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Botanical Drugs, Synergy, and Network Pharmacology: Forth and Back to Intelligent Mixtures

Gertsch, Jürg·2011·Planta Medica
DOI 10.1055/s-0030-1270904
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Research works printed but not linked: 160

  1. Hopkins AL. Network pharmacology. Nat Biotechnol 2007; 25: 1110- 1111
  2. Hopkins AL. Network pharmacology: the next paradigm in drug discov- ery. Nat Chem Biol 2008; 4: 682-690
  3. Altmann KH, Gertsch J. Anticancer drugs from nature-natural products as a unique source of new microtubule-stabilizing agents. Nat Prod Rep 2007; 24: 327-357
  4. Gertsch J, Meier S, Tschopp N, Altmann KH. New tubulin inhibitors from plants: A critical assessment. Chimia 2007; 61: 368-372
  5. Hansen O. Interaction of cardiac glycosides with (Na + + K + )-activated ATPase. A biochemical link to digitalis-induced inotropy. Pharmacol Rev 1984; 36: 143-163
  6. Prevatt-Smith KM, Prisinzano TE. New therapeutic potential for psycho- active natural products. Nat Prod Rep 2010; 27: 23-31
  7. Fozzard HA, Lipkind GM. The tetrodotoxin binding site is within the outer vestibule of the sodium channel. Mar Drugs 2010; 8: 219-234
  8. Nicolai EA. Rezepte und Kurarten mit theoretisch-praktischen Anmer- kungen, von D. Ernst Anton Nicolai, Hofrath und Professor zu Jena, Vol. 4. Jena: Cröker; 1788: 567
  9. Mann RD. From mithridatium to modern medicine: the management of drug safety. J R Soc Med 1988; 81: 725-728
  10. Catellani P, Console R. The rise and fall of mithridatium and theriac in pharmaceutical texts. Pharm Hist (Lond) 2007; 37: 2-9 12 Griffin JP. Venetian treacle and the foundation of medicines regulation. Br J Clin Pharmacol 2004; 58: 317-325
  11. Bosch F, Rosich L. The contributions of Paul Ehrlich to pharmacology: a tribute on the occasion of the centenary of his Nobel Prize. Pharmacol- ogy 2008; 82: 171-179
  12. Triggle DJ. Pharmacological receptors: a century of discovery -and more. Pharm Acta Helv 2000; 74: 79-84
  13. Crews CM. Targeting the undruggable proteome: the small molecules of my dreams. Chem Biol 2010; 17: 551-555
  14. Karczmar AG. The Otto Loewi Lecture. Loewiʼs discovery and the XXI century. Prog Brain Res 1996; 109: 1-27 17
  15. Hopkins AL, Mason JS, Overington JP. Can we rationally design promis- cuous drugs? Curr Opin Struct Biol 2006; 16: 127-136
  16. Hunt JT. Discovery of ixabepilone. Mol Cancer Ther. 2009; 8: 275-281
  17. Möhler H. The rise of a new GABA pharmacology. Neuropharmacology, advance online publication October 28, 2010; doi: 10.1016/j.neuro- pharm.2010.10.020 · DOI
  18. Sternbach LH. The benzodiazepine story. Prog Drug Res 1978; 22: 229- 266
  19. Andersson T, Weidolf L. Stereoselective disposition of proton pump in- hibitors. Clin Drug Investig 2008; 28: 263-279
  20. Lurje G, Lenz HJ. EGFR signaling and drug discovery. Oncology 2009; 77: 400-410
  21. Morrow JK, Tian L, Zhang S. Molecular networks in drug discovery. Crit Rev Biomed Eng 2010; 38: 143-156
  22. Chen B, Wild D, Guha R. PubChem as a source of polypharmacology. J Chem Inf Model 2009; 49: 2044-2055
  23. Yang X, Huang Y, Crowson M, Li J, Maitland ML, Lussier YA. Kinase inhi- bition-related adverse events predicted from in vitro kinome and clin- ical trial data. J Biomed Inform 2010; 43: 376-384
  24. Merino A, Bronowska AK, Jackson DB, Cahill DJ. Drug profiling: knowing where it hits. Drug Discov Today 2010; 15: 749-756
  25. Brötz-Oesterhelt H, Brunner NA. How many modes of action should an antibiotic have? Curr Opin Pharmacol 2009; 8: 564-573
  26. Kohanski MA, Dwyer DJ, Collins JJ. How antibiotics kill bacteria: from targets to networks. Nat Rev Microbiol 2010; 8: 423-435
  27. Wagner H. Synergy research: approaching a new generation of phyto- pharmaceuticals. Fitoterapia 2011; 82: 34-37
  28. Schmidt BM, Ribnicky DM, Lipsky PE, Raskin I. Revisiting the ancient concept of botanical therapeutics. Nat Chem Biol 2007; 3: 360-366
  29. Griffith FL. A medical papyrus from Egypt. Br Med J 1893; 1: 1172- 1174
  30. Goltz D. Mittelalterliche Pharmazie und Medizin: dargestellt an Ge- schichte und Inhalt des Antidotarium Nicolai: mit einem Nachdruck der Druckfassung von 1471. Stuttgart: Wissenschaftliche Verlagsge- sellschaft; 1976: 136
  31. Qiu J. Traditional medicine: a culture in the balance. Nature 2007; 448: 126-128
  32. Kong DX, Li XJ, Zhang HY. Where is the hope for drug discovery? Let his- tory tell the future. Drug Discov Today 2009; 14: 115-119
  33. Touwaide A, Pollio A, Aliotta G, Piomelli D, De Santo NG. Medicinal plants for the treatment of urogenital tract pathologies according to Dios- coridesʼ De Materia Medica. Am J Nephrol 1997; 17: 241-247
  34. Shapiro AK. The placebo effect in the history of medical treatment: im- plications for psychiatry. Am J Psychiatry 1959; 116: 298-304
  35. Patwardhan B, Vaidya DB, Chorghade M, Joshi SP. Reverse pharmacol- ogy and systems approaches for drug discovery and development. Curr Bioact Compd 2008; 4: 201-212
  36. Leonti M, Casu L, Sanna F, Bonsignore L. A comparison of medicinal plant use in Sardinia and Sicily-De Materia Medica revisited? J Ethno- pharmacol 2009; 121: 255-267
  37. Thomas E, Vanderbroek I, Goetghebeur P. The relationship between plant use and plant diversity in the Bolivian Andes, with special refer- ence to medicinal plant use. Hum Ecol 2008; 36: 861-879
  38. Moerman DE. Symbols and selectivity: a statistical analysis of native American medical ethnobotany. J Ethnopharmacol 1979; 1: 111-119
  39. Moerman DE. An analysis of the food plants and drug plants of native North America. J Ethnopharmacol 1996; 52: 1-22 44
  40. De Vos P. European materia medica in historical texts: longevity of a tradition and implications for future use. J Ethnopharmacol 2010; 132: 28-47 45
  41. Moerman DE, Jonas WB. Deconstructing the placebo effect and finding the meaning response. Ann Intern Med 2002; 136: 471-476
  42. Blanz M. [Placebos: aspects in medical history and approaches to defi- nition]. Fortschr Neurol Psychiatr 1991; 59: 361-370
  43. Howlett AC. Reverse pharmacology applied to the cannabinoid recep- tor. Trends Pharmacol Sci 1990; 11: 395-397
  44. Breinbauer R, Vetter IR, Waldmann H. From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries. Angew Chem Int Ed Engl 2002; 41: 2879-2890
  45. Cragg GM, Newman DJ, Snader KM. Natural products in drug discovery and development. J Nat Prod 1997; 60: 52-60
  46. La Clair JJ. Natural product mode of action (MOA) studies: a link be- tween natural and synthetic worlds. Nat Prod Rep 2010; 27: 969-995
  47. Thornburg CC, Zabriskie TM, McPhail KL. Deep-sea hydrothermal vents: potential hot spots for natural products discovery? J Nat Prod 2010; 73: 489-499
  48. Potterat O, Hamburger M. Drug discovery and development with plant- derived compounds. Prog Drug Res 2008; 65: 45-118 53
  49. Etkin NL. Perspectives in ethnopharmacology: forging a closer link be- tween bioscience and traditional empirical knowledge. J Ethnophar- macol 2001; 76: 177-182
  50. Adams M, Berset C, Kessler M, Hamburger M. Medicinal herbs for the treatment of rheumatic disorders-a survey of European herbals from the 16th and 17th century. J Ethnopharmacol 2009; 121: 343-359
  51. Verpoorte R, Crommelin D, Danhof M, Gilissen LJ, Schuitmaker H, van der Greef J, Witkamp RF. Commentary: "A systems view on the future of medicine: inspiration from Chinese medicine?". J Ethnopharmacol 2009; 121: 479-481
  52. Sagen AL, Gertsch J, Becker R, Heilmann J, Sticher O. Quinolizidine alka- loids from the curare adjuvant Clathrotropis glaucophylla. Phytochem- istry 2002; 61: 975-978
  53. Gratus C, Wilson S, Greenfield SM, Damery SL, Warmington SA, Grieve R, Steven NM, Routledge P. The use of herbal medicines by people with cancer: a qualitative study. BMC Complement Alternat Med 2009; 9: 14
  54. Neldner KH. Complementary and alternative medicine. Dermatol Clin 2000; 18: 189-193
  55. Graziose R, Lila MA, Raskin I. Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and func- tional foods. Curr Drug Discov Technol 2010; 7: 2-12
  56. Eng C. Are herbal medicines ripe for the cancer clinic? Sci Transl Med 2010; 2: 45ps41 63
  57. Lam W, Bussom S, Guan F, Jiang Z, Zhang W, Gullen EA, Liu SH, Cheng YC. The four-herb Chinese medicine PHY906 reduces chemotherapy-in- duced gastrointestinal toxicity. Sci Transl Med 2010; 2: 45-59 64
  58. Melzer J, Brignoli R, Diehm C, Reichling J, Do DD, Saller R. Treating inter- mittent claudication with Tibetan medicine Padma 28: does it work? Atherosclerosis 2006; 189: 39-46
  59. Melzer J, Schrader E, Brattström A, Schellenberg R, Saller R. Fixed herbal drug combination with and without butterbur (Ze 185) for the treat- ment of patients with somatoform disorders: randomized, placebo- controlled pharmaco-clinical trial. Phytother Res 2009; 23: 1303-1308
  60. Rodd R. Snuff synergy: preparation, use and pharmacology of yopo and Banisteriopsis caapi among the Piaroa of southern Venezuela. J Psycho- active Drugs 2002; 34: 273-279
  61. Gable RS. Risk assessment of ritual use of oral dimethyltryptamine (DMT) and harmala alkaloids. Addiction 2007; 102: 24-34
  62. Nahrstedt A, Butterweck V. Lessons learned from herbal medicinal products: the example of St. Johnʼs Wort (perpendicular). J Nat Prod 2010; 73: 1015-1021
  63. Ulrich-Merzenich G, Panek D, Zeitler H, Vetter H, Wagner H. Drug devel- opment from natural products: exploiting synergistic effects. Indian J Exp Biol 2010; 48: 208-219
  64. Liao ZG, Liang XL, Zhu JY, Zhao GW, Yang M, Wang GF, Jiang QY, Chen XL. Correlation between synergistic action of Radix Angelica dahurica ex- tracts on analgesic effects of Corydalis alkaloid and plasma concentra- tion of dl-THP. J Ethnopharmacol 2010; 129: 115-120
  65. Wagner H. Synergy research: a new approach to evaluating the efficacy of herbal mono-drug extracts and their combinations. Nat Prod Com- mun 2009; 4: 303-304
  66. Hellmann JK, Münter S, Wink M, Frischknecht F. Synergistic and additive effects of epigallocatechin gallate and digitonin on Plasmodium sporo- zoite survival and motility. PLoS One 2010; 5: e8682 74
  67. Wang L, Zhou GB, Liu P, Song JH, Liang Y, Yan XJ, Xu F, Wang BS, Mao JH, Shen ZX, Chen SJ, Chen Z. Dissection of mechanisms of Chinese medici- nal formula Realgar-Indigo naturalis as an effective treatment for pro- myelocytic leukemia. Proc Natl Acad Sci USA 2008; 105: 4826-4831
  68. Wang Y, Qin Q, Chen J, Kuang X, Xia J, Xie B, Wang F, Liang H, Qi Z. Syner- gistic effects of Isatis tinctoria L. and tacrolimus in the prevention of acute heart rejection in mice. Transpl Immunol 2009; 22: 5-11
  69. Lin FM, Chen LR, Lin EH, Ke FC, Chen HY, Tsai MJ, Hsiao PW. Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells. Carcinogenesis 2007; 28: 2521-2529
  70. Ginsburg I, Sadovnik M, Sallon S, Milo-Goldzweig I, Mechoulam R, Breuer A, Gibbs D, Varani J, Roberts S, Cleator E, Singh N. 47PADMA-28, a tradi- tional Tibetan herbal preparation inhibits the respiratory burst in hu- man neutrophils, the killing of epithelial cells by mixtures of oxidants and pro-inflammatory agonists and peroxidation of lipids. Inflammo- pharmacology 1999; 7: 47-62 79
  71. Chicca A, Raduner S, Pellati F, Strompen T, Altmann KH, Schoop R, Gertsch J. Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts. Int Immunopharmacol 2009; 9: 850-858
  72. HemaIswarya S, Doble M. Potential synergism of natural products in the treatment of cancer. Phytother Res 2006; 20: 239-249
  73. Gathirwa JW, Rukunga GM, Mwitari PG, Mwikwabe NM, Kimani CW, Muthaura CN, Kiboi DM, Nyangacha RM, Omar SA. Traditional herbal antimalarial therapy in Kilifi District, Kenya. J Ethnopharmacol 2011; 134: 434-442
  74. Fiebich BL, Knörle R, Appel K, Kammler T, Weiss G. Pharmacological stud- ies in an herbal drug combination of St. Johnʼs Wort (Hypericum perfo- ratum) and passion flower (Passiflora incarnata): In vitro and in vivo evidence of synergy between Hypericum and Passiflora in antidepres- sant pharmacological models. Fitoterapia 2011; 82: 474-480
  75. Adams LS, Seeram NP, Hardy ML, Carpenter C, Heber D. Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cell lines. Evid Based Complement Alternat Med 2006; 3: 117-124 84
  76. Berenbaum MC. What is synergy? Pharmacol Rev 1989; 41: 93-141
  77. Hastings I. How artemisinin-containing combination therapies slow the spread of antimalarial drug resistance. Trends Parasitol 2011; 27: 67-72
  78. Gatti A, Sabato E, Di Paolo AR, Mammucari M, Sabato AF. Oxycodone/ paracetamol: a low-dose synergic combination useful in different types of pain. Clin Drug Investig 2010; 30: 3-14 87
  79. MacPherson RD. The pharmacological basis of contemporary pain man- agement. Pharmacol Ther 2000; 88: 163-185
  80. Bansal T, Akhtar N, Jaggi M, Khar RK, Talegaonkar S. Novel formulation approaches for optimising delivery of anticancer drugs based on P-gly- coprotein modulation. Drug Discov Today 2009; 14: 1067-1074
  81. Bebrone C, Lassaux P, Vercheval L, Sohier JS, Jehaes A, Sauvage E, Galleni M. Current challenges in antimicrobial chemotherapy: focus on beta- lactamase inhibition. Drugs 2010; 70: 651-679
  82. Atal CK, Zutshi U, Rao PG. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. J Ethnopharmacol 1981; 4: 229-232
  83. Efferth T, Koch E. Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy. Curr Drug Targets 2011; 12: 122-132
  84. Wang SP, Liu L, Wang LL, Jiang P, Zhang JQ, Zhang WD, Liu RH. Screening and analysis of the multiple absorbed bioactive components and metab- olites in rat plasma after oral administration of Jitai tablets by high-per- formance liquid chromatography/diode-array detection coupled with electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 2010; 24: 1641-1652
  85. Atal CK, Dubey RK, Singh J. Biochemical basis of enhanced drug bio- availability by piperine: evidence that piperine is a potent inhibitor of drug metabolism. J Pharmacol Exp Ther 1985; 232: 258-262
  86. Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, Tharakan ST, Misra K, Priyadarsini IK, Rajasekharan KN, Aggarwal BB. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem Pharmacol 2008; 76: 1590-1611
  87. Hu G, Baker SP. Trends in unintentional injury deaths, U.S., 1999- 2005: age, gender, and racial/ethnic differences. Am J Prev Med 2009; 37: 188-194
  88. Colalto C. Herbal interactions on absorption of drugs: Mechanisms of action and clinical risk assessment. Pharmacol Res 2010; 62: 207-227
  89. Madabushi R, Frank B, Drewelow B, Derendorf H, Butterweck V. Hyper- forin in St. Johnʼs wort drug interactions. Eur J Clin Pharmacol 2006; 62: 225-233
  90. Zhou SF, Xue CC, Yu XQ, Wang G. Metabolic activation of herbal and di- etary constituents and its clinical and toxicological implications: an update. Curr Drug Metab 2007; 8: 526-553
  91. Zeng ZP, Jiang JG. Analysis of the adverse reactions induced by natural product-derived drugs. Br J Pharmacol 2010; 159: 1374-1391 100
  92. Roeder E, Wiedenfeld H. Pyrrolizidine alkaloids in medicinal plants of Mongolia, Nepal and Tibet. Pharmazie 2009; 64: 699-716 101
  93. Heinrich M, Chan J, Wanke S, Neinhuis C, Simmonds MS. Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2-a global assessment based on bibliographic sources. J Ethno- pharmacol 2009; 125: 108-144 102
  94. Berenbaum MC. Synergy assessment with growth curves. J Infect Dis 1984; 150: 304 103
  95. Berenbaum MC. Minor synergy and antagonism may be clinically im- portant. J Antimicrob Chemother 1987; 19: 271-273 104
  96. Leão PN, Pereira AR, Liu WT, Ng J, Pevzner PA, Dorrestein PC, König GM, Vasconcelos VM, Gerwick WH. Synergistic allelochemicals from a freshwater cyanobacterium. Proc Natl Acad Sci USA 2010; 107: 11 183-11 188 105
  97. Shiojiri K, Ozawa R, Kugimiya S, Uefune M, van Wijk M, Sabelis MW, Ta- kabayashi J. Herbivore-specific, density-dependent induction of plant volatiles: honest or "cry wolf" signals? PLoS One 2010; 5: e12161 106
  98. Kessler A, Baldwin IT. Defensive function of herbivore-induced plant volatile emissions in nature. Science 2001; 291: 2141-2144 107
  99. Gertsch J, Tobler RT, Brun R, Sticher O, Heilmann J. Antifungal, antipro- tozoal, cytotoxic and piscicidal properties of Justicidin B and a new ar- ylnaphthalide lignan from Phyllanthus piscatorum. Planta Med 2003; 69: 420-424 108
  100. Corning PA. The synergism hypothesis: on the concept of synergy and itʼs role in the evolution of complex systems. J Soc Evol Syst 1998; 21: 133-172 109
  101. McLean S, Duncan AJ. Pharmacological perspectives on the detoxifica- tion of plant secondary metabolites: implications for ingestive behav- ior of herbivores. J Chem Ecol 2006; 32: 1213-1228 110
  102. Yang CS, Lambert JD, Sang S. Antioxidative and anti-carcinogenic ac- tivities of tea polyphenols. Arch Toxicol 2009; 83: 11-21 111
  103. Zhang HY, Chen LL, Li XJ, Zhang J. Evolutionary inspirations for drug discovery. Trends Pharmacol Sci 2010; 31: 443-448 112
  104. Firn RD, Jones CG. A Darwinian view of metabolism: molecular proper- ties determine fitness. J Exp Bot 2009; 60: 719-726 113
  105. Firn RD, Jones CG. Natural products-a simple model to explain chem- ical diversity. Nat Prod Rep 2003; 20: 382-391 114
  106. Ewers RM, Thorpe S, Didham RK. Synergistic interactions between edge and area effects in a heavily fragmented landscape. Ecology 2007; 88: 96-106 115
  107. Schoenian I, Spiteller M, Ghaste M, Wirth R, Herz H, Spiteller D. Chemi- cal basis of the synergism and antagonism in microbial communities in the nests of leaf-cutting ants. Proc Natl Acad Sci USA, in press 116
  108. Hu Y, Platzer EG, Bellier A, Aroian RV. Discovery of a highly synergistic anthelmintic combination that shows mutual hypersusceptibility. Proc Natl Acad Sci USA 2010; 107: 5955-5960 117
  109. Firn RD, Jones CG. The evolution of secondary metabolism -a unifying model. Mol Microbiol 2000; 37: 989-994 118
  110. Cordell GA, Colvard MD. Some thoughts on the future of ethnopharma- cology. J Ethnopharmacol 2005; 100: 5-14 119
  111. de Sá Alves FR, Barreiro EJ, Fraga CA. From nature to drug discovery: the indole scaffold as a "privileged structure". Mini Rev Med Chem 2009; 9: 782-793 120
  112. Fischbach MA, Clardy J. One pathway, many products. Nat Chem Biol 2007; 3: 353-355 121
  113. Fischbach MA, Walsh CT, Clardy J. The evolution of gene collectives: How natural selection drives chemical innovation. Proc Natl Acad Sci USA 2008; 105: 4601-4608 122
  114. Moussaieff A, Mechoulam R. Boswellia resin: from religious ceremo- nies to medical uses; a review of in vitro, in vivo and clinical trials. J Pharm Pharmacol 2009; 61: 1281-1293 124
  115. Perry N, Perry E. Aromatherapy in the management of psychiatric dis- orders: clinical and neuropharmacological perspectives. CNS Drugs 2006; 20: 257-280 125
  116. Romics I, Siller G, Kohnen R, Mavrogenis S, Varga J, Holman E. A special terpene combination (Rowatinex ® ) improves stone clearance after ex- tracorporeal shockwave lithotripsy in urolithiasis patients: results of a placebo-controlled randomised controlled trial. Urol Int, in press 126
  117. Kohlert C, van Rensen I, März R, Schindler G, Graefe EU, Veit M. Bioavail- ability and pharmacokinetics of natural volatile terpenes in animals and humans. Planta Med 2000; 66: 495-505 127
  118. Buckle J. Use of aromatherapy as a complementary treatment for chronic pain. Alternat Ther Health Med 1999; 5: 42-51 128
  119. Wink M. Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective. Phytochemistry 2003; 64: 3-19 129
  120. McFrederick QS, Fuentes JD, Roulston T, Kathilankal JC, Lerdau M. Ef- fects of air pollution on biogenic volatiles and ecological interactions. Oecologia 2009; 160: 411-420 130
  121. Busch B, Hertweck C. Evolution of metabolic diversity in polyketide- derived pyrones: using the non-colinear aureothin assembly line as a model system. Phytochemistry 2009; 70: 1833-1840 131
  122. Bode HB, Bethe B, Höfs R, Zeeck A. Big effects from small changes: pos- sible ways to explore natureʼs chemical diversity. Chembiochem 2002; 3: 619-627 132
  123. Williamson EM. Synergy and other interactions in phytomedicines. Phytomedicine 2001; 8: 401-409 133
  124. Ulrich-Merzenich G, Panek D, Zeitler H, Wagner H, Vetter H. New per- spectives for synergy research with the "omic"-technologies. Phyto- medicine 2009; 16: 495-508 134
  125. Yeh P, Tschumi AI, Kishony R. Functional classification of drugs by prop- erties of their pairwise interactions. Nat Genet 2006; 38: 489-494 136
  126. Gertsch J, Viveros-Paredes JM, Taylor P. Plant immunostimulants-Sci- entific paradigm or myth? J Ethnopharmacol, advance online publica- tion July 8 2010; doi: 10.1016/j.jep.2010.06.044 137 · DOI
  127. Ríos JL, Recio MC, Escandell JM, Andújar I. Inhibition of transcription factors by plant-derived compounds and their implications in inflam- mation and cancer. Curr Pharm Des 2009; 15: 1212-1237 138
  128. Yeh P, Kishony R. Networks from drug-drug surfaces. Mol Syst Biol 2007; 3: 85 139
  129. Lehár J, Krueger AS, Avery W, Heilbut AM, Johansen LM, Price ER, Rickles RJ, Short 3rd GF, Staunton JE, Jin X, Lee MS, Zimmermann GR, Borisy AA. Synergistic drug combinations tend to improve therapeutically rele- vant selectivity. Nat Biotechnol 2009; 27: 659-666 141
  130. Rollinger JM, Schuster D, Danzl B, Schwaiger S, Markt P, Schmidtke M, Gertsch J, Raduner S, Wolber G, Langer T, Stuppner H. In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens. Planta Med 2009; 75: 195-204 142
  131. Leonti M, Cabras S, Weckerle CS, Solinas MN, Casu L. The causal depen- dence of present plant knowledge on herbals -contemporary medic- inal plant use in Campania (Italy) compared to Matthioli (1568). J Ethnopharmacol 2010; 130: 379-391 143
  132. Pollio A, De Natale A, Appetiti E, Aliotta G, Touwaide A. Continuity and change in the Mediterranean medical tradition: Ruta spp. (Rutaceae) in Hippocratic medicine and present practices. J Ethnopharmacol 2008; 116: 469-482 144
  133. Minker E, Bartha C, Rózsa Z, Szendrei K, Reisch J. Antispasmogenic ef- fect of rutamarin and arborinine on isolated smooth muscle organs. Planta Med 1979; 37: 156-160 145
  134. Golub TR. Mining the genome for combination therapies. Nat Med 2003; 9: 510-511 146
  135. Gao JL, He TC, Li YB, Wang YT. A traditional Chinese medicine formula- tion consisting of Rhizoma Corydalis and Rhizoma Curcumae exerts synergistic anti-tumor activity. Oncol Rep 2009; 22: 1077-1083 147
  136. Gertsch J. How scientific is the science in ethnopharmacology? Histor- ical perspectives and epistemological problems. J Ethnopharmacol 2009; 122: 177-183 148
  137. Woelkart K, Feizlmayr E, Dittrich P, Beubler E, Pinl F, Suter A, Bauer R. Pharmacokinetics of bilobalide, ginkgolide A and B after administra- tion of three different Ginkgo biloba L. preparations in humans. Phyto- ther Res 2010; 24: 445-450 149
  138. Woelkart K, Frye RF, Derendorf H, Bauer R, Butterweck V. Pharmacoki- netics and tissue distribution of dodeca-2E,4E,8E,10E/Z-tetraenoic ac- id isobutylamides after oral administration in rats. Planta Med 2009; 75: 1306-1313 150
  139. He SM, Li CG, Liu JP, Chan E, Duan W, Zhou SF. Disposition pathways and pharmacokinetics of herbal medicines in humans. Curr Med Chem 2010; 17: 4072-4113 151
  140. Feng C, Liu M, Shi X, Yang W, Kong D, Duan K, Wang Q. Pharmacokinetic properties of paeoniflorin, albiflorin and oxypaeoniflorin after oral gavage of extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba in rats. J Ethnopharmacol 2010; 130: 407-413 152
  141. Butterweck V, Liefländer-Wulf U, Winterhoff H, Nahrstedt A. Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats. Planta Med 2003; 69: 189-192 153
  142. Xu F, Liu Y, Dong H, Song R, Zhang Z. Pharmacokinetic comparison in rats of six bioactive compounds between Da-Cheng-Qi decoction and its parent herbal medicines. Nat Prod Commun 2010; 5: 795-800 154
  143. Wang X, Wang Z, Sun H, Lv H, Guan H, Meng X, Sun H, Zhang G, Cao H. Pharmacokinetics of cimifugin in rat plasma after oral administration of the extract of Saposhnikovia divaricatae root. Determination of ci- mifugin by high performance liquid chromatography coupled with solid phase extraction. Arzneimittelforschung 2008; 58: 445-450 156
  144. Lv H, Sun H, Sun W, Liu L, Wang P, Wang X, Cao H. Pharmacokinetic studies of a Chinese triple herbal drug formula. Phytomedicine 2008; 15: 993-1001 157
  145. Schmid B, Kötter I, Heide L. Pharmacokinetics of salicin after oral ad- ministration of a standardised willow bark extract. Eur J Clin Pharma- col 2001; 57: 387-391 158
  146. He SM, Li CG, Liu JP, Chan E, Duan W, Zhou SF. Disposition pathways and pharmacokinetics of herbal medicines in humans. Curr Med Chem, in press 159 López-Moreno CA. Poster O26 "Phytotherapy of malignant and benign tumors with mixtures of extracts of angiosperms from arid zones of North of Mexico". Naples: Natural Products in Cancer Therapy; 2008 160
  147. Schmidt B, Ribnicky DM, Poulev A, Logendra S, Cefalu WT, Raskin I. A natural history of botanical therapeutics. Metabolism 2008; 57: S3- S9 161
  148. Kneifel W, Czech E, Kopp B. Microbial contamination of medicinal plants-a review. Planta Med 2002; 68: 5-15 162
  149. Hamburger M. New approaches in analyzing the pharmacological properties of herbal extracts. Proc West Pharmacol Soc 2007; 50: 156-161 163
  150. Wolfender JL, Ndjoko K, Hostettmann K. Liquid chromatography with ultraviolet absorbance-mass spectrometric detection and with nu- clear magnetic resonance spectroscopy: a powerful combination for the on-line structural investigation of plant metabolites. J Chromatogr A 2003; 1000: 437-455 164
  151. Wang J, van der Heijden R, Spijksma G, Reijmers T, Wang M, Xu G, Han- kemeier T, van der Greef J. Alkaloid profiling of the Chinese herbal medicine Fuzi by combination of matrix-assisted laser desorption ionization mass spectrometry with liquid chromatography-mass spectrometry. J Chromatogr A 2009; 1216: 2169-2178 165
  152. Wang J, van der Heijden R, Spruit S, Hankermeier T, Chan K, van der Greef J, Xu G, Wang M. Quality and safety of Chinese herbal medicines guided by a systems biology perspective. J Ethnopharmacol 2009; 126: 31-41 166
  153. Yu WL, Guizzunti G, Foley TL, Burkart MD, La Clair JJ. An optimized im- munoaffinity fluorescent method for natural product target elucida- tion. J Nat Prod, in press 167
  154. Rosén J, Gottfries J, Muresan S, Backlund A, Oprea TI. Novel chemical space exploration via natural products. J Med Chem 2009; 52: 1953- 1962 168
  155. Jaki BU, Franzblau SG, Chadwick LR, Lankin DC, Zhang F, Wang Y, Pauli GF. Purity-activity relationships of natural products: the case of anti- TB active ursolic acid. J Nat Prod 2008; 71: 1742-1748 169
  156. Vornholt W, Hartmann M, Keusgen M. SPR studies of carbohydrate-lec- tin interactions as useful tool for screening on lectin sources. Biosens Bioelectron 2007; 22: 2983-2988 170
  157. Miyazaki I, Simizu S, Osada H. The application of the chemical array for biological study. Methods Mol Biol 2010; 669: 95-107 171
  158. van Breemen RB, Li Y. Caco-2 cell permeability assays to measure drug absorption. Expert Opin Drug Metab Toxicol 2005; 1: 175-185 172
  159. Bohlin L, Göransson U, Alsmark C, Wedén C, Backlund A. Natural prod- ucts in modern life science. Phytochem Rev 2010; 9: 279-301 173
  160. Larkins N, Wynn S. Pharmacognosy: phytomedicines and their mech- anisms. Vet Clin North Am Small Anim Pract 2004; 34: 291-327

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Metadata

Authors
Gertsch, J.
Venue
Planta Medica
Publisher
Georg Thieme Verlag KG
Published
2011-03-16
Volume
77
Issue
11
Pages
1086-1098
ISSN
  • 0032-0943
  • 1439-0221
DOI
10.1055/s-0030-1270904
Cited by
212
References
6
Language
en

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CoChat. (2026). Citation check: Botanical Drugs, Synergy, and Network Pharmacology: Forth and Back to Intelligent Mixtures. https://app.cochat.ai/papers/10.1055/s-0030-1270904
The paper
Gertsch, J. (2011). Botanical Drugs, Synergy, and Network Pharmacology: Forth and Back to Intelligent Mixtures. Planta Medica. https://doi.org/10.1055/s-0030-1270904

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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