A developmental and neurobiological approach to early trauma research
Abstract
Basic and clinical research documents associations between stress and a set of related psychobiologic perturbations, including dysfunction of the hypothalamic-pituitary-adrenal axis, alterations in the structure and function of the medial temporal lobe, and impairments in explicit memory. Although these associations are thought to emerge developmentally, insufficient clinical research elucidates the manner in which early trauma relates to these abnormalities. To gain a better understanding of relevant processes, we propose the use of a developmental and neurobiological approach, where data in animal models are used to inform studies in traumatized children who will be followed longitudinally. This approach will help clarify how early traumatic events have the capacity to lead to psychopathology or a healthy outcome.
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The timing of stress and its interactions with dynamic developmental processes are critical to subsequent outcomes.
“The timing of stress and its interactions with dynamic developmental processes are critical to subsequent outcomes (e.g., Lupien et al., 2009, Monk, 2008, Monk et al., 2002, Pechtel and Pizzagalli, 2011, Eiland and Romeo, 2013).”
From The impact of developmental timing for stress and recovery (2015) · cites this paper as Monk et al., 2002, Pechtel and Pizzagalli, 2011, Eiland and Romeo, 2013
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The impact of developmental timing for stress and recovery
Gee, D. G., & Casey, B. J. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2015.02.001 · Cited by 245 · see citing works
“The timing of stress and its interactions with dynamic developmental processes are critical to subsequent outcomes (e.g., Lupien et al., 2009; Monk, 2008; Monk et al., 2002; Pechtel and Pizzagalli, 2011; Eiland and Romeo, 2013).”
Background
- Authors
- Monk, C. S., Pine, D. S., & Charney, D. S.
- Affiliations
- National Institutes of Health (US)
- Venue
- Seminars in Clinical Neuropsychiatry
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 7
- Issue
- 2
- Pages
- 137-146
- ISSN
- 1084-3612 (ISSN-L)
- OpenAlex
- W2069599286
- Cited by
- 6
- References
- 0
- Citations by year
- 2015: 1
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Clinical Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- early childhood trauma, developmental trauma, hypothalamic-pituitary-adrenal axis, stress, medial temporal lobe, declarative memory, longitudinal follow-up, psychopathology, neurobiology of stress
- MeSH terms
- Adult, Animals, Anti-Inflammatory Agents, Brain, Child, Dexamethasone, Humans, Hypothalamo-Hypophyseal System, Magnetic Resonance Imaging, Pituitary-Adrenal System, Stress Disorders, Post-Traumatic
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