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Cited by 92Osteoarthritis Treatment and MechanismsRheumatoid Arthritis Research and TherapiesGout, Hyperuricemia, Uric Acid

Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis

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Vilı́m, V., Vytášek, R., Olejárová, M., Macháček, S., Gatterová, J., Procházka, B., Kraus, V.B., Pavelka, K.·2001·Osteoarthritis and Cartilage
DOI 10.1053/joca.2001.0434
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Abstract

Objective Cartilage oligomeric matrix protein (COMP) is a component of articular cartilage whose serum levels show a strong correlation with radiographic osteoarthritis (OA) status. It has recently been found, however, that COMP is also produced in synovium. To assess the hypothesis that synovitis affects serum COMP levels in patients with knee OA, we collected sera for COMP simultaneous with a clinical examination for synovitis. Design Sera were collected from OA patients who fulfilled the American College of Rheumatology criteria for knee OA. Radiographs were classified according to the grading system of Kellgren and Lawrence. Synovitis was diagnosed clinically by joint tenderness plus swelling and/or increased warmth over the joint. COMP levels in sera were measured by inhibition ELISA with monoclonal antibody (mAb) 17-C10. Results Serum COMP levels were significantly correlated with age, synovitis and an interaction of synovitis and OA severity. Synovitis showed the strongest effect on COMP levels (R=0.1587, P< 0.01), in contrast to C-reactive protein, duration of OA and OA severity score which showed no significant effect on COMP levels. Individual signs of synovitis, namely, joint tenderness and warmth had a significant effect on serum COMP levels while swelling alone did not. Conclusion Synovitis exerts a significant effect on serum COMP levels measured with mAb 17-C10 in OA patients. These findings underscore the importance of the clinical joint examination to assess for synovitis, when attempting to apply objective measures, such as COMP, to the clinical setting.

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  • COMP is a 524 kDa non-collagenous glycoprotein that can be a beneficial biomarker.

    “COMP, a 524 kDa non-collagenous glycoprotein that can also be a beneficial biomarker [26].”

    From Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease (2025) · cites this paper as [26]

    The Introduction (page unavailable) calls COMP a non-collagenous glycoprotein of high molecular weight (>500 kDa) and a promising candidate biomarker for osteoarthritis. It does not give the specific molecular weight of 524 kDa. The Discussion (page unavailable) also cautions that serum COMP cannot discriminate between individual patients with and without synovitis. (LLM, conf=0.88)

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Research works printed but not linked: 39

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Cited by

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Authors
Vilı́m, V., Vytášek, R., Olejárová, M., Macháček, S., Gatterová, J., Procházka, B., Kraus, V. B., & Pavelka, K.
Affiliations
  • Institute of Rheumatology (CZ)
  • Duke University (US)
Corresponding author
Vilı́m, V.
ORCID
Venue
Osteoarthritis and Cartilage
Publisher
Elsevier BV
Published
2001-10
Volume
9
Issue
7
Pages
612-618
ISSN
1063-4584 (ISSN-L)
DOI
10.1053/joca.2001.0434
OpenAlex
W2068149217
Cited by
92
References
0
Citations by year
2025: 2 · 2024: 5 · 2022: 1 · 2021: 3 · 2019: 2 · 2018: 1 · 2017: 6 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 1 · 2012: 8
FWCI
3.30
Type
journal article
Language
en
Open access
Licence
Locations
  • Osteoarthritis and Cartilage (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (5P60-AG11268, AG 15108, R29AG015108, P60AG011268)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
Keywords
cartilage oligomeric matrix protein, synovitis, knee osteoarthritis, serum biomarkers, synovium, joint tenderness, joint swelling, C-reactive protein, Kellgren-Lawrence grade
MeSH terms
Adult, Age Factors, Aged, Analysis of Variance, Antibodies, Monoclonal, C-Reactive Protein, Enzyme-Linked Immunosorbent Assay, Female, Glycoproteins, Humans, Male, Middle Aged, Sensitivity and Specificity, Severity of Illness Index, Synovitis, Biomarkers, Confidence Intervals, Normal Distribution, Linear Models, Extracellular Matrix Proteins, Statistics, Nonparametric, Osteoarthritis, Knee, Matrilin Proteins, Cartilage Oligomeric Matrix Protein

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