Jejunal Factor Stimulating Insulin Release in the Isolated Perfused Canine Pancreas and Jejunum
Abstract
In the present study using an isolated perfused preparation of canine jejunum and pancreas, an insulin-releasing factor was found in the venous effluent of the jejunum. Insulin secretion by the pancreas rose twofold after 10% glucose was infused in the lumen of the jejunum and remained at a high level even after the stimulus was discontinued. No modification of the exocrine pancreatic secretion occurred during the insulin release, and therefore it seems unlikely that gastrin, secretin or cholecystokinin-pancreozymin were released by the jejunal mucosa. In control experiments the values of hyperglycaemia observed previously and intraluminal hyperosmolarity were tested: at these levels, they did not affect insulin secretion. The nature of this intestinal insulin-releasing factor remains unknown however, but may be identifiable when intestinal hormones in blood can be assayed reliably.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Rapid delivery of undigested carbohydrates to the small intestine results in high glucose concentrations that induce a hyperinsulinemic response, resulting in subsequent hypoglycemia and related late dumping symptoms.
“Rapid delivery of undigested carbohydrates to the small intestine results in high glucose concentrations that induce a hyperinsulinemic response, resulting in subsequent hypoglycemia and related late dumping symptoms (28).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [28]
Cited by
Sorted by citations
Pathophysiology, diagnosis and management of postoperative dumping syndrome
Tack, J., Arts, J., Caenepeel, P., De Wulf, D., & Bisschops, R. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.148 · Cited by 387 · see citing works
“Under 'normal' conditions, the presence of glucose in the jejunum is a strong stimulus for insulin secretion; the rapid delivery of carbohydrates to the small intestine in dumping syndrome, therefore, causes excessive insulin secretion that subsequently results in hypoglycemia”
Backgroundvan Beek, A. P., Emous, M., Laville, M., & Tack, J. (2017) · Obesity Reviews · doi:10.1111/obr.12467 · Cited by 288 · see citing works
“Rapid delivery of undigested carbohydrates to the small intestine results in high glucose concentrations that induce a hyperinsulinemic response, resulting in subsequent hypoglycemia and related late dumping symptoms (28).”
BackgroundImpact of Postprandial Hypoglycemia on Weight Loss After Bariatric Surgery
Rebelos, E., Moriconi, D., Scalese, M., Denoth, F., Molinaro, S., Siciliano, V., Anselmino, M., Taddei, S., Ferrannini, E., & Nannipieri, M. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04465-9 · Cited by 35 · see citing works
Gastroparesis and Dumping Syndrome: Current Concepts and Management
Vavricka, S. R., & Greuter, T. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081127 · Cited by 37 · see citing works
Secretion of an insulinotropic factor from isolated, perfused rat intestine.
Levin, S., Pehlevanian, M., Lavee, A., & Adachi, R. (1979) · American Journal of Physiology · doi:10.1152/ajpendo.1979.236.6.e710 · Cited by 27 · see citing works
Bataille, D., Jarrousse, C., Vauclin, N., Gespach, C., & Rosselin, G. (1977) · Springer eBooks · doi:10.1007/978-1-4612-6366-1_19 · Cited by 16 · see citing works
The effects of bilio-jejunal diversion on streptozotocin diabetes in the rat
Ermini, M., Iaconis, E., & Mori, A. (2007) · Acta Diabetologica · doi:10.1007/bf02732117 · Cited by 9 · see citing works
Gys, B., Plaeke, P., Lamme, B., Lafullarde, T., Komen, N., Beunis, A., & Hubens, G. (2019) · Obesity Surgery · doi:10.1007/s11695-019-03818-3 · Cited by 8 · see citing works
[Dumping syndrome: Diagnostics and therapeutic options].
Seyfried, F., Wierlemann, A., Bala, M., Faßnacht, M., & Jurowich, C. F. (2015) · PubMed · doi:10.1007/s00104-015-0047-3 · Cited by 4 · see citing works
Kanazawa, K., Ito, T., Hijikata, M., & Kuwabara, K. (2024) · Cureus · doi:10.7759/cureus.75195 · Cited by 1 · see citing works
Treatment of Obesity with Bariatric Surgery
Izaguirre, M., Frühbeck, G., & Catalán, V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65164-4 · Cited by 2 · see citing works
- Authors
- Eloy, R., Garaud, J., Moody, A., Jaeck, D., & Grenier, J.
- Affiliations
- Inserm (FR)
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 1975
- Volume
- 7
- Issue
- 06
- Pages
- 461-467
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W1984729904
- Cited by
- 14
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2016: 1 · 2015: 2
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- intestinal hormones, jejunum, pancreas, insulin secretion, glucose stimulation, isolated perfused pancreas, pancreatic exocrine secretion, hyperosmolarity, hyperglycemia, canine
- MeSH terms
- Insulin Secretion, Animals, Blood Flow Velocity, Blood Glucose, Blood Pressure, Dogs, Gastrointestinal Hormones, Insulin, Jejunum, Oxygen Consumption, Pancreas, Perfusion
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
