NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome

Chitturi, Shivakumar; Abeygunasekera, Shehan; Farrell, Geoffrey C.; Holmes-Walker, Jane; Hui, Jason M.; Fung, Caroline; Karim, Rooshdiya; Lin, Rita; Samarasinghe, Dev; Liddle, Christopher; Weltman, Martin; George, Jacob

doi:10.1053/jhep.2002.30692

NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome

Nonalcoholic steatohepatitis (NASH) is often linked with disorders that are clearly associated with insulin resistance (IR): obesity, type 2 diabetes mellitus, and hypertriglyceridemia. We tested the hypotheses that (1) IR is an essential requirement for the development of NASH and (2) a high ass…