeSH terms
Adult, Aged, Aged, 80 and over, Dietary Proteins, Female, Follow-Up Studies, Glomerular Filtration Rate, Renal Dialysis, Humans, Kidney Failure, Chronic, Male, Middle Aged, Nutritional Status, Retrospective Studies, Serum Albumin, Time Factors, Biomarkers, Treatment Outcome, Disease Progression, Diet, Protein-Restricted

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.